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miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3

  • Authors:
    • Xin‑Bang Mao
    • Yan‑Hua Cheng
    • Yan‑Ying Xu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China
    Copyright: © Mao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2945-2952
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    Published online on: February 28, 2019
       https://doi.org/10.3892/etm.2019.7327
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Abstract

Diabetic retinopathy (DR) is a chronic and progressive complication of diabetes mellitus. DR impairs sight due to neuronal and vascular dysfunction in the retina. It is critical to investigate the pathogenesis of DR to develop effective treatment. In the present study, a streptozotocin (STZ)‑induced diabetic rat model was constructed and the expression of microRNA (miR)‑204‑5p and vascular endothelial growth factor (VEGF) were determined. Immunohistochemistry, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting were employed to detect the effects of miR‑204‑5p on the expression of microtubule‑associated protein 1 light chain 3 (LC3B). RT‑qPCR analysis demonstrated that miR‑204‑5p and VEGF were significantly upregulated in the retina tissue of diabetic rats compared with the control group (P<0.01). Immunohistochemistry and western blotting revealed that the protein expression levels of LC3B‑II and the ratio of LC3B‑II/LC3B‑I were significantly suppressed in the diabetes group compared with the control (P<0.01). In retinal tissues, anti‑miR‑204‑5p treatment significantly enhanced the protein expression levels of LC3B‑II and the ratio of LC3B‑II/LC3B‑I and these levels were significantly reduced in response to miR‑204‑5p mimic treatment compared with the negative miR control (P<0.01). In rat retinal endothelial cells isolated from diabetic rats, anti‑miR‑204‑5p treatment increased the number of autophagic vacuoles, and significantly promoted LC3B‑II expression and the LC3B‑II/LC3B‑I ratio compared with the negative control (P<0.01). The results of the present study revealed that miR‑204‑5p downregulated the expression of LC3B‑II to inhibit autophagy in DR. Therefore, miR‑204‑5p may be considered as a novel effective therapeutic target during the development of DR.
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1 

Santos LL, Lima FJC, Sousa-Rodrigues CF and Barbosa FT: Use of SGLT-2 inhibitors in the treatment of type 2 diabetes mellitus. Rev Assoc Med Bras (1992). 63:636–641. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Murchison AP, Hark L, Pizzi LT, Dai Y, Mayro EL, Storey PP, Leiby BE and Haller JA: Non-adherence to eye care in people with diabetes. BMJ Open Diabetes Res Care. 5:e0003332017. View Article : Google Scholar : PubMed/NCBI

3 

Leasher JL, Bourne RR, Flaxman SR, Jonas JB, Keeffe J, Naidoo N, Pesudovs K, Price H, White RA, Wong TY, et al: Erratum. Global estimates on the number of people blind or visually impaired by diabetic retinopathy: A meta-analysis from 1990–2010. Diabetes Care 2016;39:1643-1649. Diabetes Care. 39:20962016. View Article : Google Scholar : PubMed/NCBI

4 

Arroba AI, Campos-Caro A, Aguilar-Diosdado M and Valverde AM: IGF-1, inflammation and retinal degeneration: A close network. Front Aging Neurosci. 10:2032018. View Article : Google Scholar : PubMed/NCBI

5 

Hou L, Wei L, Zhu S, Wang J, Quan R, Li Z and Liu J: Avian metapneumovirus subgroup C induces autophagy through the ATF6 UPR pathway. Autophagy. 13:1709–1721. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Wang L, Feng D, Liu Y, Li S, Jiang L, Long Z and Wu Y: Autophagy plays a protective role in motor neuron degeneration following spinal cord ischemia/reperfusion-induced spastic paralysis. Am J Transl Res. 9:4261–4270. 2017.PubMed/NCBI

