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Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris

  • Authors:
    • Mi Rim Lee
    • Ji Eun Kim
    • Jun Young Choi
    • Jin Ju Park
    • Hye Ryeong Kim
    • Bo Ram Song
    • Young Whan Choi
    • Kyung Mi Kim
    • Hyunkeun Song
    • Dae Youn Hwang
  • View Affiliations / Copyright

    Affiliations: Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, Gyeongsangnam 50463, Republic of Korea, Department of Horticultural Bioscience, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, Gyeongsangnam 50463, Republic of Korea, Life Science Research Institute, Novarex Co., Ltd., Chungju, Chungcheong 28126, Republic of Korea, Biomedical Science Institute, Changwon National University, Changwon, Gyeongsangnam 51140, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2185-2193
    |
    Published online on: January 21, 2019
       https://doi.org/10.3892/etm.2019.7191
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Abstract

The therapeutic effects of mulberry (Morus alba) leaves on lipid metabolism, including lipogenesis, lipolysis and hyperlipidemia are widely known, although their fermented products are yet to be applied. To investigate the therapeutic effects of a novel extract of mulberry leaves fermented with Cordyceps militaris (EMfC) on lipid metabolism, the lipid profile of serum, lipid accumulation, lipolytic activity and lipogenesis regulation were measured in high fat diet (HFD)‑induced obese C57BL/6 mice treated with EMfC for 12 weeks. Briefly, the concentrations of low‑density lipoprotein, triglyceride, total cholesterol and glucose significantly decreased in the serum of the HFD+EMfC treated group when compared with the HFD+Vehicle treated group, while the levels of high‑density lipoprotein increased in the HFD+EMfC group. The amount of abdominal fat and the size of adipocytes were significantly lower in the HFD+EMfC treated group when compared with the HFD+Vehicle treated group. The weight and number of lipid droplets of liver tissue exhibited a similar decrease. Furthermore, the mRNA levels of peroxisome proliferator‑activated receptor‑γ for adipogenesis as well as adipocyte protein 2 and Fas cell surface death receptor for lipogenesis reduced following EMfC treatment for 12 weeks. Phosphorylation of perilipin and hormone‑sensitive lipase, and in the adipose triglyceride lipase expression showed a significant increase in the HFD+EMfC treated group. These results indicated that EMfC may prevent fat accumulation in the HFD‑induced obese C57BL/6 mice through the inhibition of lipogenesis and by stimulating lipolysis. Thus, the results provide evidence for the potential use of EMfC as an anti‑obesity complex in the treatment of obesity.
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View References

1 

Haslam DW and James WP: Obesity. Lancet. 366:1197–1209. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Després JP and Lemieux I: Abdominal obesity and metabolic syndrome. Nature. 444:881–887. 2006. View Article : Google Scholar : PubMed/NCBI

3 

NCD Risk Factor Collaboration (NCD-RisC): Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 387:1513–1530. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Maguire T and Haslam D: The Obesity Epidemic and its Management. Matthew Wright: Pharmaceutical Press; London: pp. 264–267. 2010

5 

Pittler MH, Schmidt K and Ernst E: Adverse events of herbal food supplements for body weight reduction: Systematic review. Obes Rev. 6:93–111. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Gunjal S, Ankola AV and Bhat K: In vitro antibacterial activity of ethanolic extract of Morus alba leaf against periodontal pathogens. Indian J Dent Res. 26:533–536. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Raman ST, Ganeshan AK, Chen C, Jin C, Li SH, Chen HJ and Gui Z: In vitro in vivo antioxidant activity of flavonoid extracted from mulberry fruit (Morus alba L.). Pharmacogn Mag. 12:128–133. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Wang Y, Xiang L, Wang C, Tang C and He X: Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract. PLoS One. 8:e711442008. View Article : Google Scholar

9 

Jo SP, Kim JK and Lim YH: Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet. Food Chem Toxicol. 65:213–218. 2014. View Article : Google Scholar : PubMed/NCBI

10 

El-Beshbishy HA, Singab AN, Sinkkonen J and Pihlaja K: Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci. 78:2724–2733. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Eo HJ, Park JH, Park GH, Lee MH, Lee JR, Koo JS and Jeong JB: Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark. BMC Complement Altern Med. 14:2002014. View Article : Google Scholar : PubMed/NCBI

