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Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes

  • Authors:
    • Yu Zhu
    • Yongfang Huang
    • Mingmin Liu
    • Qi Yan
    • Wanhong Zhao
    • Ping Yang
    • Qin Gao
    • Juanjuan Wei
    • Wenxia Zhao
    • Lishan Ma
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Jiangwan Hospital, Shanghai 200434, P.R. China, Department of Obstetrics and Gynecology, Yangpu Hospital Affiliated to Tongji University, Shanghai 200090, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1742-1748
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    Published online on: December 24, 2018
       https://doi.org/10.3892/etm.2018.7131
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Abstract

The aim of the present study was to investigate the inhibitory effects of the polyphenol epigallocatechin‑3‑gallate (EGCG) on the growth of cervical carcinoma cell lines infected with different high‑risk human papillomavirus (HPV) subtypes, as well as the associated regulation of microRNA (miR) expression. Cell proliferation was measured using an MTT assay. The effects of 7 different concentrations of EGCG (100, 80, 60, 40, 20, 10 and 0 µg/ml) on HeLa cell proliferation were assessed. HeLa cell growth was significantly inhibited by EGCG in a dose‑ and time‑dependent manner (P<0.05), and the IC50 was 90.74 and 72.74 µg/ml at 24 and 48 h, respectively. The expression of miR‑210, miR‑29a, miR‑203 and miR‑125b in HeLa (HPV16/18+), SiHa (HPV16+), CaSki (HPV16+) and C33A (HPV‑) cell lines was measured using quantitative polymerase chain reaction analysis. In CA33 cells, miR‑203 (all P<0.001) and miR‑125b (P<0.01 and <0.0001) were significantly downregulated by EGCG, and miR‑210 was significantly upregulated with 40 and 60 µg/ml EGCG (P<0.0001). miR‑125b was significantly downregulated (P<0.001 and <0.0001), and miR‑210 and miR‑29 were significantly upregulated by ≤80 µg/ml EGCG in HeLa cells (all P<0.0001). In CaSki cells, miR‑210, miR‑29a (all P<0.001) and miR‑125b (P<0.01‑0.0001) were significantly upregulated by EGCG. In SiHa cells, miR‑125b (both P<0.001) and miR‑203 (P<0.01 and <0.0001) were significantly upregulated by EGCG. In conclusion, the results of the present study suggest that EGCG suppresses cervical carcinoma cell growth, possibly via regulating the expression of miRs, suggesting their potential as therapeutic targets for the control and prevention of cervical cancer. Additionally, EGCG may be considered a novel anti‑cervical cancer drug in the future.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Jiang X, Tang H and Chen T: Epidemiology of gynecologic cancers in China. J Gynecol Oncol. 29:e72018. View Article : Google Scholar : PubMed/NCBI

4 

Wang H, Cheng X, Ye J, Xu X, Hong Y, Sui L, You Z and Xie X: Distribution of human papilloma virus genotype prevalence in invasive cervical carcinomas and precancerous lesions in the Yangtze River Delta area, China. BMC Cancer. 18:4872018. View Article : Google Scholar : PubMed/NCBI

5 

de Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, Tous S, Felix A, Bravo LE, Shin HR, et al: Human papillomavirus genotype attribution in invasive cervical cancer: A retrospective cross-sectional worldwide study. Lancet Oncol. 11:1048–1056. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Depuydt CE, Beert J, Bosmans E and Salembier G: Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin. Facts Views Vis Obgyn. 8:211–222. 2016.PubMed/NCBI

7 

Jiang E, Sun X, Kang H, Sun L, An W, Yao Y and Hu X: Dehydrocostus lactone inhibits proliferation, antiapoptosis, and invasion of cervical cancer cells through PI3K/Akt signaling pathway. Int J Gynecol Cancer. 25:1179–1186. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Ambros V: The functions of animal micrornas. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Romano G, Veneziano D, Acunzo M and Croce CM: Small non-coding RNA and cancer. Carcinogenesis. 38:485–491. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Lorenzi L, Avila Cobos F, Decock A, Everaert C, Helsmoortel H, Lefever S, Verboom K, Volders PJ, Speleman F, Vandesompele J and Mestdagh P: Long non-coding RNA expression profiling in cancer: Challenges and opportunities. Genes Chromosomes Cancer. 2018 Nov 21;Doi: 10.1002/gcc.22709. (Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

12 

Di Leva G, Garofalo M and Croce CM: MicroRNAs in cancer. Annu Rev Pathol. 9:287–314. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Soto D, Song C and McLaughlin-Drubin ME: Epigenetic alterations in human papillomavirus-associated cancers. Viruses. 9:E2482017. View Article : Google Scholar : PubMed/NCBI

