Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2019 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2019 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention

  • Authors:
    • Yingbo Li
    • Hongjin Chang
    • Lina Ni
    • Peng Xue
    • Caixia Li
    • Lin Yuan
    • Hailing Cui
    • Chengyong Yu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Weihai Central Hospital, Weihai, Shandong 264400, P.R. China, Department of Blood Transfusion, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China, Department of Medical Administration, Weihai Central Hospital, Weihai, Shandong 264400, P.R. China
  • Pages: 3047-3052
    |
    Published online on: February 22, 2019
       https://doi.org/10.3892/etm.2019.7294
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Effects of thrombelastogram-guided (TEG-guided) clopidogrel and aspirin on major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) were investigated. A retrospective analysis was performed on 203 patients undergoing PCI interventional therapy in the Cardiovascular Medicine of Weihai Central Hospital from February 2015 to September 2016. The patients were treated with clopidogrel and aspirin for anti-thrombus therapy. Among them, 104 patients who had TEG detection of anticoagulant effects for guiding medication were the experimental group, and 99 patients without TEG detection for guiding medication the control group. The coagulation function and the platelet inhibition rate of patients after medication were evaluated and compared between the two groups. The incidence of MACE and bleeding events of patients was counted during three months of follow-up. Patients in the experimental group had higher R (coagulation reaction time) value and K (blood clot formation time) value than those in the control group after treatment (P<0.05), and lower MA (maximum amplitude) value than those in the control group (P<0.05). Patients in the experimental group had higher postoperative platelet inhibition rate than those in the control group (P<0.05). Patients in the experimental group had lower incidence of MACE and bleeding events than those in the control group (P<0.05). Coronary heart disease (CHD) patients after PCI with the TEG-guided dose adjustment of clopidogrel have more satisfactory treatment effects than patients without the TEG guidance. TEG makes the treatment of patients more targeted and is worthy of promotion.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Reikvam H, Steien E, Hauge B, Liseth K, Hagen KG, Størkson R and Hervig T: Thrombelastography. Transfus Apheresis Sci. 40:119–123. 2009. View Article : Google Scholar

2 

Craft RM, Chavez JJ, Bresee SJ, Wortham DC, Cohen E and Carroll RC: A novel modification of the thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation. J Lab Clin Med. 143:301–309. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Patti G, Grieco D, Dicuonzo G, Pasceri V, Nusca A and Di Sciascio G: High versus standard clopidogrel maintenance dose after percutaneous coronary intervention and effects on platelet inhibition, endothelial function, and inflammation results of the ARMYDA-150 mg (antiplatelet therapy for reduction of myocardial damage during angioplasty) randomized study. J Am Coll Cardiol. 57:771–778. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Stewart RAH, Colquhoun DM, Marschner SL, Kirby AC, Simes J, Nestel PJ, Glozier N, O'Neil A, Oldenburg B, White HD, et al LIPID Study Investigators, : Persistent psychological distress and mortality in patients with stable coronary artery disease. Heart. 103:1860–1866. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chen KJ and Liu Y: Stable coronary heart disease: A choice for PCI or drug therapy - inspiration from results of a new meta-analysis. Zhongguo Zhong Xi Yi Jie He Za Zhi. 32:583–584. 2012.(In Chinese). PubMed/NCBI

6 

Khan AR, Golwala H, Tripathi A, Riaz H, Kumar A, Flaherty MP and Bhatt DL: Meta-analysis of percutaneous coronary intervention versus coronary artery bypass grafting in left main coronary artery disease. Am J Cardiol. 119:1949–1956. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Ford NF and Taubert D: Clopidogrel, CYP2C19, and a black box. J Clin Pharmacol. 53:241–248. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Duzenli MA, Ozdemir K, Aygul N, Soylu A and Tokac M: Comparison of increased aspirin dose versus combined aspirin plus clopidogrel therapy in patients with diabetes mellitus and coronary heart disease and impaired antiplatelet response to low-dose aspirin. Am J Cardiol. 102:396–400. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Zhang L, Yang J, Zhu X, Wang X, Peng L, Li X, Cheng P and Yin T: Effect of high-dose clopidogrel according to CYP2C19*2 genotype in patients undergoing percutaneous coronary intervention- a systematic review and meta-analysis. Thromb Res. 135:449–458. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Chen S, Zhang Y, Wang L, Geng Y, Gu J, Hao Q, Wang H and Qi P: Effects of dual-dose clopidogrel, clopidogrel combined with tongxinluo capsule, and ticagrelor on patients with coronary heart disease and CYP2C19*2 gene mutation after percutaneous coronary interventions (PCI). Med Sci Monit. 23:3824–3830. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Xu L, Wang L, Yang X, Li K, Sun H, Zhang D, Wang H, Li W, Ni Z, Xia K, et al: Platelet function monitoring guided antiplatelet therapy in patients receiving high-risk coronary interventions. Chin Med J (Engl). 127:3364–3370. 2014.PubMed/NCBI

12 

Louis SG, Van PY, Riha GM, Barton JS, Kunio NR, Underwood SJ, Differding JA, Rick E, Ginzburg E and Schreiber MA: Thromboelastogram-guided enoxaparin dosing does not confer protection from deep venous thrombosis: A randomized controlled pilot trial. J Trauma Acute Care Surg. 76:937–942; discussion 942–943. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Jolliffe JA, Rees K, Taylor RS, Thompson D, Oldridge N and Ebrahim S: Exercise-based rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 1:CD0018002001.