12 

Chan EW, Lye PY and Wong SK: Phytochemistry, pharmacology, and clinical trials of Morus alba. Chin J Nat Med. 14:17–30. 2016.PubMed/NCBI

13 

Kobayashi Y, Miyazawa M, Kamei A, Abe K and Kojima T: Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: Induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress. Biosci Biotechnol Biochem. 74:2385–2395. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Yang SJ, Park NY and Lim Y: Anti-adipogenic effect of mulberry leaf ethanol extract in 3T3-L1 adipocytes. Nutr Res Pract. 8:613–617. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ann JY, Eo HY and Lim YS: Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice. Genes Nutr. 10:462015. View Article : Google Scholar : PubMed/NCBI

16 

Naowaboot J, Pannangpetch P, Kukongviriyapan V, Prawan A, Kukongviriyapan U and Itharat A: Mulberry leaf extract stimulates glucose uptake and GLUT4 translocation in rat adipocytes. Am J Chin Med. 40:163–175. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Sugimoto M, Arai H, Taura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H, Akamizu T, Ueda Y, et al: Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice. Atherosclerosis. 204:388–394. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Sung GH, Hywel-Jones NL, Sung JM, Luangsa-Ard JJ, Shrestha B and Spatafora JW: Phylogenetic classification of Cordyceps and the clavicipitaceous fungi. Stud Mycol. 57:5–59. 2007. View Article : Google Scholar : PubMed/NCBI

19 

De Silva DD, Rapior S, Sudarman E, Stadler M, Xu J, Alias SA and Hyde KD: Bioactive metabolites from macrofungi: Ethnopharmacology, biological activities and chemistry. Fungal Divers. 62:1–40. 2013. View Article : Google Scholar

20 

De Silva DD, Rapior S, Fons F, Bahkali AH and Hyde KD: Medicinal mushrooms in supportive cancer therapies: An approach to anti-cancer effects and putative mechanisms of action. Fungal Divers. 55:1–35. 2012. View Article : Google Scholar

21 

Pao HY, Pan BS, Leu SF and Huang BM: Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C Pathway. J Agric Food Chem. 60:4905–4913. 2102. View Article : Google Scholar

22 

Kim JR, Yeon SH, Kim HS and Ahn YJ: Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body of Cordyceps militaris. Pest Manag Sci. 58:713–717. 2012. View Article : Google Scholar

23 

Ramesh T, Yoo SK, Kim SW, Hwang SY, Sohn SH, Kim IW and Kim SK: Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats. Exp Gerontol. 47:979–987. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Guo P, Kai Q, Gao J, Lian ZQ, Wu CM, Wu CA and Zhu HB: Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J Pharm Sci. 113:395–403. 2010. View Article : Google Scholar

25 

Kim SS, Lim KS, Kim HJ, Chong MS, Cho HE, Choi YH, et al: Effects of extracts from mixed culture with Tricholoma Matsutake mycelium and Cordyceps Militaris mycelium on mlood glucose in streptozotocin-induced diabetic rats. Korean J Orient Physiol Pathol. 22:365–370. 2008.

26 

Hung YP and Lee CL: Higher anti-liver fibrosis effect of cordyceps militaris-fermented product cultured with deep ocean water via inhibiting proinflammatory factors and fibrosis-related factors expressions. Mar Drugs. 15(pii): E1682017. View Article : Google Scholar : PubMed/NCBI

27 

Lee MR, Kim JE, Yun WB, Choi JY, Park JJ, Kim HR, Song BR, Choi YW, Kim KM and Hwang DY: Lipolytic effect of novel extracts from mulberry (Morus alba) leaves fermented with Cordyceps militaris in the primary adipocytes derived from SD rats. Lab Anim Res. 33:270–279. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Hofbauer KG, Nicholson JR and Boss O: The obesity epidemic: Current and future pharmacological treatments. Annu Rev Pharmacol Toxicol. 47:565–592. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Sharma B and Henderson DC: Sibutramine: Current status as an anti-obesity drug and its future perspectives. Expert Opin Pharmacother. 9:2161–2173. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Lean ME: Pathophysiology of obesity. Proc Nutr Soc. 59:331–336. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Apostolopoulou M, Savopoulos C, Michalakis K, Coppack S, Dardavessis T and Hatzitolios A: Age, weight and obesity. Maturitas. 71:115–119. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Morimoto C, Kameda K, Tsujita T and Okuda H: Relationships between lipolysis induced by various lipolytic agents and hormone-sensitive lipase in rat fat cells. J Lipid Res. 42:120–127. 2001.PubMed/NCBI

