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Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome

  • Authors:
    • Jiajun Xiang
    • Ping Wang
  • View Affiliations / Copyright

    Affiliations: Department of Paediatrics, Linyi Central Hospital, Linyi, Shandong 276400, P.R. China, Department of Operation, Linyi Central Hospital, Linyi, Shandong 276400, P.R. China
    Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 654-658
    |
    Published online on: May 24, 2019
       https://doi.org/10.3892/etm.2019.7615
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Abstract

Clinical efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome (NRDS) was investigated. One hundred child patients with NRDS in Linyi Central Hospital were collected according to the diagnostic criteria for RDS in the Pediatrics, and randomly divided into the treatment group (n=50) and the control group (n=50) based on different therapeutic methods. Patients in the control group were treated with basic treatment and high-dose ambroxol hydrochloride injection, while those in the treatment group were additionally administered with pulmonary surfactant Curosurf based on conventional therapy in the control group. The chest X-rays were collected before the treatment and at 12 h after the drug administration, the degree of respiratory distress in child patients was observed and evaluated via Silverman grading, and changes in blood gas indexes were recorded before treatment and at 2, 6 and 12 h after the drug administration. The chest X-ray grade, Silverman grade and blood gas analysis results had no differences between the two groups before the treatment (P>0.05). In the treatment group, partial pressure of oxygen (PaO2) and PH were increased and partial pressure of carbon dioxide (PaCO2) was decreased compared with those in the control group at 2, 6 and 12 h after the drug administration (P<0.05). At 12 h after the drug administration, chest X-ray grade and Silverman grade in both groups were improved, which were significantly superior in the treatment group to those in the control group (P<0.01). Moreover, the efficacy in the treatment group was remarkably better than that in the control group at 12 h after drug administration (P<0.01). Pulmonary surfactant combined with high-dose ambroxol hydrochloride has definite efficacy in the treatment of NRDS, which can significantly improve the pulmonary infection, respiratory distress and blood gas indexes of child patients.
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1 

Sweet D, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, Saugstad OD, Simeoni U, Speer CP and Halliday HL; European Association of Perinatal Medicine, : European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants--2013 update. Zhonghua Er Ke Za Zhi. 52:749–755. 2014.(In Chinese). PubMed/NCBI

2 

Zhou B, Zhai JF, Wu JB, Jin B and Zhang YY: Different ventilation modes combined with ambroxol in the treatment of respiratory distress syndrome in premature infants. Exp Ther Med. 13:629–633. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Rodriguez RJ: Management of respiratory distress syndrome: An update. Respir Care. 48:279–286; discussion 286–287. 2003.PubMed/NCBI

4 

Liszewski MC, Stanescu AL, Phillips GS and Lee EY: Respiratory distress in neonates: Underlying causes and current imaging assessment. Radiol Clin North Am. 55:629–644. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Tochie JN, Choukem SP, Langmia RN, Barla E and Koki-Ndombo P: Neonatal respiratory distress in a reference neonatal unit in Cameroon: An analysis of prevalence, predictors, etiologies and outcomes. Pan Afr Med J. 24:1522016. View Article : Google Scholar : PubMed/NCBI

6 

Tabit CE, Chung WB, Hamburg NM and Vita JA: Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications. Rev Endocr Metab Disord. 11:61–74. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Jobe AH: Lung maturational agents and surfactant treatments: Are they complementary in preterm infants? J Perinatol. 9:14–18. 1989.PubMed/NCBI

8 

Speer CP: Neonatal respiratory distress syndrome: An inflammatory disease? Neonatology. 99:316–319. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Rijal P and Shrestha M: Scenario of neonatal respiratory distress in tertiary hospital. J Nepal Health Res Counc. 16:131–135. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Gitaka J, Natecho A, Mwambeo HM, Gatungu DM, Githanga D and Abuya T: Evaluating quality neonatal care, call centre service, tele-health and community engagement in reducing newborn morbidity and mortality in Bungoma county, Kenya. BMC Health Serv Res. 18:4932018. View Article : Google Scholar : PubMed/NCBI

