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MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin

  • Authors:
    • Wei Zhu
    • Jia‑Li Long
    • Yu‑Ting Yin
    • Hai‑Na Guo
    • En‑Ping Jiang
    • Yu‑Ling Li
    • Qing‑Lian He
    • Chao Zeng
    • Yan‑Qin Sun
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China, Department of Pathology, Dongguan Maternal and Child Health Hospital, Dongguan, Guangdong 523002, P.R. China, Department of Pathology, Dongguan Hospital of Southern Medical University, Dongguan, Guangdong 523059, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2459-2466
    |
    Published online on: July 30, 2019
       https://doi.org/10.3892/etm.2019.7826
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Abstract

MicroRNAs (miRNAs/miRs) are small non‑coding RNAs that serve a post‑transcriptional regulatory role in eukaryotes. Previous studies have demonstrated that the expression of miR‑34a in colorectal cancer (CRC) tissues is decreased compared with that in normal colorectal tissues. However, the role of miR‑34a in the invasion and metastasis of CRC remains unclear. In the present study, the levels of miR‑34a expression were measured in various CRC cell lines. The cells were transfected with miR‑34a mimics or inhibitors in order to assess the proliferation rate, and the colony forming, invasive and migratory abilities. Furthermore, the protein expression levels of vimentin and early growth response protein 1 (EGR1) were examined by western blot analysis. The results revealed that the expression of miR‑34a was low in SW620, RKO, LoVo and Caco‑2 cell lines and high in the SW480 and SW1116 cell lines. The migration, invasion and proliferation levels of SW480 cells were facilitated by decreasing the expression of miR‑34a. Transient transfection with miR‑34a mimics in SW620 cells caused a notable decrease in cell migration, invasion and proliferation levels compared with the control group, and a downregulation of vimentin and upregulation of EGR1 protein expression. The present study demonstrated that miR‑34a was deregulated in a highly invasive CRC cell lines, and that it may attenuate the migratory, invasive and proliferative capabilities of CRC cells by enhancing the expression of EGR1 and inhibiting that of vimentin. The results of the present study represent important progress towards understanding the mechanisms of CRC recurrence and metastasis.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Ung L, Lam AK, Morris DL and Chua TC: Tissue-based biomarkers predicting outcomes in metastatic colorectal cancer: A review. Clin Transl Oncol. 16:425–435. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE and Bushell M: Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation. Science. 340:82–85. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Lin S and Gregory RI: MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 15:321–333. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Zhu J, Zou Z, Nie P, Kou X, Wu B, Wang S, Song Z and He J: Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression. Cell Death Dis. 7:e24542016. View Article : Google Scholar : PubMed/NCBI

10 

Ao X, Nie P, Wu B, Xu W, Zhang T, Wang S, Chang H and Zou Z: Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3. Cell Death Dis. 7:e24632016. View Article : Google Scholar : PubMed/NCBI

11 

Tazawa H, Tsuchiya N, Izumiya M and Nakagama H: Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA. 104:15472–15477. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Rokavec M, Li H, Jiang L and Hermeking H: The p53/miR-34 axis in development and disease. J Mol Cell Biol. 6:214–230. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Slabáková E, Culig Z, Remšík J and Souček K: Alternative mechanisms of miR-34a regulation in cancer. Cell Death Dis. 8:e31002017. View Article : Google Scholar : PubMed/NCBI

14 

Zhang X, Ai F, Li X, Tian L, Wang X, Shen S and Liu F: MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling. Oncol Lett. 14:2325–2333. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wu J, Wu G, Lv L, Ren YF, Zhang XJ, Xue YF, Li G, Lu X, Sun Z and Tang KF: MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis. 33:519–528. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Li L, Yuan L, Luo J, Gao J, Guo J and Xie X: MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1. Clin Exp Med. 13:109–117. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Franchina T, Amodeo V, Bronte G, Savio G, Ricciardi GR, Picciotto M, Russo A, Giordano A and Adamo V: Circulating miR-22, miR-24 and miR-34a as novel predictive biomarkers to pemetrexed-based chemotherapy in advanced non-small cell lung cancer. J Cell Physiol. 229:97–99. 2014.PubMed/NCBI

18 

Cao W, Yang W, Fan R, Li H, Jiang J, Geng M, Jin Y and Wu Y: miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway. Tumour Biol. 35:1287–1295. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Nugent M, Miller N and Kerin MJ: Circulating miR-34a levels are reduced in colorectal cancer. J Surg Oncol. 106:947–952. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Gao J, Li N, Dong Y, Li S, Xu L, Li X, Li Y, Li Z, Ng SS, Sung JJ, et al: miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. Oncogene. 34:4142–4152. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Liu C, Rangnekar VM, Adamson E and Mercola D: Suppression of growth and transformation and induction of apoptosis by EGR-1. Cancer Gene Ther. 5:3–28. 1998.PubMed/NCBI

