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Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis

  • Authors:
    • Xin Mou
    • Di Yi Zhou
    • Ying Hui Liu
    • Kaiyuan Liu
    • Danyang Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Zhejiang Integrated and Western Medicine Hospital, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Mou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4617-4627
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    Published online on: April 23, 2019
       https://doi.org/10.3892/etm.2019.7524
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Abstract

The aim of the present study was to identify genes under the effect of transforming growth factor‑β (TGF‑β1), high glucose (HG) and glucosamine (GlcN) in MES‑13 mesangial cells and elucidate the molecular mechanisms of diabetic nephropathy (DN). The gene expression datasets GSE2557 and GSE2558 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were independently screened using the GEO2R online tool. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the Database for Annotation, Visualization, and Integrated Discovery. The protein‑protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes and Cytoscape software. The hub genes were identified by the NetworkAnalyzer plugin. Overlapping genes were subjected to molecular docking analysis using SystemsDock. A total of 202 upregulated and 158 downregulated DEGs from the HG‑treated groups, 138 upregulated and 103 downregulated DEGs from the GlcN‑treated groups, and 81 upregulated and 44 downregulated DEGs from the TGF‑β1‑treated groups were identified. The majority of the DEGs were independently enriched in ‘nucleosome assembly’, ‘chromatin silencing’ and ‘xenobiotic glucuronidation’. In addition, KEGG pathways were significantly enriched in ‘systemic lupus erythematosus’, ‘protein processing in endoplasmic reticulum’ and ‘aldarate metabolism pathway’, and ‘TNF signaling pathway’ intersected in the TGF‑β1‑treated and HG‑treated groups. In total, eight hub genes, Jun, prostaglandin‑endoperoxide synthase 2 (Ptgs2), fibronectin 1 (Fn1), cyclin‑dependent kinase (Cdk)2, Fos, heat shock protein family A (Hsp70) member 5 (Hspa5), Hsp90b1 and homo sapiens hypoxia upregulated 1 (Hyou1), and three overlapping genes, Ras homolog gene family, member B (RHOB), complement factor H (CFH) and Krüppel‑like factor 15 (KLF15), were selected. Valsartan with RHOB, and fosinopril with CFH and KLF15 had preferential binding activity. In conclusion, Jun, Ptgs2, Fn1, Cdk2, Fos, Hspa5, Hsp90b1, Hyou1, RHOB, CFH and KLF15 may be potential therapeutic targets for mesangial cells associated with DN, which may provide insight into DN treatment strategies.
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View References

1 

Sathibabu Uddandrao VV, Brahmanaidu P, Ravindarnaik R, Suresh P, Vadivukkarasi S and Saravanan G: Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic rats. Eur J Nutr. July 30–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

2 

Wagnew F, Eshetie S, Kibret GD, Zegeye A, Dessie G, Mulugeta H and Alemu A: Diabetic nephropathy and hypertension in diabetes patients of sub-Saharan countries: A systematic review and meta-analysis. BMC Res Notes. 11:5652018. View Article : Google Scholar : PubMed/NCBI

3 

Mafi A, Aghadavod E, Mirhosseini N, Mobini M and Asemi Z: The effects of expression of different microRNAs on insulin secretion and diabetic nephropathy progression. J Cell Physiol. 234:42–50. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Song X, Gong M, Chen Y, Liu H and Zhang J: Nine hub genes as the potential indicator for the clinical outcome of diabetic nephropathy. J Cell Physiol. 234:1461–1468. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Liu P, Peng L, Zhang H, Tang PM, Zhao T, Yan M, Zhao H, Huang X, Lan H and Li P: Tangshen formula attenuates diabetic nephropathy by promoting ABCA1-mediated renal cholesterol efflux in db/db Mice. Front Physiol. 9:3432018. View Article : Google Scholar : PubMed/NCBI

6 

Wu T, Li Q, Wu T and Liu HY: Identification of biological targets of therapeutic intervention for diabetic nephropathy with bioinformatics approach. Exp Clin Endocrinol Diabetes. 122:587–591. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Ziyadeh FN and Wolf G: Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr Diabetes Rev. 4:39–45. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Wu J, Liu J, Ding Y, Zhu M, Lu K, Zhou J, Xie X, Xu Y, Shen X, Chen Y, et al: MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. Biochem Biophys Res Commun. 503:977–983. 2018. View Article : Google Scholar : PubMed/NCBI

9 

He F, Peng F, Xia X, Zhao C, Luo Q, Guan W, Li Z, Yu X and Huang F: MiR-135a promotes renal fibrosis in diabetic nephropathy by regulating TRPC1. Diabetologia. 57:1726–1736. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Putta S, Lanting L, Sun G, Lawson G, Kato M and Natarajan R: Inhibiting MicroRNA-192 Ameliorates renal fibrosis in diabetic nephropathy. J Am Soc Nephrol. 23:458–469. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Chen Y, Qiao F, Zhao Y, Wang Y and Liu G: HMGB1 is activated in type 2 diabetes mellitus patients and in mesangial cells in response to high glucose. Int J Clin Exp Pathol. 8:6683–6691. 2015.PubMed/NCBI

