Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2019 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis

  • Authors:
    • Yanna Cheng
    • Xiaojuan Yang
    • Xijun Zhang
    • Zhi An
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Yanan University Affiliated Hospital, Yanan, Shaanxi 716000, P.R. China, Department of Nephrology, Yanan People's Hospital, Yanan, Shaanxi 716000, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2279-2283
    |
    Published online on: January 14, 2019
       https://doi.org/10.3892/etm.2019.7168
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Expression levels of interleukin-17 (IL-17) and IL-34 was investigated to analyze the influencing factors for prognosis in patients with lupus nephritis (LN). Clinical data of 45 patients (LN group) treated and diagnosed with LN via renal biopsy in Yanan University Affiliated Hospital from October 2010 to October 2012 and 50 healthy subjects (control group) were analyzed retrospectively. Levels of serum IL-17 and IL-34 were detected via enzyme-linked immunosorbent assay. Correlations of serum IL-17 and IL-34 with urinary protein in LN patients were analyzed via Pearson correlation analysis. Univariate survival analysis was performed using the Kaplan-Meier method, and multivariate analysis was performed for LN prognosis using the Cox proportional hazards model. Levels of serum IL-34 and IL-17 in patients in LN group were significantly higher than those in control group (P<0.001). Serum IL-17 and IL-34 in LN patients were positively correlated with urinary protein (r= 0.436 and 0.714, P<0.05). Adverse factors affecting the prognosis of 45 LN patients including age, hemoglobin, platelet, blood uric acid, urinary protein, IL-17 and IL-34, showing statistically significant differences (P<0.05). Age, hemoglobin, blood uric acid, urinary protein, IL-17 and IL-34 were independent risk factors for poor prognosis of LN (P<0.05). The inflammatory factors IL-17 and IL-34 are highly expressed in the serum of LN patients. Levels of serum IL-17 and IL-34 in LN patients have positive correlations with urinary protein. Results of univariate and multivariate Cox regression analyses reveal that age, hemoglobin, blood uric acid, urinary protein, IL-17 and IL-34 are independent risk factors for poor prognosis of LN. IL-17 and IL-34 can therefore serve as effective indexes for clinical diagnosis, treatment and prognosis of LN.
View Figures

Figure 1

View References

1 

Rönnblom L and Pascual V: The innate immune system in SLE: Type I interferons and dendritic cells. Lupus. 17:394–399. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Mackay M, Stanevsky A, Wang T, Aranow C, Li M, Koenig S, Ravetch JV and Diamond B: Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. J Exp Med. 203:2157–2164. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Faurschou M, Starklint H, Halberg P and Jacobsen S: Prognostic factors in lupus nephritis: Diagnostic and therapeutic delay increases the risk of terminal renal failure. J Rheumatol. 33:1563–1569. 2006.PubMed/NCBI

4 

Bajaj S, Albert L, Gladman DD, Urowitz MB, Hallett DC and Ritchie S: Serial renal biopsy in systemic lupus erythematosus. J Rheumatol. 27:2822–2826. 2000.PubMed/NCBI

5 

Ramos-Casals M, Nardi N, Lagrutta M, Brito-Zerón P, Bové A, Delgado G, Cervera R, Ingelmo M and Font J: Vasculitis in systemic lupus erythematosus: Prevalence and clinical characteristics in 670 patients. Medicine (Baltimore). 85:95–104. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Heimovski FE, Simioni JA and Skare TL: Systemic lupus erythematosus and Raynaud's phenomenon. An Bras Dermatol. 90:837–840. 2015. View Article : Google Scholar : PubMed/NCBI

7 

D'Cruz DP, Mellor-Pita S, Joven B, Sanna G, Allanson J, Taylor J, Khamashta MA and Hughes GR: Transverse myelitis as the first manifestation of systemic lupus erythematosus or lupus-like disease: Good functional outcome and relevance of antiphospholipid antibodies. J Rheumatol. 31:280–285. 2004.PubMed/NCBI

8 

Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D, et al: Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science. 320:807–811. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Foucher ED, Blanchard S, Preisser L, Garo E, Ifrah N, Guardiola P, Delneste Y and Jeannin P: IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ. PLoS One. 8:e560452013. View Article : Google Scholar : PubMed/NCBI

10 

Chalmers SA, Chitu V, Ramanujam M and Putterman C: Therapeutic targeting of macrophages in lupus nephritis. Discov Med. 20:43–49. 2015.PubMed/NCBI