23 

Calogero A, Arcella A, De Gregorio G, Porcellini A, Mercola D, Liu C, Lombari V, Zani M, Giannini G, Gagliardi FM, et al: The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas. Clin Cancer Res. 7:2788–2796. 2001.PubMed/NCBI

24 

Levin WJ, Press MF, Gaynor RB, Sukhatme VP, Boone TC, Reissmann PT, Figlin RA, Holmes EC, Souza LM and Slamon DJ: Expression patterns of immediate early transcription factors in human non-small cell lung cancer. The Lung Cancer Study Group. Oncogene. 11:1261–1269. 1995.PubMed/NCBI

25 

Ahmed MM: Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors. Curr Cancer Drug Targets. 4:43–52. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Baron V, Adamson ED, Calogero A, Ragona G and Mercola D: The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther. 13:115–124. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Virolle T, Adamson ED, Baron V, Birle D, Mercola D, Mustelin T and de Belle I: The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol. 3:1124–1128. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Krones-Herzig A, Adamson E and Mercola D: Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proc Natl Acad Sci USA. 100:3233–3238. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Kim SO, Kwon JI, Jeong YK, Kim GY, Kim ND and Choi YH: Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells. Biosci Biotechnol Biochem. 71:2169–2176. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Katsumoto T, Mitsushima A and Kurimura T: The role of the vimentin intermediate filaments in rat 3Y1 cells elucidated by immunoelectron microscopy and computer-graphic reconstruction. Biol Cell. 68:139–146. 1990. View Article : Google Scholar : PubMed/NCBI

31 

McInroy L and Maatta A: Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion. Biochem Biophys Res Commun. 360:109–114. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Bargagna-Mohan P, Hamza A, Kim YE, Khuan Abby Ho Y, Mor-Vaknin N, Wendschlag N, Liu J, Evans RM, Markovitz DM, Zhan CG, et al: The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 14:623–634. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Satelli A and Li S: Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci. 68:3033–3046. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Nieto MA: Epithelial plasticity: A common theme in embryonic and cancer cells. Science. 342:12348502013. View Article : Google Scholar : PubMed/NCBI

36 

Wrighton KH: Cell migration: EMT promotes contact inhibition of locomotion. Nat Rev Mol Cell Biol. 16:5182015. View Article : Google Scholar : PubMed/NCBI

37 

Xiao S, Liu L, Lu X, Long J, Zhou X and Fang M: The prognostic significance of bromodomain PHD-finger transcription factor in colorectal carcinoma and association with vimentin and E-cadherin. J Cancer Res Clin. 141:1465–1474. 2015. View Article : Google Scholar

38 

Toiyama Y, Yasuda H, Saigusa S, Tanaka K, Inoue Y, Goel A and Kusunoki M: Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer. Carcinogenesis. 34:2548–2557. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Rokavec M, Öner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, et al: IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest. 124:1853–1867. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu W, Long JL, Yin YT, Guo HN, Jiang EP, Li YL, He QL, Zeng C and Sun YQ: MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin. Exp Ther Med 18: 2459-2466, 2019.
APA
Zhu, W., Long, J., Yin, Y., Guo, H., Jiang, E., Li, Y. ... Sun, Y. (2019). MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin. Experimental and Therapeutic Medicine, 18, 2459-2466. https://doi.org/10.3892/etm.2019.7826
MLA
Zhu, W., Long, J., Yin, Y., Guo, H., Jiang, E., Li, Y., He, Q., Zeng, C., Sun, Y."MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin". Experimental and Therapeutic Medicine 18.4 (2019): 2459-2466.
Chicago
Zhu, W., Long, J., Yin, Y., Guo, H., Jiang, E., Li, Y., He, Q., Zeng, C., Sun, Y."MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2459-2466. https://doi.org/10.3892/etm.2019.7826
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu W, Long JL, Yin YT, Guo HN, Jiang EP, Li YL, He QL, Zeng C and Sun YQ: MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin. Exp Ther Med 18: 2459-2466, 2019.
APA
Zhu, W., Long, J., Yin, Y., Guo, H., Jiang, E., Li, Y. ... Sun, Y. (2019). MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin. Experimental and Therapeutic Medicine, 18, 2459-2466. https://doi.org/10.3892/etm.2019.7826
MLA
Zhu, W., Long, J., Yin, Y., Guo, H., Jiang, E., Li, Y., He, Q., Zeng, C., Sun, Y."MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin". Experimental and Therapeutic Medicine 18.4 (2019): 2459-2466.
Chicago
Zhu, W., Long, J., Yin, Y., Guo, H., Jiang, E., Li, Y., He, Q., Zeng, C., Sun, Y."MicroRNA‑34a suppresses the invasion and migration of colorectal cancer cells by enhancing EGR1 and inhibiting vimentin". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2459-2466. https://doi.org/10.3892/etm.2019.7826
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