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Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

  • Authors:
    • Shou‑Feng Zhao
    • Ai‑Min Wang
    • Xin‑Juan Yu
    • Li‑Li Wang
    • Xiao‑Na Xu
    • Guang‑Jun Shi
  • View Affiliations / Copyright

    Affiliations: Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China, Medical Examination Center, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China, Department of Hepatobiliary Surgery, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3092-3100
    |
    Published online on: February 21, 2019
       https://doi.org/10.3892/etm.2019.7291
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Abstract

Increasing evidence connects gallstone disease (GD) to cardio‑cerebrovascular disease (CVD). The aim of the present systematic review and meta‑analysis was to determine whether and to what extent an association between GD and CVD existed. PubMed, EMBASE and the Cochrane Library were systemically searched up to March 3rd, 2018. A total of 10 studies (1,272,177 participants; 13,833 records; 5 prospective cohorts and 5 retrospective cohorts) were included. It was demonstrated that GD was associated with an increased risk of incidence [hazard ratio=1.24, 95% (CI) confidence interval: 1.17‑1.31] and prevalence (unadjusted odds ratio=1.23, 95% CI: 1.21‑1.25) of CVD. In conclusion, the presence of GD was associated with an increased risk of CVD incidence and prevalence. The association may be influenced by age and sex. These findings suggest that individuals identified with cardio‑cerebrovascular disease should be evaluated for GD.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao SF, Wang AM, Yu XJ, Wang LL, Xu XN and Shi GJ: Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis. Exp Ther Med 17: 3092-3100, 2019.
APA
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., & Shi, G. (2019). Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 17, 3092-3100. https://doi.org/10.3892/etm.2019.7291
MLA
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., Shi, G."Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 17.4 (2019): 3092-3100.
Chicago
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., Shi, G."Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3092-3100. https://doi.org/10.3892/etm.2019.7291
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao SF, Wang AM, Yu XJ, Wang LL, Xu XN and Shi GJ: Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis. Exp Ther Med 17: 3092-3100, 2019.
APA
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., & Shi, G. (2019). Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 17, 3092-3100. https://doi.org/10.3892/etm.2019.7291
MLA
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., Shi, G."Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 17.4 (2019): 3092-3100.
Chicago
Zhao, S., Wang, A., Yu, X., Wang, L., Xu, X., Shi, G."Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3092-3100. https://doi.org/10.3892/etm.2019.7291
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