7 

Gao N, Wang H, Yin H and Yang Z: Angiotensin II induces calcium-mediated autophagy in podocytes through enhancing reactive oxygen species levels. Chem Biol Interact. 277:110–118. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Wang T, Zhang L, Hu J, Duan Y, Zhang M, Lin J, Man W, Pan X, Jiang Z, Zhang G, et al: Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement. J Mol Cell Cardiol. 98:108–116. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Dehdashtian E, Mehrzadi S, Yousefi B, Hosseinzadeh A, Reiter RJ, Safa M, Ghaznavi H and Naseripour M: Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress. Life Sci. 193:20–33. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Lopes de Faria JM, Duarte DA, Montemurro C, Papadimitriou A, Consonni SR and Lopes de Faria JB: Defective autophagy in diabetic retinopathy. Invest Ophthalmol Vis Sci. 57:4356–4366. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Alizadeh S, Mazloom H, Sadeghi A, Emamgholipour S, Golestani A, Noorbakhsh F, Khoshniatnikoo M and Meshkani R: Evidence for the link between defective autophagy and inflammation in peripheral blood mononuclear cells of type 2 diabetic patients. J Physiol Biochem. 74:369–379. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Chandra S, Vimal D, Sharma D, Rai V, Gupta SC and Chowdhuri DK: Role of miRNAs in development and disease: Lessons learnt from small organisms. Life Sci. 185:8–14. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Nadeem A, Ashraf MR, Javed M, Hussain T, Tariq MS and Babar ME: Review-microRNAs: A new paradigm towards mechanistic insight of diseases. Pak J Pharm Sci. 31:2017–2026. 2018.PubMed/NCBI

15 

Gong Q, Xie J, Liu Y, Li Y and Su G: Differentially expressed micrornas in the development of early diabetic retinopathy. J Diabetes Res. 2017:47279422017. View Article : Google Scholar : PubMed/NCBI

16 

Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RVS, Yang Y, Moran E and Ma JX: Pathogenic role of microRNA-21 in diabetic retinopathy through downregulation of PPARα. Diabetes. 66:1671–1682. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Haque R, Iuvone PM, He L, Choi KSC, Ngo A, Gokhale S, Aseem M and Park D: The MicroRNA-21 signaling pathway is involved in prorenin receptor (PRR)-induced VEGF expression in ARPE-19 cells under a hyperglycemic condition. Mol Vis. 23:251–262. 2017.PubMed/NCBI

18 

Gomaa AR, Elsayed ET and Moftah RF: MicroRNA-200b expression in the vitreous humor of patients with proliferative diabetic retinopathy. Ophthalmic Res. 58:168–175. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Wu JH, Gao Y, Ren AJ, Zhao SH, Zhong M, Peng YJ, Shen W, Jing M and Liu L: Altered microRNA expression profiles in retinas with diabetic retinopathy. Ophthalmic Res. 47:195–201. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Gao J, Wang Y, Zhao X, Chen P and Xie L: MicroRNA-204-5p-mediated regulation of SIRT1 contributes to the delay of epithelial cell cycle traversal in diabetic corneas. Invest Ophthalmol Vis Sci. 56:1493–1504. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Nathan DM, Buse JB, Davidson MB, Heine RJ, Holman RR, Sherwin R and Zinman B: Management of hyperglycaemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American diabetes association and the european association for the study of diabetes. Diab Tologia. 49:1711–1721. 2006. View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Rubsam A, Parikh S and Fort PE: Role of Inflammation in diabetic retinopathy. Int J Mol Sci. 19(pii): E9422018. View Article : Google Scholar : PubMed/NCBI

24 

Kaneko H and Terasaki H: Biological involvement of MicroRNAs in proliferative vitreoretinopathy. Transl Vis Sci Technol. 6:52017. View Article : Google Scholar : PubMed/NCBI

25 

Wu D, Pan H, Zhou Y, Zhang Z, Qu P, Zhou J and Wang W: Upregulation of microRNA-204 inhibits cell proliferation, migration and invasion in human renal cell carcinoma cells by downregulating SOX4. Mol Med Rep. 12:7059–7064. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Liu J and Li Y: Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERalpha reducing AKT/mTOR pathway. Biochem Biophys Res Commun. 467:242–247. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Lorenzon L, Cippitelli C, Avantifiori R, Uccini S, French D, Torrisi MR, Ranieri D, Mercantini P, Canu V, Blandino G and Cavallini M: Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system. J Surg Oncol. 116:184–194. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Palkina N, Komina A, Aksenenko M, Moshev A, Savchenko A and Ruksha T: miR-204-5p and miR-3065-5p exert antitumor effects on melanoma cells. Oncol Lett. 15:8269–8280. 2018.PubMed/NCBI

