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Article

Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway

  • Authors:
    • Xiangjun Sun
    • Mingchun Wang
    • Fenghua Zhang
    • Xiao Kong
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China, Department of Surgery, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China
  • Pages: 2334-2340
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    Published online on: January 29, 2019
       https://doi.org/10.3892/etm.2019.7211
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Abstract

The present study aimed to elucidate the underlying mechanism of neuroepithelial cell transforming 1 (NET‑1), a member of the Ras homolog gene family, in hepatocellular carcinoma (HCC). To determine the association between the expression of NET‑1 and the proliferation and migration of MHCC97‑H cells, the cells were transfected with NET‑1 small interfering (si)RNA and si negative control. Following transfection with NET‑1 siRNA, the proliferation rate of MHCC97‑H cells decreased significantly and the percentage of apoptotic cells increased. The HCC cell line MHCC97‑H was used in the present study as it exhibited an increased expression level of NET‑1 compared with the MHCC97‑L cell line. Expression levels of apoptosis‑associated proteins including apoptosis regulator Bax (Bax), cyclinD1, apoptosis regulator Bcl‑2 (Bcl‑2) and caspase‑3 were determined. Expression levels of phosphoinositide 3‑kinase (PI3K) and protein kinase B (AKT) and their phosphorylated forms were also measured by western blotting. Following NET‑1 knockdown, the expression of Bax and cyclinD1 decreased, the expression of Bcl‑2 and caspase‑3 increased, and the PI3K/AKT signaling pathway was inhibited. The results of the present study suggest that inhibition of NET‑1 can suppress the progression of HCC by targeting the PI3K/AKT signaling pathway. NET‑1 expression level in HCC cells increased compared with normal liver cells.
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1 

Keeffe EB: Risk score for development of HCC: Ready for use in practice? Lancet Oncol. 12:517–519. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Furihata T, Sawada T, Kita J, Iso Y, Kato M, Rokkaku K, Shimoda M and Kubota K: Serum alpha-fetoprotein level per tumor volume reflects prognosis in patients with hepatocellular carcinoma after curative hepatectomy. Hepatogastroenterology. 55:1705–1709. 2008.PubMed/NCBI

3 

Kütting F, Schubert J, Franklin J, Bowe A, Hoffmann V, Demir M, Pelc A, Nierhoff D, Töx U and Steffen HM: Insufficient evidence of benefit regarding mortality due to albumin substitution in HCC-free cirrhotic patients undergoing large volume paracentesis. J Gastroenterol Hepatol. 32:327–338. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Sasaki K, Firl DJ, Hashimoto K, Fujiki M, Diago-Uso T, Quintini C, Eghtesad B, Fung JJ, Aucejo FN and Miller CM: Development and validation of the HALT-HCC score to predict mortality in liver transplant recipients with hepatocellular carcinoma: A retrospective cohort analysis. Lancet Gastroenterol Hepatol. 2:595–603. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Schwarz L, Bubenheim M, Zemour J, Herrero A, Muscari F, Ayav A, Riboud R, Ducerf C, Regimbeau JM, Tranchart H, et al: Bleeding recurrence and mortality following interventional management of spontaneous HCC rupture: Results of a multicenter European study. World J Surg. 42:225–232. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Sun LY, Zhang H, Li ZL, Li C, Wang MD and Yang T: How to predict global trends in HCC mortality if neglecting more than half the world's cases? J Hepatol. 67:887–888. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Cao W, Li J, Hu C, Shen J, Liu X, Xu Y and Ye Z: Symptom clusters and symptom interference of HCC patients undergoing TACE: A cross-sectional study in China. Support Care Cancer. 21:475–483. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Chen M, Therneau T, Orsini LS and Qiao YL: Design and rationale of the HCC BRIDGE study in China: A longitudinal, multicenter cohort trial in hepatocellular carcinoma. BMC Gastroenterol. 11:532011. View Article : Google Scholar : PubMed/NCBI

9 

Li GJ, Harrison TJ, Yang JY, Chen QY, Wang XY and Fang ZL: Combined core promoter mutations and pre-S deletion of HBV may not increase the risk of HCC: A geographical epidemiological study in Guangxi, China. Liver Int. 33:936–943. 2013. View Article : Google Scholar : PubMed/NCBI

10 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Feng YM, Feng CW, Chen SC and Hsu CD: Unexpected remission of hepatocellular carcinoma (HCC) with lung metastasis to the combination therapy of thalidomide and cyproheptadine: Report of two cases and a preliminary HCC cell line study. BMJ Case Rep. 2012(bcr2012007180)2012.

