Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats

  • Authors:
    • Dongmei Chen
    • Chunling Xiao
    • Huanrong Jin
    • Biao Yang
    • Jiayu Niu
    • Siyuan Yan
    • Ye Sun
    • Yuan Zhou
    • Xiangming Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3484-3492
    |
    Published online on: August 23, 2019
       https://doi.org/10.3892/etm.2019.7934
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Atmospheric particulate matter with a diameter <2.5 µm (PM2.5) and pollution are worldwide environmental problems and may have negative effects on cardiovascular disease through the lung and gut. The dynamics of intestinal microflora in response to particulate pollutants is unclear. The present study investigated changes in the gut microbiota related to pollutant exposure using spontaneously hypertensive rats (SHR). DNA was extracted from fecal samples. Amplicon Generation and the quality control of PCR products were performed. PCR products was sequenced on an Illumina HiSeq 2500 platform. Data analysis included: operational taxonomic unit (OTU) clustering and species annotation, alpha diversity, beta diversity, principal coordinates analysis (PCoA), and the use of PICRUSt bioinformatics software. The microbial diversity of the SHR rats was inversely associated with exposure to pollutants. In terms of relative abundance, 24 bacterial genera and 2 genera in particular (Actinobacillus and Fusobacterium) significantly declined, and one genus (Treponema) increased. Moreover, pollutant exposure was associated with the accumulation of genes from the gut microbiota that are implicated in cardiovascular diseases. From the long-term exposure experiment, rats appeared to respond to pollutant injury. In conclusion, these results suggest that the effects of atmospheric pollutants on organisms are not limited to the respiratory tract, but also include the gastrointestinal tract. Pollutants are likely to influence the intestinal microbiota and promote the progression of cardiovascular disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ma M, Li S, Jin H, Zhang Y, Xu J, Chen D, Kuimin C, Yuan Z and Xiao C: Characteristics and oxidative stress on rats and traffic policemen of ambient fine particulate matter from Shenyang. Sci Total Environ. 526:110–115. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Stockfelt L, Andersson EM, Molnár P, Gidhagen L, Segersson D, Rosengren A, Barregard L and Sallsten G: Long-term effects of total and source-specific particulate air pollution on incident cardiovascular disease in Gothenburg, Sweden. Environ Res. 158:61–71. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Chen H, Goldberg MS and Villeneuve PJ: A systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases. Rev Environ Health. 23:243–297. 2008.PubMed/NCBI

4 

Chen YC, Weng YH, Chiu YW and Yang CY: Short-term effects of coarse particulate matter on hospital admissions for cardiovascular diseases: A case-crossover study in a tropical city. J Toxicol Environ Health A. 78:1241–1253. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Bhalla DK: Ozone-induced lung inflammation and mucosal barrier disruption: Toxicology, mechanisms, and implications. J Toxicol Environ Health B Crit Rev. 2:31–86. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Salim SY, Kaplan GG and Madsen KL: Air pollution effects on the gut microbiota: A link between exposure and inflammatory disease. Gut Microbes. 5:215–219. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zuo T, Kamm MA, Colombel JF and Ng SC: Urbanization and the gut microbiota in health and inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 15:440–452. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Sekirov I, Russell SL, Antunes LC and Finlay BB: Gut microbiota in health and disease. Physiol Rev. 90:859–904. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Shouval DS and Rufo PA: The role of environmental factors in the pathogenesis of inflammatory bowel diseases: A Review. JAMA Pediatr. 171:999–1005. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Calkins BM: A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci. 34:1841–1854. 1989. View Article : Google Scholar : PubMed/NCBI

11 

Mutlu EA, Engen PA, Soberanes S, Urich D, Forsyth CB, Nigdelioglu R, Chiarella SE, Radigan KA, Gonzalez A, Jakate S, et al: Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Part Fibre Toxicol. 8:192011. View Article : Google Scholar : PubMed/NCBI

12 

Kinross JM, Darzi AW and Nicholson JK: Gut microbiome-host interactions in health and disease. Genome Med. 3:142011. View Article : Google Scholar : PubMed/NCBI

13 

Barton W, Penney NC, Cronin O, Garcia-Perez I, Molloy MG, Holmes E, Shanahan F, Cotter PD and OSullivan O: The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level. Gut. 67:625–633. 2018.PubMed/NCBI

14 

Kowalski TJ, Liu SM, Leibel RL and Chua SC Jr: Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes. 50:425–435. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Tang WH and Hazen SL: The gut microbiome and its role in cardiovascular diseases. Circulation. 135:1008–1010. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Man WH, de Steenhuijsen Piters WA and Bogaert D: The microbiota of the respiratory tract: Gatekeeper to respiratory health. Nat Rev Microbiol. 15:259–270. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Hernández AF and Tsatsakis AM: Human exposure to chemical mixtures: Challenges for the integration of toxicology with epidemiology data in risk assessment. Food Chem Toxicol. 103:188–193. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Moller W, Haussinger K, Winkler-Heil R, Stahlhofen W, Meyer T, Hofmann W and Heyder J: Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjects. J Appl Physiol (1985). 97:2200–2206. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Xiao C, Li S, Zhou W, Shang D, Zhao S, Zhu X, Chen K and Wang R: The effect of air pollutants on the microecology of the respiratory tract of rats. Environ Toxicol Pharmacol. 36:588–594. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ma Y, Ding S, Liu G, Fang J, Yan W, Duraipandiyan V, Al-Dhabi NA, Esmail GA and Jiang H: Egg protein transferrin-derived peptides IRW and IQW regulate citrobacter rodentium-induced, inflammation-related microbial and metabolomic profiles. Front Microbiol. 10:6432019. View Article : Google Scholar : PubMed/NCBI