14 

Eskander RN: The epigenetic landscape in the treatment of gynecologic malignancies. Am Soc Clin Oncol Educ Book. 480–487. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Pardini B, De Maria D, Francavilla A, Di Gaetano C, Ronco G and Naccarati A: MicroRNAs as markers of progression in cervical cancer: A systematic review. BMC Cancer. 18:6962018. View Article : Google Scholar : PubMed/NCBI

16 

Laengsri V, Kerdpin U, Plabplueng C, Treeratanapiboon L and Nuchnoi P: Cervical cancer markers: Epigenetics and microRNAs. Lab Med. 49:97–111. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Wang F, Li B and Xie X: The roles and clinical significance of microRNAs in cervical cancer. Histol Histopathol. 31:131–139. 2016.PubMed/NCBI

18 

Granados-López AJ, Ruiz-Carrillo JL, Servín-González LS, Martínez-Rodríguez JL, Reyes-Estrada CA, Gutiérrez-Hernández R and López JA: Use of mature miRNA strand selection in miRNAs families in cervical cancer development. Int J Mol Sci. 18:E4072017. View Article : Google Scholar : PubMed/NCBI

19 

Cui F, Li X, Zhu X, Huang L, Huang Y, Mao C, Yan Q, Zhu J, Zhao W and Shi H: MiR-125b inhibits tumor growth and promotes apoptosis of cervical cancer cells by targeting phosphoinositide 3-kinase catalytic subunit delta. Cell Physiol Biochem. 30:1310–1318. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhu X, Er K, Mao C, Yan Q, Xu H, Zhang Y, Zhu J, Cui F, Zhao W and Shi H: miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem. 32:64–73. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Granados López AJ and López JA: Multistep model of cervical cancer: Participation of miRNAs and coding genes. Int J Mol Sci. 15:15700–15733. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Wang YQ, Lu JL, Liang YR and Li QS: Suppressive effects of EGCG on cervical cancer. Molecules. 23:E23342018. View Article : Google Scholar : PubMed/NCBI

23 

Hou IC, Amarnani S, Chong MT and Bishayee A: Green tea and the risk of gastric cancer: Epidemiological evidence. World J Gastroenterol. 19:3713–3722. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Johnson R, Bryant S and Huntley AL: Green tea and green tea catechin extracts: An overview of the clinical evidence. Maturitas. 73:280–287. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Danese E, Minicozzi AM, Benati M, Paviati E, Lima-Oliveira G, Gusella M, Pasini F, Salvagno GL, Montagnana M and Lippi G: Reference miRNAs for colorectal cancer: Analysis and verification of current data. Sci Rep. 7:84132017. View Article : Google Scholar : PubMed/NCBI

27 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A and Bray F: Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2018 Oct 23;Doi: 10.1002/ijc.31937. View Article : Google Scholar

29 

Quan Y and Yi Q: Across China: HPV vaccine becomes available for women under 45 in Shanghai. xinhuanet. 03–Aug;2018.http://www.xinhuanet.com/english/2018-03/08/c_137025464.htm

30 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Yang L, Zhu Y, Bai Y, Zhang X and Ren C: The clinical application of HPV E6/E7 mRNA testing in triaging women with atypical squamous cells of undetermined significance or low-grade squamous intra-epithelial lesion Pap smear: A meta-analysis. J Cancer Res Ther. 13:613–620. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Terenzi F, Saikia P and Sen GC: Interferon-inducible protein P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J. 27:3311–3321. 2015. View Article : Google Scholar

33 

Shirakami Y and Shimizu M: Possible mechanisms of green tea and its constituents against cancer. Molecules. 23:E22842018. View Article : Google Scholar : PubMed/NCBI