29 

Gao W, Wu Y, He X, Zhang C, Zhu M, Chen B, Liu Q, Qu X, Li W, Wen S and Wang B: MicroRNA-204-5p inhibits invasion and metastasis of laryngeal squamous cell carcinoma by suppressing forkhead box C1. J Cancer. 8:2356–2368. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Li H, Wang J, Liu X and Cheng Q: MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R. Biochem Cell Biol. 2018.(Epub ahead of print). View Article : Google Scholar

31 

Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature. 451:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Volpe CMO, Villar-Delfino PH, Dos Anjos PMF and Nogueira-Machado JA: Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis. 9:1192018. View Article : Google Scholar : PubMed/NCBI

33 

Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Yoshii SR and Mizushima N: Monitoring and measuring autophagy. Int J Mol Sci. 18(pii): E18652017. View Article : Google Scholar : PubMed/NCBI

35 

Li XC, Hu QK, Chen L, Liu SY, Su S, Tao H, Zhang LN, Sun T and He LJ: HSPB8 promotes the fusion of autophagosome and lysosome during autophagy in diabetic neurons. Int J Med Sci. 14:1335–1341. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Cai X, Li J, Wang M, She M, Tang Y, Li H and Hui H: GLP-1 treatment improves diabetic retinopathy by alleviating autophagy through GLP-1R-ERK1/2-HDAC6 signaling pathway. Int J Med Sci. 14:1203–1212. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Kobayashi S, Xu X, Chen K and Liang Q: Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury. Autophagy. 8:577–592. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, et al: VEGF secreted by hypoxic muller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy. Diabetes. 62:3863–3873. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Nishijima K, Ng YS, Zhong L, Bradley J, Schubert W, Jo N, Akita J, Samuelsson SJ, Robinson GS, Adamis AP and Shima DT: Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol. 171:53–67. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Gilbert RE, Vranes D, Berka JL, Kelly DJ, Cox A, Wu LL, Stacker SA and Cooper ME: Vascular endothelial growth factor and its receptors in control and diabetic rat eyes. Lab Invest. 78:1017–1027. 1998.PubMed/NCBI

41 

Bai Y, Ma JX, Guo J, Wang J, Zhu M, Chen Y and Le YZ: Muller cell-derived VEGF is a significant contributor to retinal neovascularization. J Pathol. 219:446–454. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mao XB, Cheng YH and Xu YY: miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3. Exp Ther Med 17: 2945-2952, 2019.
APA
Mao, X., Cheng, Y., & Xu, Y. (2019). miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3. Experimental and Therapeutic Medicine, 17, 2945-2952. https://doi.org/10.3892/etm.2019.7327
MLA
Mao, X., Cheng, Y., Xu, Y."miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3". Experimental and Therapeutic Medicine 17.4 (2019): 2945-2952.
Chicago
Mao, X., Cheng, Y., Xu, Y."miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2945-2952. https://doi.org/10.3892/etm.2019.7327
Copy and paste a formatted citation
x
Spandidos Publications style
Mao XB, Cheng YH and Xu YY: miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3. Exp Ther Med 17: 2945-2952, 2019.
APA
Mao, X., Cheng, Y., & Xu, Y. (2019). miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3. Experimental and Therapeutic Medicine, 17, 2945-2952. https://doi.org/10.3892/etm.2019.7327
MLA
Mao, X., Cheng, Y., Xu, Y."miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3". Experimental and Therapeutic Medicine 17.4 (2019): 2945-2952.
Chicago
Mao, X., Cheng, Y., Xu, Y."miR‑204‑5p promotes diabetic retinopathy development via downregulation of microtubule‑associated protein 1 light chain 3". Experimental and Therapeutic Medicine 17, no. 4 (2019): 2945-2952. https://doi.org/10.3892/etm.2019.7327
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