14 

Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE II, Fesmire FM, Hochman JS, Levin TN, et al 2011 Writing Group Members; ACCF/AHA Task Force Members, : 2011 ACCF/AHA focused update incorporated into the ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 123:e426–e579. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Kishan PV, Uday KC, Shobha JC, Usharani P and Chandrasekhar E: Effect of oral anti-platelet regimens on platelet aggregation using chronolog light transmittance aggregometry in coronary heart disease patients: An observational study. J Clin Diagn Res. 7:2478–2482. 2013.PubMed/NCBI

16 

Steg PG, James S, Harrington RA, Ardissino D, Becker RC, Cannon CP, Emanuelsson H, Finkelstein A, Husted S, Katus H, et al PLATO Study Group, : Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation. 122:2131–2141. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Hiller KN: Clinically relevant exaggerated pharmacodynamic response to dual antiplatelet therapy detected by Thromboelastogram® Platelet Mapping™. J Anaesthesiol Clin Pharmacol. 32:112–114. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Jain R and Sood J: Antiplatelet therapy in patients with coronary artery stents for noncardiac surgery: Role of thromboelastography. J Anaesthesiol Clin Pharmacol. 27:537–540. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Zhao SW, Wang YP, Xu LD and Gang W: The application of thromboelastogram in detection of indexes of antiplatelet therapy for coronary heart disease. J Thorac Dis. 8:3515–3520. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Yildirim F, Tuncer B, Ozbakkaloglu A, Kurdal AT, Ozturk T and Iskesen I: Thromboelastogram reduces blood use by inspecting coagulation in heart surgery. Asian Cardiovasc Thorac Ann. 24:441–444. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Berezovskaya G, Smirnova O, Malev E, Khromov-Borisov N, Klokova E, Karpenko M, Papayan L and Petrishchev N: Thrombin generation test for evaluation of antiplatelet treatment in patients with coronary artery disease after percutaneous coronary intervention. Platelets. 29:185–191. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Gurbel PA, Bliden KP, Kreutz RP, Dichiara J, Antonino MJ and Tantry US: The link between heightened thrombogenicity and inflammation: Pre-procedure characterization of the patient at high risk for recurrent events after stenting. Platelets. 20:97–104. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Gurbel PA, Bliden KP, Navickas IA, Mahla E, Dichiara J, Suarez TA, Antonino MJ, Tantry US and Cohen E: Adenosine diphosphate-induced platelet-fibrin clot strength: A new thrombelastographic indicator of long-term poststenting ischemic events. Am Heart J. 160:346–354. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Chang H, Ni L, Xue P, Li C, Yuan L, Cui H and Yu C: Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention. Exp Ther Med 17: 3047-3052, 2019.
APA
Li, Y., Chang, H., Ni, L., Xue, P., Li, C., Yuan, L. ... Yu, C. (2019). Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention. Experimental and Therapeutic Medicine, 17, 3047-3052. https://doi.org/10.3892/etm.2019.7294
MLA
Li, Y., Chang, H., Ni, L., Xue, P., Li, C., Yuan, L., Cui, H., Yu, C."Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention". Experimental and Therapeutic Medicine 17.4 (2019): 3047-3052.
Chicago
Li, Y., Chang, H., Ni, L., Xue, P., Li, C., Yuan, L., Cui, H., Yu, C."Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3047-3052. https://doi.org/10.3892/etm.2019.7294
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Chang H, Ni L, Xue P, Li C, Yuan L, Cui H and Yu C: Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention. Exp Ther Med 17: 3047-3052, 2019.
APA
Li, Y., Chang, H., Ni, L., Xue, P., Li, C., Yuan, L. ... Yu, C. (2019). Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention. Experimental and Therapeutic Medicine, 17, 3047-3052. https://doi.org/10.3892/etm.2019.7294
MLA
Li, Y., Chang, H., Ni, L., Xue, P., Li, C., Yuan, L., Cui, H., Yu, C."Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention". Experimental and Therapeutic Medicine 17.4 (2019): 3047-3052.
Chicago
Li, Y., Chang, H., Ni, L., Xue, P., Li, C., Yuan, L., Cui, H., Yu, C."Analysis of thrombelastogram-guided medication in patients with coronary heart disease after percutaneous coronary intervention". Experimental and Therapeutic Medicine 17, no. 4 (2019): 3047-3052. https://doi.org/10.3892/etm.2019.7294
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team