11 

Roussel L, Houle F, Chan C, Yao Y, Bérubé J, Olivenstein R, Martin JG, Huot J, Hamid Q, Ferri L, et al: IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol. 184:4531–4537. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Zhao XF, Pan HF, Yuan H, Zhang WH, Li XP, Wang GH, Wu GC, Su H, Pan FM, Li WX, et al: Increased serum interleukin 17 in patients with systemic lupus erythematosus. Mol Biol Rep. 37:81–85. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Hsu HC, Yang P, Wang J, Wu Q, Myers R, Chen J, Yi J, Guentert T, Tousson A, Stanus AL, et al: Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol. 9:166–175. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Sprangers B, Monahan M and Appel GB: Diagnosis and treatment of lupus nephritis flares - an update. Nat Rev Nephrol. 8:709–717. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Mok CC, Ying KY, Tang S, Leung CY, Lee KW, Ng WL, Wong RW and Lau CS: Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis. Arthritis Rheum. 50:2559–2568. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Saxena R, Mahajan T and Mohan C: Lupus nephritis: Current update. Arthritis Res Ther. 13:2402011. View Article : Google Scholar : PubMed/NCBI

17 

Balow JE, Waldman M and Austin HA: Lupus nephritis. Therapy in Nephrology & Hypertension. Saunders; Philadelphia, PA: pp. 157–171. 2008, View Article : Google Scholar

18 

Bethunaickan R, Berthier CC, Zhang W, Kretzler M and Davidson A: Comparative transcriptional profiling of 3 murine models of SLE nephritis reveals both unique and shared regulatory networks. PLoS One. 8:e774892013. View Article : Google Scholar : PubMed/NCBI

19 

Susianti H, Iriane VM, Dharmanata S, Handono K, Widijanti A, Gunawan A and Kalim H: Analysis of urinary TGF-β1, MCP-1, NGAL, and IL-17 as biomarkers for lupus nephritis. Pathophysiology. 22:65–71. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Menke J, Rabacal WA, Byrne KT, Iwata Y, Schwartz MM, Stanley ER, Schwarting A and Kelley VR: Circulating CSF-1 promotes monocyte and macrophage phenotypes that enhance lupus nephritis. J Am Soc Nephrol. 20:2581–2592. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Shen K, Yu Y, Tang Z, Liu Z and Li L: The prognosis of biopsy-proven lupus nephritis in Chinese patients: Long term follow-up of 86 cases. Chin Med J (Engl). 110:502–507. 1997.PubMed/NCBI

22 

Daniel L, Sichez H, Giorgi R, Dussol B, Figarella-Branger D, Pellissier JF and Berland Y: Tubular lesions and tubular cell adhesion molecules for the prognosis of lupus nephritis. Kidney Int. 60:2215–2221. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Nee R, Jindal RM, Little D, Ramsey-Goldman R, Agodoa L, Hurst FP and Abbott KC: Racial differences and income disparities are associated with poor outcomes in kidney transplant recipients with lupus nephritis. Transplantation. 95:1471–1478. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Yap DY, Tang CS, Ma MK, Lam MF and Chan TM: Survival analysis and causes of mortality in patients with lupus nephritis. Nephrol Dial Transplant. 27:3248–3254. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Sánchez-Lozada LG, Tapia E, López-Molina R, Nepomuceno T, Soto V, Avila-Casado C, Nakagawa T, Johnson RJ, Herrera-Acosta J and Franco M: Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Am J Physiol Renal Physiol. 292:F1238–F1244. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Wu T, Fu Y, Brekken D, Yan M, Zhou XJ, Vanarsa K, Deljavan N, Ahn C, Putterman C and Mohan C: Urine proteome scans uncover total urinary protease, PGDS, SAP and SOD as potential markers of lupus nephritis. J Immunol. 184:2183–2193. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Yang X, Zhang X and An Z: Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis. Exp Ther Med 17: 2279-2283, 2019.
APA
Cheng, Y., Yang, X., Zhang, X., & An, Z. (2019). Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis. Experimental and Therapeutic Medicine, 17, 2279-2283. https://doi.org/10.3892/etm.2019.7168
MLA
Cheng, Y., Yang, X., Zhang, X., An, Z."Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis". Experimental and Therapeutic Medicine 17.3 (2019): 2279-2283.
Chicago
Cheng, Y., Yang, X., Zhang, X., An, Z."Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2279-2283. https://doi.org/10.3892/etm.2019.7168
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Yang X, Zhang X and An Z: Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis. Exp Ther Med 17: 2279-2283, 2019.
APA
Cheng, Y., Yang, X., Zhang, X., & An, Z. (2019). Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis. Experimental and Therapeutic Medicine, 17, 2279-2283. https://doi.org/10.3892/etm.2019.7168
MLA
Cheng, Y., Yang, X., Zhang, X., An, Z."Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis". Experimental and Therapeutic Medicine 17.3 (2019): 2279-2283.
Chicago
Cheng, Y., Yang, X., Zhang, X., An, Z."Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2279-2283. https://doi.org/10.3892/etm.2019.7168
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team