Open Access

Differential composition of gut microbiota among healthy volunteers, morbidly obese patients and post‑bariatric surgery patients

  • Authors:
    • Fu‑Gang Wang
    • Ri‑Xing Bai
    • Wen‑Mao Yan
    • Ming Yan
    • Ling‑Yue Dong
    • Mao‑Min Song
  • View Affiliations

  • Published online on: January 25, 2019     https://doi.org/10.3892/etm.2019.7200
  • Pages: 2268-2278
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The modulation of the gut microbiota was recently deemed one of the mechanisms responsible for the excellent outcomes of bariatric surgery. However, to date, only few studies have assessed this, and they have high heterogeneity. In the present study, next‑generation 16S ribosomal DNA amplicon sequencing was used to characterize the gut microbiota of healthy volunteers, as well as patients prior to and after sleeve gastrectomy (SG) or Roux‑en‑Y gastric bypass (RYGB). Significant differences in α diversity, β diversity and species were identified between the different groups/time‑points. The results demonstrated excellent outcomes of SG and RYGB. The β diversity was lower in healthy volunteers compared with that in morbidly obese patients with or without type 2 diabetes mellitus. At 3 months after SG, the α diversity was increased and the β diversity was decreased. The abundance of certain species changed significantly after SG and RYGB. It was also revealed that the abundance of certain microbes was significantly correlated with the body mass index, fasting blood glucose and glycosylated haemoglobin. It may be concluded that bariatric surgery may cause obvious alterations in the gut microbiota and compared with healthy volunteers and obese patients without bariatric surgery, the microbiota composition of post‑bariatric surgery has unique characteristics. However, studies with a larger cohort and longer follow‑up may be required to confirm these results.
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March-2019
Volume 17 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang FG, Bai RX, Yan WM, Yan M, Dong LY and Song MM: Differential composition of gut microbiota among healthy volunteers, morbidly obese patients and post‑bariatric surgery patients. Exp Ther Med 17: 2268-2278, 2019
APA
Wang, F., Bai, R., Yan, W., Yan, M., Dong, L., & Song, M. (2019). Differential composition of gut microbiota among healthy volunteers, morbidly obese patients and post‑bariatric surgery patients. Experimental and Therapeutic Medicine, 17, 2268-2278. https://doi.org/10.3892/etm.2019.7200
MLA
Wang, F., Bai, R., Yan, W., Yan, M., Dong, L., Song, M."Differential composition of gut microbiota among healthy volunteers, morbidly obese patients and post‑bariatric surgery patients". Experimental and Therapeutic Medicine 17.3 (2019): 2268-2278.
Chicago
Wang, F., Bai, R., Yan, W., Yan, M., Dong, L., Song, M."Differential composition of gut microbiota among healthy volunteers, morbidly obese patients and post‑bariatric surgery patients". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2268-2278. https://doi.org/10.3892/etm.2019.7200