12 

Seo E, Kang H, Oh YS and Jun HS: Psoralea corylifolia L. Seed extract attenuates diabetic nephropathy by inhibiting renal fibrosis and apoptosis in streptozotocin-induced diabetic mice. Nutrients. 9(pii): E8282017. View Article : Google Scholar : PubMed/NCBI

13 

Braga Gomes K, Fontana Rodrigues K and Fernandes AP: The role of transforming growth factor-beta in diabetic nephropathy. Int J Med Genet. 2014:1–6. 2014. View Article : Google Scholar

14 

Hills CE and Squires PE: The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy. Cytokine Growth Factor Rev. 22:131–139. 2011.PubMed/NCBI

15 

Cheng DW, Jiang Y, Shalev A, Kowluru R, Crook ED and Singh LP: An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells. Arch Physiol Biochem. 112:189–218. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Chen Y, Teng L, Liu W, Cao Y, Ding D, Wang W, Chen H, Li C and An R: Identification of biological targets of therapeutic intervention for clear cell renal cell carcinoma based on bioinformatics approach. Cancer Cell Int. 16:162016. View Article : Google Scholar : PubMed/NCBI

17 

Tang Y, Zhang Z, Tang Y, Chen X and Zhou J: Identification of potential target genes in pancreatic ductal adenocarcinoma by bioinformatics analysis. Oncol Lett. 16:2453–2461. 2018.PubMed/NCBI

18 

Kanehisa M, Goto S, Sato Y, Furumichi M and Tanabe M: KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 40 (Database Issue). D109–D114. 2012. View Article : Google Scholar

19 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, et al: DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Res. 46:D1074–D1082. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Hsin KY, Matsuoka Y, Asai Y, Kamiyoshi K, Watanabe T, Kawaoka Y and Kitano H: SystemsDock: A web server for network pharmacology-based prediction and analysis. Nucleic Acids Res. 44:W507–W513. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Hsin KY, Ghosh S and Kitano H: Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology. PLoS One. 8:e839222013. View Article : Google Scholar : PubMed/NCBI

23 

Ma J, Zhang L, Hao J, Li N, Tang J and Hao L: Up-regulation of microRNA-93 inhibits TGF-β1-induced EMT and renal fibrogenesis by down-regulation of Orai1. J Pharmacol Sci. 136:218–227. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Deshpande S, Abdollahi M, Wang M, Lanting L, Kato M and Natarajan R: Reduced autophagy by a microRNA-mediated signaling cascade in diabetes-induced renal glomerular hypertrophy. Sci Rep. 8:69542018. View Article : Google Scholar : PubMed/NCBI

25 

Song KH, Park J, Park JH, Natarajan R and Ha H: Fractalkine and its receptor mediate extracellular matrix accumulation in diabetic nephropathy in mice. Diabetologia. 56:1661–1669. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Kanwar YS, Sun L, Xie P, Liu FY and Chen S: A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol. 6:395–423. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Reidy K, Kang HM, Hostetter T and Susztak K: Molecular mechanisms of diabetic kidney disease. J Clin Invest. 124:2333–2340. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Meng XM, Nikolic-Paterson DJ and Lan HY: TGF-β: The master regulator of fibrosis. Nat Rev Nephrol. 12:325–328. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Lim AK and Tesch GH: Inflammation in diabetic nephropathy. Mediators Inflamm. 2012:1461542012. View Article : Google Scholar : PubMed/NCBI

30 

Lan HY: Transforming growth factor-β/Smad signalling in diabetic nephropathy. Clin Exp Pharmacol Physiol. 39:731–738. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Xu L, Shen P, Bi Y, Chen J, Xiao Z, Zhang X and Wang Z: Danshen injection ameliorates STZ-induced diabetic nephropathy in association with suppression of oxidative stress, pro-inflammatory factors and fibrosis. Int Immunopharmacol. 38:385–394. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Jochum W, Passegué E and Wagner EF: AP-1 in mouse development and tumorigenesis. Oncogene. 20:2401–2412. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Weigert C, Sauer U, Brodbeck K, Pfeiffer A, Häring HU and Schleicher ED: AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells. J Am Soc Nephrol. 11:2007–2016. 2000.PubMed/NCBI

34 

Gao P, Wei Y, Zhang Z, Zeng W, Sun D, Liu D, Hou B, Zhang C, Zhang N, Li H and Li L: Synergistic effects of c-Jun and SP1 in the promotion of TGFβ1-mediated diabetic nephropathy progression. Exp Mol Pathol. 100:441–450. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Wang X, Yao B, Wang Y, Fan X, Wang S, Niu A, Yang H, Fogo A, Zhang MZ and Harris RC: Macrophage Cyclooxygenase-2 protects against development of diabetic nephropathy. Diabetes. 66:494–504. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Watanabe Y, Yamaguchi T, Ishihara N, Nakamura S, Tanaka S, Oka R, Imamura H, Sato Y, Ban N, Kawana H, et al: 7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy. Prostaglandins Other Lipid Mediat. 134:16–23. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, McKanna JA and Harris RC: Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension1. Kidney Int. 62:929–939. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Cheng H, Fan X, Moeckel GW and Harris RC: Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. J Am Soc Nephrol. 22:1240–1251. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Ma X, Lu C, Lv C and Wang Q: The expression of miR-192 and its significance in diabetic nephropathy patients with different urine albumin creatinine ratio. J Diabetes Res. 2016:67894022016. View Article : Google Scholar : PubMed/NCBI