12 

Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 25:666–681. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Hou YQ, Yao Y, Bao YL, Song ZB, Yang C, Gao XL, Zhang WJ, Sun LG, Yu CL, Huang YX, et al: Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/Foxo signal pathway in HCC cells. Oxid Med Cell Longev. 2016:49416232016. View Article : Google Scholar : PubMed/NCBI

14 

Wang Y, Huang X, Han J, Zheng W and Ma W: Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway. Afr J Tradit Complement Altern Med. 10:251–257. 2012.PubMed/NCBI

15 

Serru V, Dessen P, Boucheix C and Rubinstein E: Sequence and expression of seven new tetraspans. Biochim Biophys Acta. 1478:159–163. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Ji ZJ, Wang JL and Chen L: Inhibition of skin squamous cell carcinoma proliferation and promote apoptosis by dual silencing of NET-1 and survivin. Oncol Rep. 34:811–822. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Wu B, Liang X, Jing H, Han X, Sun Y, Guo C, Liu Y and Cheng W: Effect of NET-1 siRNA conjugated sub-micron bubble complex combined with low-frequency ultrasound exposure in gene transfection. Oncotarget. 9:4150–4160. 2017.PubMed/NCBI

18 

Zuo Y, Ulu A, Chang JT and Frost JA: Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen-mediated mammary gland tumorigenes and metastasis. Breast Cancer Res. 20:412018. View Article : Google Scholar : PubMed/NCBI

19 

Gabitova G and Burke NJ: Improving healthcare empowerment through breast cancer patient navigation: A mixed methods evaluation in a safety-net setting. BMC Health Serv Res. 14:4072014. View Article : Google Scholar : PubMed/NCBI

20 

Wheelock AE, Bock MA, Martin EL, Hwang J, Ernest ML, Rugo HS, Esserman LJ and Melisko ME: SIS. NET: A randomized controlled trial evaluating a web-based system for symptom management after treatment of breast cancer. Cancer. 121:893–899. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Shen SQ, Li K, Zhu N and Nakao A: Expression and clinical significance of NET-1 and PCNA in hepatocellular carcinoma. Med Oncol. 25:341–345. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Fang L, Zhu J, Ma Y, Hong C, Xiao S and Jin L: Neuroepithelial transforming gene 1 functions as a potential prognostic marker for patients with non-small cell lung cancer. Mol Med Rep. 12:7439–7446. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Sun CK, Chua MS, He J and So SK: Suppression of glypican 3 inhibits growth of hepatocellular carcinoma cells through up-regulation of TGF-β2. Neoplasia. 13:735–747. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M and Rodés J; EASL Panel of Experts on HCC: Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European association for the study of the liver. J Hepatol. 35:421–430. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Hu L, Lau SH, Tzang CH, Wen JM, Wang W, Xie D, Huang M, Wang Y, Wu MC, Huang JF, et al: Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene. 23:298–302. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Zhao XL, Sun T, Che N, Sun D, Zhao N, Dong XY, Gu Q, Yao Z and Sun BC: Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1. J Cell Mol Med. 15:691–700. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Lauridsen HM, Pellowe AS, Ramanathan A, Liu R, Miller-Jensen K, McNiff JM, Pober JS and Gonzalez AL: Tumor necrosis factor-α and IL-17A activation induces pericyte-mediated basement membrane remodeling in human neutrophilic dermatoses. Am J Pathol. 187:1893–1906. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Ma YF, Chen C, Li D, Liu M, Lv ZW, Ji Y and Xu J: Targeting of interleukin (IL)-17A inhibits PDL1 expression in tumor cells and induces anticancer immunity in an estrogen receptor-negative murine model of breast cancer. Oncotarget. 8:7614–7624. 2017.PubMed/NCBI

29 

Xu LL, Li ZJ, Niu XL and Deng WM: The mechanisms of IL-17A on promoting tumor metastasis. Int Rev Immunol. 36:360–369. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Li J, Lau GK, Chen L, Dong SS, Lan HY, Huang XR, Li Y, Luk JM, Yuan YF and Guan XY: Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression. PLoS One. 6:e218162011. View Article : Google Scholar : PubMed/NCBI

31 

Tsai WC, Hsu PW, Lai TC, Chau GY, Lin CW, Chen CM, Lin CD, Liao YL, Wang JL, Chau YP, et al: MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology. 49:1571–1582. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Ding SJ, Li Y, Shao XX, Zhou H, Zeng R, Tang ZY and Xia QC: Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials. Proteomics. 4:982–994. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Song P, Bao H, Yu Y, Xue Y, Yun D, Zhang Y, He Y, Liu Y, Liu Q, Lu H, et al: Comprehensive profiling of metastasis-related proteins in paired hepatocellular carcinoma cells with different metastasis potentials. Proteomics Clin Appl. 3:841–852. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Chen L, Wang Z, Zhan X, Li DC, Zhu YY and Zhu J: Association of NET-1 gene expression with human hepatocellular carcinoma. Int J Surg Pathol. 15:346–353. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout GB and Bahar I: Bistability in apoptosis: Roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J. 90:1546–1559. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Prokop A, Wieder T, Sturm I, Essmann F, Seeger K, Wuchter C, Ludwig WD, Henze G, Dörken B and Daniel PT: Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo. Leukemia. 14:1606–1613. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Manero F, Gautier F, Gallenne T, Cauquil N, Grée D, Cartron PF, Geneste O, Grée R, Vallette FM and Juin P: The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res. 66:2757–2764. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Raisova M, Hossini AM, Eberle J, Riebeling C, Wieder T, Sturm I, Daniel PT, Orfanos CE and Geilen CC: The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis. J Invest Dermatol. 117:333–340. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Del Bufalo D, Biroccio A, Leonetti C and Zupi G: Bcl-2 overexpression enhances the metastatic potential of a human breast cancer line. FASEB J. 11:947–953. 1997. View Article : Google Scholar : PubMed/NCBI