11 

Fan YZ and Wen ZL: Efficacy of different dosages of ambroxol hydrochloride in the prevention of neonatal respiratory distress syndrome. Zhongguo Dang Dai Er Ke Za Zhi. 11:771–772. 2009.(In Chinese). PubMed/NCBI

12 

Wu X, Li S, Zhang J, Zhang Y, Han L, Deng Q and Wan X: Meta-analysis of high doses of ambroxol treatment for acute lung injury/acute respiratory distress syndrome based on randomized controlled trials. J Clin Pharmacol. 54:1199–1206. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ketko AK and Donn SM: Surfactant-associated proteins: Structure, function and clinical implications. Curr Pediatr Rev. 10:162–167. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Gortner L, Schüller SS and Herting E: Review demonstrates that less invasive surfactant administration in preterm neonates leads to fewer complications. Acta Paediatr. 107:736–743. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Zhang C and Zhu X: Clinical effects of pulmonary surfactant in combination with nasal continuous positive airway pressure therapy on neonatal respiratory distress syndrome. Pak J Med Sci. 33:621–625. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Baranwal AK, Murthy AS and Singhi SC: High-dose oral ambroxol for early treatment of pulmonary acute respiratory distress syndrome: An exploratory, randomized, controlled pilot trial. J Trop Pediatr. 61:339–350. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Gonzalez Garay AG, Reveiz L, Velasco Hidalgo L and Solis Galicia C: Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome. Cochrane Database Syst Rev (10). CD0097082014.

18 

Zhang ZQ, Huang XM and Lu H: Ambroxol for the prevention of respiratory distress syndrome in preterm infants: A meta analysis. Zhongguo Dang Dai Er Ke Za Zhi. 12:858–863. 2010.(In Chinese). PubMed/NCBI

19 

Elsayed HF, Elkhaiouby MI, Elsharkawey SM and Elnemr MA: Evaluation of the role of postnatal ambroxol in the prevention and treatment of respiratory distress syndrome in preterm neonates. Sultan Qaboos Univ Med J. 6:41–46. 2006.PubMed/NCBI

20 

Carrera G, Liberatore A, Riboni G and Clementi M: Surfactant and ambroxol in the therapy of idiopathic respiratory syndrome in newborn infants. Minerva Pediatr. 43:723–730. 1991.(In Italian). PubMed/NCBI

21 

Marini A, Franzetti M, Gios G, Flauto U, Arosio A, Maccabruni M, Rondini G, Chirico G, Giancola A, Console V, et al: Ambroxol in the treatment of idiopathic respiratory distress syndrome. An interim report on a controlled double-blind multicenter study versus placebo. Respiration. 51 (Suppl 1):60–67. 1987. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiang J and Wang P: Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome. Exp Ther Med 18: 654-658, 2019.
APA
Xiang, J., & Wang, P. (2019). Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome. Experimental and Therapeutic Medicine, 18, 654-658. https://doi.org/10.3892/etm.2019.7615
MLA
Xiang, J., Wang, P."Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 18.1 (2019): 654-658.
Chicago
Xiang, J., Wang, P."Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 18, no. 1 (2019): 654-658. https://doi.org/10.3892/etm.2019.7615
Copy and paste a formatted citation
x
Spandidos Publications style
Xiang J and Wang P: Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome. Exp Ther Med 18: 654-658, 2019.
APA
Xiang, J., & Wang, P. (2019). Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome. Experimental and Therapeutic Medicine, 18, 654-658. https://doi.org/10.3892/etm.2019.7615
MLA
Xiang, J., Wang, P."Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 18.1 (2019): 654-658.
Chicago
Xiang, J., Wang, P."Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome". Experimental and Therapeutic Medicine 18, no. 1 (2019): 654-658. https://doi.org/10.3892/etm.2019.7615
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