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Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients

  • Authors:
    • Yingzhe Wu
    • Xiangli Tang
    • Weifang Shao
    • Yuezhong Lu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Changxing People's Hospital, Huzhou, Zhejiang 313100, P.R. China, Department of Clinical Laboratory, Changxing People's Hospital, Huzhou, Zhejiang 313100, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4441-4446
    |
    Published online on: April 12, 2019
       https://doi.org/10.3892/etm.2019.7484
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Abstract

Effect of CT manifestations of cholesteatomatous otitis media on matrix metalloproteinase‑2 (MMP‑2), matrix metalloproteinase‑9 (MMP‑9) and interleukin‑6 (IL‑6) in the serum of patients was investigated. A total of 176 patients with cholesteatomatous otitis media were enrolled as the study group and 181 patients with simple otitis media were enrolled as the control group. Patients were admitted to the Changxing People's Hospital from January 2010 to December 2016. The patients in the study group were classified according to the 64‑row spiral CT diagnosis. The expression levels of MMP‑2, MMP‑9 and IL‑6 in the serum of the selected patients were detected by ELISA. MMP‑2, MMP‑9 and IL‑6 expression levels in the study group were higher than those in the control group (P<0.05). MMP‑2, MMP‑9 and IL‑6 expression levels in the serum of the patients with injured ossicular chain were significantly higher than those in the serum of patients with injured malleus or incus (P<0.05), and significantly higher than those in the serum of patients with intact ossicular chain (P<0.05). The levels of MMP‑2, MMP‑9 and IL‑6 in the serum of the patients whose malleus or incus was injured were higher than those in the serum of the patients with intact ossicular chain (P<0.05). There was an obvious positive correlation between the injury degree of different sclerotins in CT manifestations of the patients in the study group and MMP‑2, MMP‑9, and IL‑6 (P<0.05). The high expression levels of MMP‑2, MMP‑9 and IL‑6 in the serum of patients with cholesteatomatous otitis media were positively correlated with the injury degree of ossicle, which may be a sign of poor prognosis of cholesteatomatous otitis media.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Tang X, Shao W and Lu Y: Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients . Exp Ther Med 17: 4441-4446, 2019.
APA
Wu, Y., Tang, X., Shao, W., & Lu, Y. (2019). Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients . Experimental and Therapeutic Medicine, 17, 4441-4446. https://doi.org/10.3892/etm.2019.7484
MLA
Wu, Y., Tang, X., Shao, W., Lu, Y."Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients ". Experimental and Therapeutic Medicine 17.6 (2019): 4441-4446.
Chicago
Wu, Y., Tang, X., Shao, W., Lu, Y."Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients ". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4441-4446. https://doi.org/10.3892/etm.2019.7484
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Tang X, Shao W and Lu Y: Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients . Exp Ther Med 17: 4441-4446, 2019.
APA
Wu, Y., Tang, X., Shao, W., & Lu, Y. (2019). Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients . Experimental and Therapeutic Medicine, 17, 4441-4446. https://doi.org/10.3892/etm.2019.7484
MLA
Wu, Y., Tang, X., Shao, W., Lu, Y."Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients ". Experimental and Therapeutic Medicine 17.6 (2019): 4441-4446.
Chicago
Wu, Y., Tang, X., Shao, W., Lu, Y."Effect of CT manifestations of cholesteatoma on MMP‑2, MMP‑9 and IL‑6 in the serum of patients ". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4441-4446. https://doi.org/10.3892/etm.2019.7484
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