Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice

  • Authors:
    • Wendong Sun
    • Zhiguo Wang
    • Quanchen Xu
    • Huibin Sun
    • Xiaoxuan Liu
    • Jianjun Yang
    • Rundan Hong
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, College of Stomatology, Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Burn and Plastic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2199-2205
    |
    Published online on: January 11, 2019
       https://doi.org/10.3892/etm.2019.7165
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cell‑based tissue engineering is a promising alternative for periodontal regeneration as current therapies fail to reconstitute tissue damage caused by periodontitis. As newly identified postnatal stem cells, gingiva‑derived mesenchymal stem cells (GMSCs) have been focused on for isolation and expansion in vitro of cells with multi‑­differentiation potential and immunomodulatory capacities. It has been demonstrated that systemically delivered GMSCs can home to the mandibular bone defect sites and promote bone regeneration. However, the role of transplanted GMSCs in the treatment of periodontitis has not been reported. In the present study, GMSCs were transplanted into C57BL/6J mice with periodontitis via the tail vein to investigate the contribution of GMSCs to periodontal tissue regeneration. Results demonstrated that the alveolar bone heights of mice with transplanted GMSCs were significantly increased compared with the control groups and GMSCs were detected in newly formed periodontal ligament and alveolar bone. The results of the present study implied that systemically transplanted GMSCs could home to periodontal injury sites and promote periodontal tissue regeneration.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ and Marcenes W: Global burden of severe periodontitis in 1990–2010: A systematic review and meta-regression. J Dent Res. 93:1045–1053. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Hynes K, Menicanin D, Gronthos S and Bartold PM: Clinical utility of stem cells for periodontal regeneration. Periodontology. 59:203–227. 2012. View Article : Google Scholar

3 

Salvi GE, Mischler DC, Schmidlin K, Matuliene G, Pjetursson BE, Brägger U and Lang NP: Risk factors associated with the longevity of multi-rooted teeth. Long-term outcomes after active and supportive periodontal therapy. J Clin Periodontol. 41:701–707. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Silvério KG, Benatti BB, Casati MZ, Sallum EA and Nociti FH Jr: Stem cells: Potential therapeutics for periodontal regeneration. Stem Cell Rev. 4:13–19. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Luria EA, Panasyuk AF and Friedenstein AY: Fibroblast colony formation from monolayer cultures of blood cells. Transfusion. 11:345–349. 1971. View Article : Google Scholar : PubMed/NCBI

6 

Du J, Shan Z, Ma P, Wang S and Fan Z: Allogeneic bone marrow mesenchymal stem cell transplantation for periodontal regeneration. J Dent Res. 93:183–188. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY and Shi S: Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 364:149–155. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Huang TJ, Sonoyama W, Chen J and Sang HP: In vitro characterization of human dental pulp cells: Various isolation methods and culturing environments. Cell Tissue Res. 324:225–236. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Möhl C, Sippel C and Hoffmann KH: Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 24:155–165. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Tomar GB, Srivastava RK, Gupta N, Barhanpurkar AP, Pote ST, Jhaveri HM, Mishra GC and Wani MR: Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine. Biochem Biophys Res Commun. 393:377–383. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S and Le AD: Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol. 183:7787–7798. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Su WR, Zhang QZ, Shi SH, Nguyen AL and Le AD: Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms. Stem Cells. 29:1849–1860. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Wada N, Wang B, Lin NH, Laslett AL, Gronthos S and Bartold PM: Induced pluripotent stem cell lines derived from human gingival fibroblasts and periodontal ligament fibroblasts. J Periodontal Res. 46:438–447. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Xu QC, Wang ZG, Ji QX, Yu XB, Xu XY, Yuan CQ, Deng J and Yang PS: Systemically transplanted human gingiva-derived mesenchymal stem cells contributing to bone tissue regeneration. Int J Clin Exp Pathol. 7:4922–4929. 2014.PubMed/NCBI

15 

Häkkinen L, Uitto VJ and Larjava H: Cell biology of gingival wound healing. Periodontology. 24:127–152. 2000. View Article : Google Scholar

16 

Ge S, Mrozik KM, Menicanin D, Gronthos S and Bartold PM: Isolation and characterization of mesenchymal stem cell-like cells from healthy and inflamed gingival tissue: Potential use for clinical therapy. Regen Med. 7:819–832. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Tang L, Li N, Xie H and Jin Y: Characterization of mesenchymal stem cells from human normal and hyperplastic gingiva. J Cell Physiol. 226:832–842. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj and Horwitz E: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 8:315–317. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Ye Z, Yu X and Cheng L: Lentiviral gene transduction of mouse and human stem cells. Methods Mol Biol. 430:243–253. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Abe T and Hajishengallis G: Optimization of the ligature-induced periodontitis model in mice. J Immunol Methods. 394:49–54. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Liechty KW, Mackenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR and Flake AW: Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med. 6:1282–1286. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Guo X, Bai Y, Zhang L, Zhang B, Zagidullin N, Carvalho K, Du Z and Cai B: Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: New regulators and its implications. Stem Cell Res Ther. 9:442018. View Article : Google Scholar : PubMed/NCBI

23 

Aggarwal S and Pittenger MF: Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 105:1815–1822. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R and Shi S: Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res. 84:907–912. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun W, Wang Z, Xu Q, Sun H, Liu X, Yang J and Hong R: The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice. Exp Ther Med 17: 2199-2205, 2019.
APA
Sun, W., Wang, Z., Xu, Q., Sun, H., Liu, X., Yang, J., & Hong, R. (2019). The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice. Experimental and Therapeutic Medicine, 17, 2199-2205. https://doi.org/10.3892/etm.2019.7165
MLA
Sun, W., Wang, Z., Xu, Q., Sun, H., Liu, X., Yang, J., Hong, R."The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice". Experimental and Therapeutic Medicine 17.3 (2019): 2199-2205.
Chicago
Sun, W., Wang, Z., Xu, Q., Sun, H., Liu, X., Yang, J., Hong, R."The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2199-2205. https://doi.org/10.3892/etm.2019.7165
Copy and paste a formatted citation
x
Spandidos Publications style
Sun W, Wang Z, Xu Q, Sun H, Liu X, Yang J and Hong R: The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice. Exp Ther Med 17: 2199-2205, 2019.
APA
Sun, W., Wang, Z., Xu, Q., Sun, H., Liu, X., Yang, J., & Hong, R. (2019). The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice. Experimental and Therapeutic Medicine, 17, 2199-2205. https://doi.org/10.3892/etm.2019.7165
MLA
Sun, W., Wang, Z., Xu, Q., Sun, H., Liu, X., Yang, J., Hong, R."The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice". Experimental and Therapeutic Medicine 17.3 (2019): 2199-2205.
Chicago
Sun, W., Wang, Z., Xu, Q., Sun, H., Liu, X., Yang, J., Hong, R."The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2199-2205. https://doi.org/10.3892/etm.2019.7165
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team