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Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia

  • Authors:
    • Takumi Kawaguchi
    • Atsumasa Komori
    • Kunio Fujisaki
    • Shuhei Nishiguchi
    • Michio Kato
    • Hitoshi Takagi
    • Yasuhito Tanaka
    • Kazuo Notsumata
    • Eiji Mita
    • Hideyuki Nomura
    • Mitsushige Shibatoge
    • Koichi Takaguchi
    • Toshihiro Hattori
    • Michio Sata
    • Kazuhiko Koike
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Division of Gastroenterology, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Nagasaki 856‑8562, Japan, Kirishima Medical Center, Kirishima, Kagoshima 899‑5112, Japan, Division of Hepatobiliary and Pancreatic Disease, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, National Hospital Organization Minami Wakayama Medical Center, Tanabe, Wakayama 646‑8558, Japan, Department of Gastroenterology, National Hospital Organization, Takasaki General Center Hospital, Takasaki, Gunma 370‑0829, Japan, Liver Disease Center, Nagoya University Hospital, Nagoya, Aichi 467‑8602, Japan, Department of Internal Medicine, Fukuiken Saiseikai Hospital, Fukui 918‑8503, Japan, Department of Gastroenterology, National Hospital Organization Osaka National Hospital, Osaka 540‑0006, Japan, Center for Liver Disease, Shin‑kokura Hospital, Kitakyushu, Fukuoka 803‑8505, Japan, Department of Gastroenterology, Takamatsu Red‑Cross Hospital, Takamatsu, Kagawa 760‑0017, Japan, Department of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa 760‑8557, Japan, Novartis Pharma KK, Tokyo 105‑6333, Japan, Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Fukuoka 830‑0011, Japan, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑0033, Japan
    Copyright: © Kawaguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 596-604
    |
    Published online on: May 24, 2019
       https://doi.org/10.3892/etm.2019.7616
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Abstract

To investigate the efficacy of eltrombopag for the treatment of thrombocytopenia in patients with chronic hepatitis C, a phase II, single‑arm, open‑label study with a 9‑week pre‑antiviral phase was conducted, followed by a 48‑week antiviral phase and a 24‑week follow‑up phase. The proportion of patients who achieved a platelet count threshold, the proportion of patients who maintained a platelet count >50,000/µl, sustained virological response (SVR) rates and safety parameters were evaluated. Of the 45 enrolled patients (median age, 59 years; median platelet count, 63,000/µl; 98% with Child‑Pugh class A), 43 (96%) achieved the platelet count threshold during the pre‑antiviral phase. A total of 13 patients (29%) experienced ≥1 adverse event (AE), of which headache and vomiting were the most common, and 41 patients (mostly receiving eltrombopag 12.5 mg or 25 mg) entered the antiviral phase, of which 36 (88%) maintained the platelet count threshold; no patient platelet count decreased below 25,000/µl. Nine patients (22%) achieved an SVR at the 24‑week follow‑up. Grade ≥3 AEs occurred in 25 patients (61%). A total of 8 serious AEs occurred in five patients (12%). No mortality, thromboembolic events (TEEs), or cataract progression were reported. Eltrombopag increased the platelet count in chronic hepatitis C virus‑infected patients with cirrhosis and thrombocytopenia and enabled them to initiate and complete interferon‑based antiviral therapy (NCT01636778; first submitted: July 05, 2012).
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Copy and paste a formatted citation
Spandidos Publications style
Kawaguchi T, Komori A, Fujisaki K, Nishiguchi S, Kato M, Takagi H, Tanaka Y, Notsumata K, Mita E, Nomura H, Nomura H, et al: Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia. Exp Ther Med 18: 596-604, 2019.
APA
Kawaguchi, T., Komori, A., Fujisaki, K., Nishiguchi, S., Kato, M., Takagi, H. ... Koike, K. (2019). Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia. Experimental and Therapeutic Medicine, 18, 596-604. https://doi.org/10.3892/etm.2019.7616
MLA
Kawaguchi, T., Komori, A., Fujisaki, K., Nishiguchi, S., Kato, M., Takagi, H., Tanaka, Y., Notsumata, K., Mita, E., Nomura, H., Shibatoge, M., Takaguchi, K., Hattori, T., Sata, M., Koike, K."Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia". Experimental and Therapeutic Medicine 18.1 (2019): 596-604.
Chicago
Kawaguchi, T., Komori, A., Fujisaki, K., Nishiguchi, S., Kato, M., Takagi, H., Tanaka, Y., Notsumata, K., Mita, E., Nomura, H., Shibatoge, M., Takaguchi, K., Hattori, T., Sata, M., Koike, K."Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia". Experimental and Therapeutic Medicine 18, no. 1 (2019): 596-604. https://doi.org/10.3892/etm.2019.7616
Copy and paste a formatted citation
x
Spandidos Publications style
Kawaguchi T, Komori A, Fujisaki K, Nishiguchi S, Kato M, Takagi H, Tanaka Y, Notsumata K, Mita E, Nomura H, Nomura H, et al: Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia. Exp Ther Med 18: 596-604, 2019.
APA
Kawaguchi, T., Komori, A., Fujisaki, K., Nishiguchi, S., Kato, M., Takagi, H. ... Koike, K. (2019). Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia. Experimental and Therapeutic Medicine, 18, 596-604. https://doi.org/10.3892/etm.2019.7616
MLA
Kawaguchi, T., Komori, A., Fujisaki, K., Nishiguchi, S., Kato, M., Takagi, H., Tanaka, Y., Notsumata, K., Mita, E., Nomura, H., Shibatoge, M., Takaguchi, K., Hattori, T., Sata, M., Koike, K."Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia". Experimental and Therapeutic Medicine 18.1 (2019): 596-604.
Chicago
Kawaguchi, T., Komori, A., Fujisaki, K., Nishiguchi, S., Kato, M., Takagi, H., Tanaka, Y., Notsumata, K., Mita, E., Nomura, H., Shibatoge, M., Takaguchi, K., Hattori, T., Sata, M., Koike, K."Eltrombopag enables initiation and completion of pegylated interferon/ribavirin therapy in Japanese HCV‑infected patients with chronic liver disease and thrombocytopenia". Experimental and Therapeutic Medicine 18, no. 1 (2019): 596-604. https://doi.org/10.3892/etm.2019.7616
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