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Article

The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients 

  • Authors:
    • Xiubao Zhao
    • Xu Li
    • Ying Ma
    • Yu Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Unit, Tianjin First Central Hospital, Tianjin 300192, P.R. China, Department of Clinical Laboratory, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, P.R. China
  • Pages: 2675-2680
    |
    Published online on: July 30, 2019
       https://doi.org/10.3892/etm.2019.7833
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Abstract

High levels of homocysteine (Hcy) is closely associated with the onset of cerebral infarction. The present study aimed to synthesize a novel Hcy probe based on Rhodamine B, named S1‑4, a new compound that has not been previously reported. This probe exhibited good linear range under physiological fluid viscosity and pH; it has good selectivity for Hcy, and is able to avoid interference from other amino acids and metal ions. This probe can effectively measure the level of Hcy in the blood sera of healthy people and in patients with transient cerebral ischemia and cerebral infarction. However, satisfactory specificity and sensitivity to Hcy was not achieved according to receiver operating characteristic curve analysis. Overall, results from the present study suggested that following further optimization, this probe may be potentially applied in the diagnosis of cerebral infarction.
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1 

Zhong C, Xu T, Xu T, Peng Y, Wang A, Wang J, Peng H, Li Q, Geng D, Zhang D, et al: Plasma homocysteine and prognosis of acute ischemic stroke: A gender-specific analysis from CATIS randomized clinical trial. Mol Neurobiol. 54:2022–2030. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Liu J, Zhu Y, Wu Y, Liu Y, Teng Z and Hao Y: Association of carotid atherosclerosis and recurrent cerebral infarction in the Chinese population: A meta-analysis. Neuropsychiatr Dis Treat. 13:527–533. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Sun LC, Chen R, Fu C, Chen Y, Wu Q, Chen R, Lin X and Luo S: Efficacy and safety of botulinum toxin type a for limb spasticity after stroke: A meta-analysis of randomized controlled trials. Biomed Res Int. 2019:83293062019. View Article : Google Scholar : PubMed/NCBI

4 

Tsai CF, Anderson N, Thomas B and Sudlow CL: Comparing risk factor profiles between intracerebral hemorrhage and ischemic stroke in Chinese and white populations: Systematic review and meta-analysis. PLoS One. 11:e01517432016. View Article : Google Scholar : PubMed/NCBI

5 

Wu W, Guan Y, Xu K, Fu XJ, Lei XF, Lei LJ, Zhang ZQ, Cheng Y and Li YQ: Plasma homocysteine levels predict the risk of acute cerebral infarction in patients with carotid artery lesions. Mol Neurobiol. 54:2510–2517. 2016. View Article : Google Scholar

6 

Fox CK, Mackay MT, Dowling MM, Pergami P, Titomanlio L and Deveber G; SIPS Investigators, : Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk. Dev Med Child Neurol. 59:38–44. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Cioni G, Marcucci R, Gori AM, Valente S, Giglioli C, Gensini GF, Abbate R and Boddi M: Increased homocysteine and lipoprotein(a) levels highlight systemic atherosclerotic burden in patients with a history of acute coronary syndromes. J Vasc Surg. 64:163–170. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Kumar M and Sandhir R: Neuroprotective effect of hydrogen sulfide in hyperhomocysteinemia is mediated through antioxidant action involving Nrf2. Neuromolecular Med. 20:475–490. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Senturk B, Akdeniz B, Yilmaz MB, Ozcan Kahraman B, Acar B, Uslu S and Birlik M: Whole blood viscosity in systemic sclerosis: A potential biomarker of pulmonary hypertension? Clin Rheumatol. May 26–2019.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

10 

Ling-CongHong-ZhaoYu-WangYu-LiXin-Sui, . The serum homocysteine level in patients with acute ischemic stroke (AIS) after thrombolysis and its relationship with clinical outcomes. Rev Assoc Med Bras (1992). 64:438–442. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Wu X, Zhang L, Miao Y, Yang J, Wang X, Wang CC, Feng J and Wang L: Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis. Redox Biol. 20:46–59. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Kim J, Pyo S, Yoon DW, Lee S, Lim JY, Heo JS, Lee S and Shin C: The co-existence of elevated high sensitivity C-reactive protein and homocysteine levels is associated with increased risk of metabolic syndrome: A 6-year follow-up study. PLoS One. 13:e02061572018. View Article : Google Scholar : PubMed/NCBI

13 

Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X and Sun H: Catalpol inhibits homocysteine-induced oxidation and inflammation via inhibiting Nox4/NF-κB and GRP78/PERK pathways in human aorta endothelial cells. Inflammation. 42:64–80. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Saoji R, Das RS, Desai M, Pasi A, Sachdeva G, Das TK and Khatkhatay MI: Association of high-density lipoprotein, triglycerides, and homocysteine with bone mineral density in young Indian tribal women. Arch Osteoporos. 13:1082018. View Article : Google Scholar : PubMed/NCBI

15 

Liu J, Quan J, Li Y, Wu Y and Yang L: Blood homocysteine levels could predict major adverse cardiac events in patients with acute coronary syndrome: A STROBE-compliant observational study. Medicine (Baltimore). 97:e126262018. View Article : Google Scholar : PubMed/NCBI

16 

Zhang W, Liu J, Yu Y, Han Q, Cheng T, Shen J, Wang B and Jiang Y: A novel near-infrared fluorescent probe for highly selective detection of cysteine and its application in living cells. Talanta. 185:477–482. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Yang X, Wang Y, Zhao MX and Yang W: A colorimetric and near-infrared fluorescent probe for cysteine and homocysteine detection. Spectrochim Acta A Mol Biomol Spectrosc. 212:10–14. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Li X, Ma Y and Zhu Y: The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients . Exp Ther Med 18: 2675-2680, 2019.
APA
Zhao, X., Li, X., Ma, Y., & Zhu, Y. (2019). The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients . Experimental and Therapeutic Medicine, 18, 2675-2680. https://doi.org/10.3892/etm.2019.7833
MLA
Zhao, X., Li, X., Ma, Y., Zhu, Y."The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients ". Experimental and Therapeutic Medicine 18.4 (2019): 2675-2680.
Chicago
Zhao, X., Li, X., Ma, Y., Zhu, Y."The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients ". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2675-2680. https://doi.org/10.3892/etm.2019.7833
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Li X, Ma Y and Zhu Y: The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients . Exp Ther Med 18: 2675-2680, 2019.
APA
Zhao, X., Li, X., Ma, Y., & Zhu, Y. (2019). The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients . Experimental and Therapeutic Medicine, 18, 2675-2680. https://doi.org/10.3892/etm.2019.7833
MLA
Zhao, X., Li, X., Ma, Y., Zhu, Y."The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients ". Experimental and Therapeutic Medicine 18.4 (2019): 2675-2680.
Chicago
Zhao, X., Li, X., Ma, Y., Zhu, Y."The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients ". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2675-2680. https://doi.org/10.3892/etm.2019.7833
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