34 

Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G and Corti A: Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study. Cancer Res. 66:1234–1240. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A and Wnuk M: Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. Apoptosis. 22:800–815. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Wu L, Liu T, Xiao Y, Li X, Zhu Y, Zhao Y, Bao J and Wu C: Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells. Int J Biol Macromol. 85:217–226. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Kumar VB, Yuan TC, Liou JW, Yang CJ, Sung PJ and Weng CF: Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles. Mutat Res. 707:42–52. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Zhou DH, Wang X and Feng Q: EGCG enhances the efficacy of cisplatin by downregulating hsa-miR-98-5p in NSCLC A549 cells. Nutr Cancer. 66:636–644. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Lorincz AT: Virtues and weaknesses of DNA methylation as a test for cervical cancer prevention. Acta Cytol. 60:501–512. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Srivastava SK, Ahmad A, Zubair H, Miree O, Singh S, Rocconi RP, Scalici J and Singh AP: MicroRNAs in gynecological cancers: Small molecules with big implications. Cancer Lett. 407:123–138. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Singh BN, Shankar S and Srivastava PK: Green tea catechin, epigallocat-echin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications. Biochem Pharmacol. 82:1807–1821. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Wang F, Chang Z, Fan Q and Wang L: Epigallocatechin 3 gallate inhibitsthe proliferation and migration of human ovarian carcinoma cells by modulating p38 kinase and matrix metalloproteinase-2. Mol Med Rep. 9:1085–1089. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Zhang D, Al-Hendy M, Richard-Davis G, Montgomery-Rice V, Rajaratnam V and Al-Hendy A: Anti proliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells. Fertil Steril. 94:1887–1893. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Al-Hazzani AA and Alshatwi AA: Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells. Food Chem Toxicol. 49:3281–3286. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Hara-Terawaki A, Takagaki A, Kobayashi H and Nanjo F: Inhibitory activity of catechin metabolites produced by intestinal microbiota on proliferation of HeLa cells. Biol Pharm Bull. 40:1331–1335. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yuen ST, Chan TL, Kwong DL, Au GK, et al: MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA. 299:425–436. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Iorio MV, Visone R, Di Leva G, Donati V, Petrocca F, Casalini P, Taccioli C, Volinia S, Liu CG, Alder H, et al: MicroRNA signatures in human ovarian cancer. Cancer Res. 67:8699–8707. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S and Zucman-Rossi J: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology. 47:1955–1963. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Gaur A, Jewell DA, Liang Y, Ridzon D, Moore JH, Chen C, Ambros VR and Israel MA: Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res. 67:2456–2468. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Craig VJ, Cogliatti SB, Rehrauer H, Wündisch T and Müller A: Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesis. Cancer Res. 71:3616–3624. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Banzhaf-Strathmann J and Edbauer D: Good guy or bad guy: The opposing roles of microRNA 125b in cancer. Cell Commun Signal. 12:302014. View Article : Google Scholar : PubMed/NCBI

52 

Jiménez-Wences H, Peralta-Zaragoza O and Fernández-Tilapa G: Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep. 31:2467–2476. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Hu G, Zhao X, Wang J, Lv L, Wang C, Feng L, Shen L and Ren W: miR-125b regulates the drug-resistance of breast cancer cells to doxorubicin by targeting HAX-1. Oncol Lett. 15:1621–1629. 2018.PubMed/NCBI

54 

Yang D, Zhan M, Chen T, Chen W, Zhang Y, Xu S, Yan J, Huang Q and Wang J: miR-125b-5p enhances chemotherapy sensitivity to cisplatin by down-regulating Bcl-2 in gallbladder cancer. Sci Rep. 7:431092017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Huang Y, Liu M, Yan Q, Zhao W, Yang P, Gao Q, Wei J, Zhao W, Ma L, Ma L, et al: Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes. Exp Ther Med 17: 1742-1748, 2019.
APA
Zhu, Y., Huang, Y., Liu, M., Yan, Q., Zhao, W., Yang, P. ... Ma, L. (2019). Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes. Experimental and Therapeutic Medicine, 17, 1742-1748. https://doi.org/10.3892/etm.2018.7131
MLA
Zhu, Y., Huang, Y., Liu, M., Yan, Q., Zhao, W., Yang, P., Gao, Q., Wei, J., Zhao, W., Ma, L."Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes". Experimental and Therapeutic Medicine 17.3 (2019): 1742-1748.
Chicago
Zhu, Y., Huang, Y., Liu, M., Yan, Q., Zhao, W., Yang, P., Gao, Q., Wei, J., Zhao, W., Ma, L."Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1742-1748. https://doi.org/10.3892/etm.2018.7131
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Huang Y, Liu M, Yan Q, Zhao W, Yang P, Gao Q, Wei J, Zhao W, Ma L, Ma L, et al: Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes. Exp Ther Med 17: 1742-1748, 2019.
APA
Zhu, Y., Huang, Y., Liu, M., Yan, Q., Zhao, W., Yang, P. ... Ma, L. (2019). Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes. Experimental and Therapeutic Medicine, 17, 1742-1748. https://doi.org/10.3892/etm.2018.7131
MLA
Zhu, Y., Huang, Y., Liu, M., Yan, Q., Zhao, W., Yang, P., Gao, Q., Wei, J., Zhao, W., Ma, L."Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes". Experimental and Therapeutic Medicine 17.3 (2019): 1742-1748.
Chicago
Zhu, Y., Huang, Y., Liu, M., Yan, Q., Zhao, W., Yang, P., Gao, Q., Wei, J., Zhao, W., Ma, L."Epigallocatechin gallate inhibits cell growth and regulates miRNA expression in cervical carcinoma cell lines infected with different high‑risk human papillomavirus subtypes". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1742-1748. https://doi.org/10.3892/etm.2018.7131
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