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Article

Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease

  • Authors:
    • Giulio Geraci
    • Dario Buccheri
    • Luca Zanoli
    • Pasquale Fatuzzo
    • Katia Di Natale
    • Marta M. Zammuto
    • Emilio Nardi
    • Calogero Geraci
    • Ettore Mancia
    • Giulia Zambelli
    • Davide Piraino
    • Salvatore S. Signorelli
    • Antonio Granata
    • Santina Cottone
    • Giuseppe Mule
  • View Affiliations / Copyright

    Affiliations: Unit of Nephrology and Hypertension‑European Society of Hypertension Excellence Centre, Paolo Giaccone University Hospital, I‑90127 Palermo, Italy, Unit of Interventional Cardiology, Hospital San Giovanni di Dio, I‑92100 Agrigento, Italy, Department of Clinical and Experimental Medicine, University of Catania, I‑95100 Catania, Italy, Department of Interventional Cardiology, Paolo Giaccone University Hospital, I‑90100 Palermo, Italy, Unit of Cardiology, S. Elia Hospital, I‑93100 Caltanissetta, Italy, Department of Nephrology and Dialysis, Hospital San Giovanni di Dio, I‑92100 Agrigento, Italy
  • Pages: 3255-3263
    |
    Published online on: February 15, 2019
       https://doi.org/10.3892/etm.2019.7279
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Abstract

Intrarenal hemodynamic alterations are independent predictors of cardiovascular events in different populations. It has been hypothesized that there is an association between renal hemodynamics and coronary atherosclerotic burden in patients with hypertension. Therefore, the present study examined the associations between renal hemodynamics, coronary atherosclerotic burden and carotid atherosclerotic disease. A total of 130 patients with hypertension aged between 30‑80 years who had been referred for an elective coronary angiography were enrolled in the present study. A duplex ultrasound of the intrarenal vasculature was performed to evaluate the resistive index (RI), pulsatility index (PI) and acceleration time (AT). The carotid intima‑media thickness was additionally assessed. A coronary angiography was performed to detect the atherosclerotic burden using the Gensini Score (GS). Based on the GS values, subjects were divided into quintiles (I: ≤9; II: 9‑17; III: 17‑30; IV: 30‑44; and V: GS >44) as well as in subjects with mild (GS ≤30) or severe coronary disease (GS >30). A weak significant difference in PI was identified among quintiles (P=0.041), whereas, RI and AT did not differ significantly. PI was associated with GS in the group with low coronary atherosclerotic burden (GS ≤30; P=0.047), whereas, no association was detected in subjects with GS >30. This association remained following adjustment for age and left ventricular ejection fraction (P=0.025). In conclusion, renal vascular alterations were associated with coronary atherosclerotic burden in patients with hypertension with mild coronary disease.
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Copy and paste a formatted citation
Spandidos Publications style
Geraci G, Buccheri D, Zanoli L, Fatuzzo P, Di Natale K, Zammuto MM, Nardi E, Geraci C, Mancia E, Zambelli G, Zambelli G, et al: Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease. Exp Ther Med 17: 3255-3263, 2019.
APA
Geraci, G., Buccheri, D., Zanoli, L., Fatuzzo, P., Di Natale, K., Zammuto, M.M. ... Mule, G. (2019). Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease. Experimental and Therapeutic Medicine, 17, 3255-3263. https://doi.org/10.3892/etm.2019.7279
MLA
Geraci, G., Buccheri, D., Zanoli, L., Fatuzzo, P., Di Natale, K., Zammuto, M. M., Nardi, E., Geraci, C., Mancia, E., Zambelli, G., Piraino, D., Signorelli, S. S., Granata, A., Cottone, S., Mule, G."Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease". Experimental and Therapeutic Medicine 17.4 (2019): 3255-3263.
Chicago
Geraci, G., Buccheri, D., Zanoli, L., Fatuzzo, P., Di Natale, K., Zammuto, M. M., Nardi, E., Geraci, C., Mancia, E., Zambelli, G., Piraino, D., Signorelli, S. S., Granata, A., Cottone, S., Mule, G."Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3255-3263. https://doi.org/10.3892/etm.2019.7279
Copy and paste a formatted citation
x
Spandidos Publications style
Geraci G, Buccheri D, Zanoli L, Fatuzzo P, Di Natale K, Zammuto MM, Nardi E, Geraci C, Mancia E, Zambelli G, Zambelli G, et al: Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease. Exp Ther Med 17: 3255-3263, 2019.
APA
Geraci, G., Buccheri, D., Zanoli, L., Fatuzzo, P., Di Natale, K., Zammuto, M.M. ... Mule, G. (2019). Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease. Experimental and Therapeutic Medicine, 17, 3255-3263. https://doi.org/10.3892/etm.2019.7279
MLA
Geraci, G., Buccheri, D., Zanoli, L., Fatuzzo, P., Di Natale, K., Zammuto, M. M., Nardi, E., Geraci, C., Mancia, E., Zambelli, G., Piraino, D., Signorelli, S. S., Granata, A., Cottone, S., Mule, G."Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease". Experimental and Therapeutic Medicine 17.4 (2019): 3255-3263.
Chicago
Geraci, G., Buccheri, D., Zanoli, L., Fatuzzo, P., Di Natale, K., Zammuto, M. M., Nardi, E., Geraci, C., Mancia, E., Zambelli, G., Piraino, D., Signorelli, S. S., Granata, A., Cottone, S., Mule, G."Renal haemodynamics and coronary atherosclerotic burden are associated in patients with hypertension and mild coronary artery disease". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3255-3263. https://doi.org/10.3892/etm.2019.7279
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