34 

Bray GA: Drug treatment of obesity. Rev Endocr Metab Disord. 2:403–418. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Mayer MA, Höcht C, Puyó A and Taira CA: Recent advances in obesity pharmacotherapy. Curr Clin Pharmacol. 4:53–61. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Vázquez-Vela ME, Torres N and Tovar AR: White adipose tissue as endocrine organ and its role in obesity. Arch Med Res. 39:715–728. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Schoonjans K, Staels B and Auwerx J: The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta. 1302:93–109. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Rosen ED, Walkey CJ, Puigserver P and Spiegelman BM: Transcriptional regulation of adipogenesis. Genes Dev. 14:1293–1307. 2000.PubMed/NCBI

39 

Kliewer SA and Willson TM: The nuclear receptor PPARgamma-bigger than fat. Curr Opin Genet Dev. 8:576–581. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Spiegelman BM: PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor. Diabetes. 47:507–514. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Boizard M, Le Liepvre X, Lemarchand P, Foufelle F, Ferré P and Dugail I: Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. J Biol Chem. 273:29164–29171. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Coe NR and Bernlohr DA: Physiological properties and functions of intracellular fatty acid-binding proteins. Biochim Biophys Acta. 1391:287–306. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A and Zechner R: Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 306:1383–1386. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, et al: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 312:734–737. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C and Sul HS: Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes. 58:855–866. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR and Londos C: The central role of perilipin a in lipid metabolism and adipocyte lipolysis. IUBMB Life. 56:379–385. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Marcelin G and Chua S Jr: Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity. Curr Opin Pharmacol. 10:588–593. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee MR, Kim JE, Choi JY, Park JJ, Kim HR, Song BR, Choi YW, Kim KM, Song H, Hwang DY, Hwang DY, et al: Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris . Exp Ther Med 17: 2185-2193, 2019.
APA
Lee, M.R., Kim, J.E., Choi, J.Y., Park, J.J., Kim, H.R., Song, B.R. ... Hwang, D.Y. (2019). Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris . Experimental and Therapeutic Medicine, 17, 2185-2193. https://doi.org/10.3892/etm.2019.7191
MLA
Lee, M. R., Kim, J. E., Choi, J. Y., Park, J. J., Kim, H. R., Song, B. R., Choi, Y. W., Kim, K. M., Song, H., Hwang, D. Y."Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris ". Experimental and Therapeutic Medicine 17.3 (2019): 2185-2193.
Chicago
Lee, M. R., Kim, J. E., Choi, J. Y., Park, J. J., Kim, H. R., Song, B. R., Choi, Y. W., Kim, K. M., Song, H., Hwang, D. Y."Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris ". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2185-2193. https://doi.org/10.3892/etm.2019.7191
Copy and paste a formatted citation
x
Spandidos Publications style
Lee MR, Kim JE, Choi JY, Park JJ, Kim HR, Song BR, Choi YW, Kim KM, Song H, Hwang DY, Hwang DY, et al: Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris . Exp Ther Med 17: 2185-2193, 2019.
APA
Lee, M.R., Kim, J.E., Choi, J.Y., Park, J.J., Kim, H.R., Song, B.R. ... Hwang, D.Y. (2019). Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris . Experimental and Therapeutic Medicine, 17, 2185-2193. https://doi.org/10.3892/etm.2019.7191
MLA
Lee, M. R., Kim, J. E., Choi, J. Y., Park, J. J., Kim, H. R., Song, B. R., Choi, Y. W., Kim, K. M., Song, H., Hwang, D. Y."Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris ". Experimental and Therapeutic Medicine 17.3 (2019): 2185-2193.
Chicago
Lee, M. R., Kim, J. E., Choi, J. Y., Park, J. J., Kim, H. R., Song, B. R., Choi, Y. W., Kim, K. M., Song, H., Hwang, D. Y."Anti‑obesity effect in high‑fat‑diet‑induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris ". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2185-2193. https://doi.org/10.3892/etm.2019.7191
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