Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats

  • Authors:
    • Jiahui Zheng
    • Shufeng Zhang
    • Tingting Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Preventive Medicine, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1587-1592
    |
    Published online on: December 21, 2018
       https://doi.org/10.3892/etm.2018.7123
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Expression changes of Notch-1 and nuclear factor-κB (NF-κB) in cardiomyocytes from coronary heart disease (CHD) rats were investigated. The CHD model established by high-fat diet in 48 clean SD rats was set as the observation group, and another 48 healthy rats routinely fed were the control group. Rats were sacrificed on the 1st, 3rd, 7th, and 14th days after successful modeling. The rat myocardial cells were harvested to examine the changes of Notch-1 and NF-κB using immunoblot (western blot analysis) and TUNEL assay. Cardiomyocyte apoptotic rate, by Pearson's correlation test was used to analyze the correlation between Notch-1 and NF-κB. With the prolongation of the course of CHD in rats, the expression levels of Notch-1 and NF-κB proteins gradually increased, and the expression in the observation group was significantly higher than that in the control group (P<0.01). On the seventh day, the expression levels of Notch-1 and NF-κB protein in the rats in the observation group showed significant difference from those on day 1 and day 3 (P<0.05), and they were significantly different on the 7th and 14th days (P<0.05). There was no correlation between the expression level of the two proteins with the age and sex of the rats. Pearson's correlation analysis showed that Notch-1 was positively correlated with NF-κB protein (r=0.745, P=0.005). The results of myocardial apoptosis test showed that with the prolongation of the CHD course in the rats of the observation group, the cardiomyocyte apoptosis rate did not differ from the control group. The expression of Notch-1 and NF-κB protein is increased in cardiomyocytes of CHD rats. Notch-1 and NF-κB participate in the occurrence and development of CHD.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Dawber TR, Moore FE and Mann GV: II. Coronary heart disease in the Framingham study. Int J Epidemiol. 44:1767–1780. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, et al: American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics - 2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 119:480–486. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Xie W, Li G, Zhao D, Xie X, Wei Z, Wang W, Wang M, Li G, Liu W, Sun J, et al: Relationship between fine particulate air pollution and ischaemic heart disease morbidity and mortality. Heart. 101:257–263. 2015. View Article : Google Scholar : PubMed/NCBI

4 

McClelland RL, Jorgensen NW, Budoff M, Blaha MJ, Post WS, Kronmal RA, Bild DE, Shea S, Liu K, Watson KE, et al: 10-year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors: Derivation in the MESA (Multi-Ethnic Study of Atherosclerosis) with validation in the HNR (Heinz Nixdorf Recall) study and the DHS (Dallas Heart Study). J Am Coll Cardiol. 66:1643–1653. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Patel TP, Rawal K, Bagchi AK, Akolkar G, Bernardes N, Dias DS, Gupta S and Singal PK: Insulin resistance: An additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes. Heart Fail Rev. 21:11–23. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhou QZ, Zhang G, Long HB, Lei F, Ye F, Jia XF, Zhou YL, Kang JP and Feng DX: Effect of spinal cord extracts after spinal cord injury on proliferation of rat embryonic neural stem cells and Notch signal pathway in vitro. Asian Pac J Trop Med. 7:562–567. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kozmann G, Jókuthy A, Virányi V and Vassányi I: Methodological studies related to cardiovascular risk assessment. Stud Health Technol Inform. 90:635–638. 2002.PubMed/NCBI

8 

Jin Y, Liu K, Peng J, Wang C, Kang L, Chang N and Sun H: Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway. Toxicol Lett. 232:149–158. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Hamid T, Guo SZ, Kingery JR, Xiang X, Dawn B and Prabhu SD: Cardiomyocyte NF-kappaB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure. Cardiovasc Res. 89:129–138. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Mnafgui K, Hajji R, Derbali F, Gammoudi A, Khabbabi G, Ellefi H, Allouche N, Kadri A and Gharsallah N: Anti-inflammatory, antithrombotic and cardiac remodeling preventive effects of eugenol in isoproterenol-induced myocardial infarction in wistar rat. Cardiovasc Toxicol. 16:336–344. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Yin G, Wang Y, Cen XM, Yang M, Liang Y and Xie QB: Lipid peroxidation-mediated inflammation promotes cell apoptosis through activation of NF-κB pathway in rheumatoid arthritis synovial cells. Mediators Inflamm. 2015:4603102015. View Article : Google Scholar : PubMed/NCBI