40 

Tian RQ, Wang XH, Hou LJ, Jia WH, Yang Q, Li YX, Liu M, Li X and Tang H: MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigene. J Biol Chem. 286:25556–25563. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Saurus P, Kuusela S, Dumont V, Lehtonen E, Fogarty CL, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH and Lehtonen S: Cyclin-dependent kinase 2 protects podocytes from apoptosis. Sci Rep. 6:216642016. View Article : Google Scholar : PubMed/NCBI

42 

Huang K, Huang J, Chen C, Hao J, Wang S, Huang J, Liu P and Huang H: AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. Cell Signal. 26:629–638. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Chen S, Mukherjee S, Chakraborty C and Chakrabarti S: High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1. Am J Physiol Cell Physiol. 284:C263–C272. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Haneda M, Koya D, Isono M and Kikkawa R: Overview of glucose signaling in mesangial cells in diabetic nephropathy. J Am Soc Nephrol. 14:1374–1382. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Cao AL, Wang L, Chen X, Wang YM, Guo HJ, Chu S, Liu C, Zhang XM and Peng W: Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy. Lab Invest. 96:610–622. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Chen Y, Gui D, Chen J, He D, Luo Y and Wang N: Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats. Cell Physiol Biochem. 33:1975–1987. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Lindenmeyer MT, Rastaldi MP, Ikehata M, Neusser MA, Kretzler M, Cohen CD and Schlöndorff D: Proteinuria and hyperglycemia induce endoplasmic reticulum stress. J Am Soc Nephrol. 19:2225–2236. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Chen J, Hou XF, Wang G, Zhong QX, Liu Y, Qiu HH, Yang N, Gu JF, Wang CF, Zhang L, et al: Terpene glycoside component from Moutan Cortex ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-related inflammatory responses. J Ethnopharmacol. 193:433–444. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Eletto D, Dersh D and Argon Y: GRP94 in ER quality control and stress responses. Semin Cell Dev Biol. 21:479–485. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Huang M and Prendergast GC: RhoB in cancer suppression. Histol Histopathol. 21:213–218. 2006.PubMed/NCBI

51 

Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI and Benjamin LE: RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. Am J Pathol. 178:245–252. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Mehta G, Ferreira VP, Skerka C, Zipfel PF and Banda NK: New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol. 62:235–248. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Bonomo JA, Palmer ND, Hicks PJ, Lea JP, Okusa MD, Langefeld CD, Bowden DW and Freedman BI: Complement factor H gene associations with end-stage kidney disease in African Americans. Nephrol Dial Transplant. 29:1409–1414. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Mallipattu SK, Estrada CC and He JC: The critical role of Krüppel-like factors in kidney disease. Am J Physiol Renal Physiol. 312:F259–F265. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Guo Y, Pace J, Li Z, Ma'ayan A, Wang Z, Revelo MP, Chen E, Gu X, Attalah A, Yang Y, Estrada C, et al: Podocyte-specific induction of Krüppel-like factor 15 restores differentiation markers and attenuates kidney injury in proteinuric kidney disease. J Am Soc Nephrol. 29:2529–2545. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mou X, Zhou DY, Liu YH, Liu K and Zhou D: Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis. Exp Ther Med 17: 4617-4627, 2019.
APA
Mou, X., Zhou, D.Y., Liu, Y.H., Liu, K., & Zhou, D. (2019). Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis. Experimental and Therapeutic Medicine, 17, 4617-4627. https://doi.org/10.3892/etm.2019.7524
MLA
Mou, X., Zhou, D. Y., Liu, Y. H., Liu, K., Zhou, D."Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis". Experimental and Therapeutic Medicine 17.6 (2019): 4617-4627.
Chicago
Mou, X., Zhou, D. Y., Liu, Y. H., Liu, K., Zhou, D."Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4617-4627. https://doi.org/10.3892/etm.2019.7524
Copy and paste a formatted citation
x
Spandidos Publications style
Mou X, Zhou DY, Liu YH, Liu K and Zhou D: Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis. Exp Ther Med 17: 4617-4627, 2019.
APA
Mou, X., Zhou, D.Y., Liu, Y.H., Liu, K., & Zhou, D. (2019). Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis. Experimental and Therapeutic Medicine, 17, 4617-4627. https://doi.org/10.3892/etm.2019.7524
MLA
Mou, X., Zhou, D. Y., Liu, Y. H., Liu, K., Zhou, D."Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis". Experimental and Therapeutic Medicine 17.6 (2019): 4617-4627.
Chicago
Mou, X., Zhou, D. Y., Liu, Y. H., Liu, K., Zhou, D."Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4617-4627. https://doi.org/10.3892/etm.2019.7524
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