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Fetal microtia and FGFR2 polymorphism

  • Authors:
    • Ruilian Zhao
    • Peixia Du
    • Hongmei Sun
    • Li Yang
    • Pingzhen Lin
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Maternity and Child Health Care of Zaozhuang, Zaozhuang, Shandong 277100, P.R. China, Department of Obstetrics and Gynecology, Shanting People's Hospital of Zaozhuang, Zaozhuang, Shandong 277200, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 384-388
    |
    Published online on: May 10, 2019
       https://doi.org/10.3892/etm.2019.7568
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Abstract

Association of the single-nucleotide polymorphism (SNP) of rs3135718 site in fibroblast growth factor receptor 2 (FGFR2) gene with congenital microtia was investigated. A total of 193 patients with congenital microtia (observation group) and 150 normal and healthy fetuses (control group) treated in Maternity and Child Health Care of Zaozhuang from January 2010 to October 2017 were randomly selected. The gene and genotype of the rs3135718 site of FGFR2 gene SNP were detected via quantitative polymerase chain reaction (qPCR). The association between rs3135718 site SNP and congenital microtia was analyzed. No statistically significant difference in the prevalence of congenital microtia was observed in the rs3135718 genotype (AG) between the observation and control group (P>0.05). The GG and G genotypes in rs3135718 were closely related to fetal microtia (P<0.05). Results revealed that the rs3135718-GG mutation was more correlated with the risk of microtia in male (P<0.05), but not correlated with the risk of microtia in female (P>0.05). Moreover, there was a statistically significant difference in the distribution of rs3135718-G allele frequency in male between the two groups (P<0.05). The rs3135718-G gene in FGFR2 has a certain association with the incidence of congenital microtia with high prevalence and risk.
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1 

Fischer S, Hirsch T, Hirche C, Kiefer J, Kueckelhaus M, Germann G and Reichenberger MA: Surgical treatment of primary gynecomastia in children and adolescents. Pediatr Surg Int. 30:641–647. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Yin L, Du X, Li C, Xu X, Chen Z, Su N, Zhao L, Qi H, Li F, Xue J, et al: A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis. Bone. 42:631–643. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Wang Y, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai J, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, et al: Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development. 132:3537–3548. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Canfield MA, Langlois PH, Nguyen LM and Scheuerle AE: Epidemiologic features and clinical subgroups of anotia/microtia in Texas. Birth Defects Res A Clin Mol Teratol. 85:905–913. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Suutarla S, Rautio J, Ritvanen A, Ala-Mello S, Jero J and Klockars T: Microtia in Finland: Comparison of characteristics in different populations. Int J Pediatr Otorhinolaryngol. 71:1211–1217. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Forrester MB and Merz RD: Descriptive epidemiology of anotia and microtia, Hawaii, 1986–2002. Congenit Anom (Kyoto). 45:119–124. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Harris J, Källén B and Robert E: The epidemiology of anotia and microtia. J Med Genet. 33:809–813. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Bartel-Friedrich S: Congenital auricular malformations: Description of anomalies and syndromes. Facial Plast Surg. 31:567–580. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Artunduaga MA, Quintanilla-Dieck ML, Greenway S, Betensky R, Nicolau Y, Hamdan U, Jarrin P, Osorno G, Brent B, Eavey R, et al: A classic twin study of external ear malformations, including microtia. N Engl J Med. 361:1216–1218. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Luquetti DV, Heike CL, Hing AV, Cunningham ML and Cox TC: Microtia: Epidemiology and genetics. Am J Med Genet A 158A. 124–139. 2012. View Article : Google Scholar

12 

Guizar-Vázquez J, Arredondo-Vega F, Rostenberg I, Manzano C and Armendares S: Microtia and meatal atresia in mother and son. Clin Genet. 14:80–82. 1978. View Article : Google Scholar : PubMed/NCBI

13 

Zankl M and Zang KD: Inheritance of microtia and aural atresia in a family with five affected members. Clin Genet. 16:331–334. 1979. View Article : Google Scholar : PubMed/NCBI

14 

Orstavik KH, Medbø S and Mair IW: Right-sided microtia and conductive hearing loss with variable expressivity in three generations. Clin Genet. 38:117–120. 1990. View Article : Google Scholar : PubMed/NCBI

15 

Chafai Elalaoui S, Cherkaoui Jaouad I, Rifai L and Sefiani A: Autosomal dominant microtia. Eur J Med Genet. 53:100–103. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Konigsmark BW, Nager GT and Haskins HL: Recessive microtia, meatal atresia, and hearing loss. Report of a sibship. Arch Otolaryngol. 96:105–109. 1972. View Article : Google Scholar : PubMed/NCBI

17 

Schmid M, Schröder M, Langenbeck U, Opitz JM and Reynolds JF: Familial microtia, meatal atresia, and conductive deafness in three siblings. Am J Med Genet. 22:327–332. 1985. View Article : Google Scholar : PubMed/NCBI

18 

Strisciuglio P, Ballabio A and Parenti G: Microtia with meatal atresia and conductive deafness: Mild and severe manifestations within the same sibship. J Med Genet. 23:459–460. 1986. View Article : Google Scholar : PubMed/NCBI

19 

Ornitz DM and Marie PJ: FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev. 16:1446–1465. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Su N, Sun Q, Li C, Lu X, Qi H, Chen S, Yang J, Du X, Zhao L, He Q, et al: Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum Mol Genet. 19:1199–1210. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao R, Du P, Sun H, Yang L and Lin P: Fetal microtia and FGFR2 polymorphism. Exp Ther Med 18: 384-388, 2019.
APA
Zhao, R., Du, P., Sun, H., Yang, L., & Lin, P. (2019). Fetal microtia and FGFR2 polymorphism. Experimental and Therapeutic Medicine, 18, 384-388. https://doi.org/10.3892/etm.2019.7568
MLA
Zhao, R., Du, P., Sun, H., Yang, L., Lin, P."Fetal microtia and FGFR2 polymorphism". Experimental and Therapeutic Medicine 18.1 (2019): 384-388.
Chicago
Zhao, R., Du, P., Sun, H., Yang, L., Lin, P."Fetal microtia and FGFR2 polymorphism". Experimental and Therapeutic Medicine 18, no. 1 (2019): 384-388. https://doi.org/10.3892/etm.2019.7568
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao R, Du P, Sun H, Yang L and Lin P: Fetal microtia and FGFR2 polymorphism. Exp Ther Med 18: 384-388, 2019.
APA
Zhao, R., Du, P., Sun, H., Yang, L., & Lin, P. (2019). Fetal microtia and FGFR2 polymorphism. Experimental and Therapeutic Medicine, 18, 384-388. https://doi.org/10.3892/etm.2019.7568
MLA
Zhao, R., Du, P., Sun, H., Yang, L., Lin, P."Fetal microtia and FGFR2 polymorphism". Experimental and Therapeutic Medicine 18.1 (2019): 384-388.
Chicago
Zhao, R., Du, P., Sun, H., Yang, L., Lin, P."Fetal microtia and FGFR2 polymorphism". Experimental and Therapeutic Medicine 18, no. 1 (2019): 384-388. https://doi.org/10.3892/etm.2019.7568
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