12 

Fender AW, Nutter JM, Fitzgerald TL, Bertrand FE and Sigounas G: Notch-1 promotes stemness and epithelial to mesenchymal transition in colorectal cancer. J Cell Biochem. 116:2517–2527. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Satija A, Bhupathiraju SN, Spiegelman D, Chiuve SE, Manson JE, Willett W, Rexrode KM, Rimm EB and Hu FB: Healthful and unhealthful plant-based diets and the risk of coronary heart disease in U.S. adults. J Am Coll Cardiol. 70:411–422. 2017. View Article : Google Scholar : PubMed/NCBI

14 

De Bruyne B, Fearon WF, Pijls NH, Barbato E, Tonino P, Piroth Z, Jagic N, Mobius-Winckler S, Rioufol G, Witt N, et al: FAME 2 Trial Investigators: Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med. 371:1208–1217. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Hu SS, Kong LZ, Gao RL, Zhu ML, Wang W, Wang YJ, Wu ZS, Chen WW and Liu MB: Editorial Board: Outline of the report on cardiovascular disease in China, 2010. Biomed Environ Sci. 25:251–256. 2012.PubMed/NCBI

16 

Hansson GK, Libby P and Tabas I: Inflammation and plaque vulnerability. J Intern Med. 278:483–493. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, et al: Flow perturbation mediates neutrophil recruitment and potentiates endothelial injury via TLR2 in mice: Implications for superficial erosion. Circ Res. 121:31–42. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Braune EB and Lendahl U: Notch - a goldilocks signaling pathway in disease and cancer therapy. Discov Med. 21:189–196. 2016.PubMed/NCBI

19 

Gu JW, Rizzo P, Pannuti A, Golde T, Osborne B and Miele L: Notch signals in the endothelium and cancer ‘stem-like’ cells: Opportunities for cancer therapy. Vasc Cell. 4:72012. View Article : Google Scholar : PubMed/NCBI

20 

Ray A, Vasudevan S and Sengupta S: 6-Shogaol inhibits breast cancer cells and stem cell-like spheroids by modulation of Notch signaling pathway and induction of autophagic cell death. PLoS One. 10:e01376142015. View Article : Google Scholar : PubMed/NCBI

21 

Wilson A, MacDonald HR and Radtke F: Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med. 194:1003–1012. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, et al: NEMO prevents RIP kinase 1-mediated epithelial cell death and chronic intestinal inflammation by NF-κB-dependent and -independent functions. Immunity. 44:553–567. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Twait E, Williard DE and Samuel I: Dominant negative p38 mitogen-activated protein kinase expression inhibits NF-kappaB activation in AR42J cells. Pancreatology. 10:119–128. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Jin JL, Deng ZT, Lyu RG, Liu XH and Wei JR: Expression changes of Notch and nuclear factor-κB signaling pathways in the rat heart with myocardial infarction. Zhonghua Xin Xue Guan Bing Za Zhi. 45:507–512. 2017.(In Chinese). PubMed/NCBI

25 

Li L, Zhao F, Lu J, Li T, Yang H, Wu C and Liu Y: Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation. PLoS One. 9:e959122014. View Article : Google Scholar : PubMed/NCBI

26 

Yu B and Song B: Notch 1 signalling inhibits cardiomyocyte apoptosis in ischaemic postconditioning. Heart Lung Circ. 23:152–158. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng J, Zhang S and Wang T: Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats. Exp Ther Med 17: 1587-1592, 2019.
APA
Zheng, J., Zhang, S., & Wang, T. (2019). Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats. Experimental and Therapeutic Medicine, 17, 1587-1592. https://doi.org/10.3892/etm.2018.7123
MLA
Zheng, J., Zhang, S., Wang, T."Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats". Experimental and Therapeutic Medicine 17.3 (2019): 1587-1592.
Chicago
Zheng, J., Zhang, S., Wang, T."Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1587-1592. https://doi.org/10.3892/etm.2018.7123
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng J, Zhang S and Wang T: Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats. Exp Ther Med 17: 1587-1592, 2019.
APA
Zheng, J., Zhang, S., & Wang, T. (2019). Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats. Experimental and Therapeutic Medicine, 17, 1587-1592. https://doi.org/10.3892/etm.2018.7123
MLA
Zheng, J., Zhang, S., Wang, T."Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats". Experimental and Therapeutic Medicine 17.3 (2019): 1587-1592.
Chicago
Zheng, J., Zhang, S., Wang, T."Expression of Notch-1 and nuclear factor-κB signal pathway in myocardial cells of coronary heart disease rats". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1587-1592. https://doi.org/10.3892/etm.2018.7123
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team