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microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1

  • Authors:
    • Junan Hu
    • Wei Shen
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Beilun District People's Hospital of Ningbo City, Ningbo, Zhejiang 315800, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1579-1586
    |
    Published online on: January 4, 2019
       https://doi.org/10.3892/etm.2019.7152
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Abstract

Dysfunction of the microRNA (miR) network has been indicated as a major regulator in neurological diseases. However, there is limited understanding regarding the functional significance of miRs in ischemic brain injury. In the present study, miR‑196a expression was significantly increased in rat brains and neurons following transient middle cerebral artery occlusion (MCAO) or oxygen‑glucose deprivation, respectively. In addition, repression of miR‑196a significantly decreased neuron cell apoptosis and the infarct size in rats subjected to MCAO (P<0.05). Furthermore, miR‑196a was indicated to directly target and inhibit high mobility group A1 expression, which indicated a potential role for miR‑196a in ischemic brain injury. These findings suggested that miR‑196a may be involved in regulating neuronal cell death, thus offering a novel target for the development of therapeutic agents against ischemic brain injury.
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Copy and paste a formatted citation
Spandidos Publications style
Hu J and Shen W: microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1. Exp Ther Med 17: 1579-1586, 2019.
APA
Hu, J., & Shen, W. (2019). microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1. Experimental and Therapeutic Medicine, 17, 1579-1586. https://doi.org/10.3892/etm.2019.7152
MLA
Hu, J., Shen, W."microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1". Experimental and Therapeutic Medicine 17.3 (2019): 1579-1586.
Chicago
Hu, J., Shen, W."microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1579-1586. https://doi.org/10.3892/etm.2019.7152
Copy and paste a formatted citation
x
Spandidos Publications style
Hu J and Shen W: microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1. Exp Ther Med 17: 1579-1586, 2019.
APA
Hu, J., & Shen, W. (2019). microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1. Experimental and Therapeutic Medicine, 17, 1579-1586. https://doi.org/10.3892/etm.2019.7152
MLA
Hu, J., Shen, W."microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1". Experimental and Therapeutic Medicine 17.3 (2019): 1579-1586.
Chicago
Hu, J., Shen, W."microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1". Experimental and Therapeutic Medicine 17, no. 3 (2019): 1579-1586. https://doi.org/10.3892/etm.2019.7152
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