Long‑term prognostic value of coronary computed tomography angiography for asymptomatic patients with CAD in type 2 diabetes mellitus

  • Authors:
    • Peigang Tian
    • Xiangyang Zheng
    • Mingzhi Li
    • Weiwei Li
    • Qingliang Niu
  • View Affiliations

  • Published online on: May 20, 2019     https://doi.org/10.3892/etm.2019.7593
  • Pages: 747-754
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Abstract

The present study was performed to investigate the prognostic value of coronary computed tomography angiography (CTA) results for asymptomatic patients with coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM). A total of 164 asymptomatic patients with T2DM were enrolled at Weifang Traditional Chinese Hospital (Weifang, China). Coronary plaques and stenosis severity were evaluated after CTA. Structures >1 mm2 adjacent to or within the coronary artery lumen that could be clearly separated from the vessel lumen, was scored as a coronary plaque. Stenosis of ≥50% was considered as being obstructive. CAD was defined as the presence of any coronary plaque or a coronary artery calcium (CAC) score of >0. A CAC score of 0 and no coronary plaques was considered to indicate the absence of CAD. A 5‑year follow‑up was performed to determine the impact of the CTA findings and various clinicopathological characteristics on the prognosis of all participants. The primary end‑point was any cardiac event. Event‑free survival curves were plotted using the Kaplan‑Meier method and compared using the log‑rank test. Based on the coronary CTA results, the patients were classified into 3 groups according to the extent of stenosis: Normal coronary arteries, obstructive CAD and non‑obstructive CAD. Significant differences in 5‑year event‑free survival were identified among the groups with normal coronary arteries, non‑obstructive CAD and obstructive CAD (P=0.026). Further analysis indicated that the event‑free survival rate of patients with 1‑vessel CAD was 94.11%, that of patients with 2‑vessel CAD was 73.68% and that associated with 3‑vessel CAD was 61.54%. Multivariate Cox regression analysis revealed that non‑obstructive as well as obstructive CAD diagnosed by coronary CTA are prognostic indicators for asymptomatic T2DM patients [hazard ratio (HR)=11.132, 95% confidence interval (CI): 1.857‑66.742, P=0.008; HR=7.792, 95% CI: 1.750‑34.698, P=0.007, respectively]. In conclusion, the present study suggests that coronary CTA may predict the prognosis of asymptomatic patients with T2DM.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tian P, Zheng X, Li M, Li W and Niu Q: Long‑term prognostic value of coronary computed tomography angiography for asymptomatic patients with CAD in type 2 diabetes mellitus. Exp Ther Med 18: 747-754, 2019
APA
Tian, P., Zheng, X., Li, M., Li, W., & Niu, Q. (2019). Long‑term prognostic value of coronary computed tomography angiography for asymptomatic patients with CAD in type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 18, 747-754. https://doi.org/10.3892/etm.2019.7593
MLA
Tian, P., Zheng, X., Li, M., Li, W., Niu, Q."Long‑term prognostic value of coronary computed tomography angiography for asymptomatic patients with CAD in type 2 diabetes mellitus". Experimental and Therapeutic Medicine 18.1 (2019): 747-754.
Chicago
Tian, P., Zheng, X., Li, M., Li, W., Niu, Q."Long‑term prognostic value of coronary computed tomography angiography for asymptomatic patients with CAD in type 2 diabetes mellitus". Experimental and Therapeutic Medicine 18, no. 1 (2019): 747-754. https://doi.org/10.3892/etm.2019.7593