40 

Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M and Aggarwal BB: Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene. 21:8852–8861. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Fu M, Wang C, Li Z, Sakamaki T and Pestell RG: Minireview: Cyclin D1: Normal and abnormal functions. Endocrinology. 145:5439–5447. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Aouacheria A, Cunningham KW, Hardwick JM, Palková Z, Powers T, Severin FF and Váchová L: Comment on ‘Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death’. Science. 360(eaar6910)2018.PubMed/NCBI

43 

Shlezinger N, Irmer H, Dhingra S, Beattie SR, Cramer RA, Braus GH, Sharon A and Hohl TM: Response to comment on ‘Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death’. Science. 360(eaas9457)2018.PubMed/NCBI

44 

Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA and Moskowitz MA: Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci USA. 99:15188–15193. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Richardson-Burns SM, Kominsky DJ and Tyler KL: Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol. 8:365–380. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Fu Y, Ye X, Lee M, Rankin G and Chen YC: Prodelphinidins isolated from Chinese bayberry leaves induces apoptosis via the p53-dependent signaling pathways in OVCAR-3 human ovarian cancer cells. Oncol Lett. 13:3210–3218. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Pidugu VR, Yarla NS, Bishayee A, Kalle AM and Satya AK: Novel histone deacetylase 8-selective inhibitor 1,3,4-oxadiazole-alanine hybrid induces apoptosis in breast cancer cells. Apoptosis. 22:1394–1403. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Zhou M, Liu X, Li Z, Huang Q, Li F and Li CY: Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. Int J Cancer. 143:921–930. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Persad R, Liu C, Wu TT, Houlihan PS, Hamilton SR, Diehl AM and Rashid A: Overexpression of caspase-3 in hepatocellular carcinomas. Mod Pathol. 17:861–867. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Brunet A, Datta SR and Greenberg ME: Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol. 11:297–305. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Franke TF, Hornik CP, Segev L, Shostak GA and Sugimoto C: PI3K/Akt and apoptosis: Size matters. Oncogene. 22:8983–8998. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Garcia-Echeverria C and Sellers WR: Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. 27:5511–5526. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Cao J, Lv W, Wang L, Xu J, Yuan P, Huang S, He Z and Hu J: Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways. Cell Death Dis. 9:8172018. View Article : Google Scholar : PubMed/NCBI

54 

Leng J, Wang Z, Fu CL, Zhang J, Ren S, Hu JN, Jiang S, Wang YP, Chen C and Li W: NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice. Phytother Res. 32:2235–2246. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Zhang HW, Hu JJ, Fu RQ, Liu X, Zhang YH, Li J, Liu L, Li YN, Deng Q, Luo QS, et al: Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kgamma mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 8:112552018. View Article : Google Scholar : PubMed/NCBI

56 

Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D and Anania FA: Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res. 67:2497–2507. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun X, Wang M, Zhang F and Kong X: Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway. Exp Ther Med 17: 2334-2340, 2019.
APA
Sun, X., Wang, M., Zhang, F., & Kong, X. (2019). Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 17, 2334-2340. https://doi.org/10.3892/etm.2019.7211
MLA
Sun, X., Wang, M., Zhang, F., Kong, X."Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 17.3 (2019): 2334-2340.
Chicago
Sun, X., Wang, M., Zhang, F., Kong, X."Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2334-2340. https://doi.org/10.3892/etm.2019.7211
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Wang M, Zhang F and Kong X: Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway. Exp Ther Med 17: 2334-2340, 2019.
APA
Sun, X., Wang, M., Zhang, F., & Kong, X. (2019). Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 17, 2334-2340. https://doi.org/10.3892/etm.2019.7211
MLA
Sun, X., Wang, M., Zhang, F., Kong, X."Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 17.3 (2019): 2334-2340.
Chicago
Sun, X., Wang, M., Zhang, F., Kong, X."Inhibition of NET‑1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 17, no. 3 (2019): 2334-2340. https://doi.org/10.3892/etm.2019.7211
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