microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1

Hu,Junan; Shen,Wei

doi:10.3892/etm.2019.7152

microRNA‑196a attenuates ischemic brain injury in rats by directly targeting high mobility group A1

Authors:
- Junan Hu
- Wei Shen
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Affiliations: Department of Neurosurgery, Beilun District People's Hospital of Ningbo City, Ningbo, Zhejiang 315800, P.R. China
Published online on: January 4, 2019 https://doi.org/10.3892/etm.2019.7152
Pages: 1579-1586
Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dysfunction of the microRNA (miR) network has been indicated as a major regulator in neurological diseases. However, there is limited understanding regarding the functional significance of miRs in ischemic brain injury. In the present study, miR‑196a expression was significantly increased in rat brains and neurons following transient middle cerebral artery occlusion (MCAO) or oxygen‑glucose deprivation, respectively. In addition, repression of miR‑196a significantly decreased neuron cell apoptosis and the infarct size in rats subjected to MCAO (P<0.05). Furthermore, miR‑196a was indicated to directly target and inhibit high mobility group A1 expression, which indicated a potential role for miR‑196a in ischemic brain injury. These findings suggested that miR‑196a may be involved in regulating neuronal cell death, thus offering a novel target for the development of therapeutic agents against ischemic brain injury.

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