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Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials

  • Authors:
    • Shanlian Wu
    • Liang Yao
    • Peijing Yan
    • Qiangwei Bao
    • Xin Dong
    • Xingguang Liu
    • Yan Zhu
    • Xin Su
    • Aqian Wang
    • Yichao Duan
    • Kehu Yang
    • Min Zhang
    • Yunshan Cao
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China, Institute of Clinical Research and Evidence‑Based Medicine, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China, Department of Ultrasound, The Third Hospital of Gansu Province, Lanzhou, Gansu 730020, P.R. China, Department of Cardiac Surgery, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China, Department of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China, Institute of Clinical Research and Evidence‑Based Medicine, Gansu Provincial Hospital, Lanzhou, Gansu 730020, P.R. China, Department of Pathology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2985-2994
    |
    Published online on: February 15, 2019
       https://doi.org/10.3892/etm.2019.7283
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Abstract

Autologous bone marrow stem cell (BMSC) therapy is a novel option for regenerative therapy in patients with ischemic heart disease. The aim of the present meta‑analysis was to evaluate the effectiveness of BMSCs combined with coronary artery bypass grafting (CABG). The PubMed, Cochrane Library, EMBASE and Web of Science databases were searched from inception to November 22, 2017 for randomized controlled trials on BMSC therapy combined with CABG. Finally, 14 trials with a total of 596 participants were included. Data were analyzed using a random‑effects model. Compared with the control group, the BMSC therapy group exhibited an improvement in the left ventricular (LV) ejection fraction from baseline to follow‑up [mean difference (MD)=4.36%; 95% confidence interval (CI): 1.90‑6.81%; P<0.01]. Analysis of the pooled results revealed non‑significant differences in the LV end‑diastolic volume (MD=‑6.27 ml; 95% CI: ‑22.34 to 9.80 ml; P=0.44), LV end‑diastolic volume index (MD=‑15.11 ml/m2; 95% CI: ‑31.53 to 1.30 ml/m2; P=0.07), LV end‑systolic volume (MD=‑11.52 ml; 95% CI: ‑26.97 to 3.93 ml; P=0.14) and LV end‑systolic volume index (MD=‑16.56 ml/m2; 95% CI: ‑37.75 to 4.63 ml/m2; P=0.13) between the BMSC and CABG alone groups. Therefore, autologous BMSC therapy for patients undergoing CABG appears to be associated with an improvement in LV function compared with CABG alone.
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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Yao L, Yan P, Bao Q, Dong X, Liu X, Zhu Y, Su X, Wang A, Duan Y, Duan Y, et al: Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials. Exp Ther Med 17: 2985-2994, 2019.
APA
Wu, S., Yao, L., Yan, P., Bao, Q., Dong, X., Liu, X. ... Cao, Y. (2019). Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials. Experimental and Therapeutic Medicine, 17, 2985-2994. https://doi.org/10.3892/etm.2019.7283
MLA
Wu, S., Yao, L., Yan, P., Bao, Q., Dong, X., Liu, X., Zhu, Y., Su, X., Wang, A., Duan, Y., Yang, K., Zhang, M., Cao, Y."Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials". Experimental and Therapeutic Medicine 17.4 (2019): 2985-2994.
Chicago
Wu, S., Yao, L., Yan, P., Bao, Q., Dong, X., Liu, X., Zhu, Y., Su, X., Wang, A., Duan, Y., Yang, K., Zhang, M., Cao, Y."Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2985-2994. https://doi.org/10.3892/etm.2019.7283
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S, Yao L, Yan P, Bao Q, Dong X, Liu X, Zhu Y, Su X, Wang A, Duan Y, Duan Y, et al: Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials. Exp Ther Med 17: 2985-2994, 2019.
APA
Wu, S., Yao, L., Yan, P., Bao, Q., Dong, X., Liu, X. ... Cao, Y. (2019). Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials. Experimental and Therapeutic Medicine, 17, 2985-2994. https://doi.org/10.3892/etm.2019.7283
MLA
Wu, S., Yao, L., Yan, P., Bao, Q., Dong, X., Liu, X., Zhu, Y., Su, X., Wang, A., Duan, Y., Yang, K., Zhang, M., Cao, Y."Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials". Experimental and Therapeutic Medicine 17.4 (2019): 2985-2994.
Chicago
Wu, S., Yao, L., Yan, P., Bao, Q., Dong, X., Liu, X., Zhu, Y., Su, X., Wang, A., Duan, Y., Yang, K., Zhang, M., Cao, Y."Autologous bone marrow stem cell therapy for patients undergoing coronary artery bypass grafting: A meta‑analysis of 14 randomized controlled trials". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2985-2994. https://doi.org/10.3892/etm.2019.7283
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