21 

Catry E, Bindels LB, Tailleux A, Lestavel S, Neyrinck AM, Goossens JF, Lobysheva I, Plovier H, Essaghir A, Demoulin JB, et al: Targeting the gut microbiota with inulin-type fructans: Preclinical demonstration of a novel approach in the management of endothelial dysfunction. Gut. 67:271–283. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Henning SM, Yang J, Shao P, Lee RP, Huang J, Ly A, Hsu M, Lu QY, Thames G, Heber D, et al: Health benefit of vegetable/fruit juice-based diet: Role of microbiome. Sci Rep. 7:21672017. View Article : Google Scholar : PubMed/NCBI

23 

Yang Y, Deng Y and Cao L: Characterising the interspecific variations and convergence of gut microbiota in Anseriformes herbivores at wintering areas. Sci Rep. 6:326552016. View Article : Google Scholar : PubMed/NCBI

24 

Shatzkes K, Tang C, Singleton E, Shukla S, Zuena M, Gupta S, Dharani S, Rinaggio J, Connell ND and Kadouri DE: Effect of predatory bacteria on the gut bacterial microbiota in rats. Sci Rep. 7:434832017. View Article : Google Scholar : PubMed/NCBI

25 

Chakradhar S: A curious connection: Teasing apart the link between gut microbes and lung disease. Nat Med. 23:402–404. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Barrett KE and Wu GD: Influence of the microbiota on host physiology - moving beyond the gut. J Physiol. 595:433–435. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Arrieta MC, Bistritz L and Meddings JB: Alterations in intestinal permeability. Gut. 55:1512–1520. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Mortaz E, Adcock IM, Folkerts G, Barnes PJ, Paul Vos A and Garssen J: Probiotics in the management of lung diseases. Mediators Inflamm. 2013:7510682013. View Article : Google Scholar : PubMed/NCBI

29 

Wang J, Gao Y and Zhao F: Phage-bacteria interaction network in human oral microbiome. Environ Microbiol. 18:2143–2158. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, et al: The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 342:971–976. 2013. View Article : Google Scholar : PubMed/NCBI

31 

De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Bäckhed F and Mithieux G: Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell. 156:84–96. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y and Hazen SL: Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 368:1575–1584. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, et al: Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 19:576–585. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Tang WH, Kitai T and Hazen SL: Gut microbiota in cardiovascular health and disease. Circ Res. 120:1183–1196. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Kostovcik M, Bateman CC, Kolarik M, Stelinski LL, Jordal BH and Hulcr J: The ambrosia symbiosis is specific in some species and promiscuous in others: Evidence from community pyrosequencing. ISME J. 9:126–138. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen D, Xiao C, Jin H, Yang B, Niu J, Yan S, Sun Y, Zhou Y and Wang X: Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats. Exp Ther Med 18: 3484-3492, 2019.
APA
Chen, D., Xiao, C., Jin, H., Yang, B., Niu, J., Yan, S. ... Wang, X. (2019). Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats. Experimental and Therapeutic Medicine, 18, 3484-3492. https://doi.org/10.3892/etm.2019.7934
MLA
Chen, D., Xiao, C., Jin, H., Yang, B., Niu, J., Yan, S., Sun, Y., Zhou, Y., Wang, X."Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats". Experimental and Therapeutic Medicine 18.5 (2019): 3484-3492.
Chicago
Chen, D., Xiao, C., Jin, H., Yang, B., Niu, J., Yan, S., Sun, Y., Zhou, Y., Wang, X."Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3484-3492. https://doi.org/10.3892/etm.2019.7934
Copy and paste a formatted citation
x
Spandidos Publications style
Chen D, Xiao C, Jin H, Yang B, Niu J, Yan S, Sun Y, Zhou Y and Wang X: Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats. Exp Ther Med 18: 3484-3492, 2019.
APA
Chen, D., Xiao, C., Jin, H., Yang, B., Niu, J., Yan, S. ... Wang, X. (2019). Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats. Experimental and Therapeutic Medicine, 18, 3484-3492. https://doi.org/10.3892/etm.2019.7934
MLA
Chen, D., Xiao, C., Jin, H., Yang, B., Niu, J., Yan, S., Sun, Y., Zhou, Y., Wang, X."Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats". Experimental and Therapeutic Medicine 18.5 (2019): 3484-3492.
Chicago
Chen, D., Xiao, C., Jin, H., Yang, B., Niu, J., Yan, S., Sun, Y., Zhou, Y., Wang, X."Exposure to atmospheric pollutants is associated with alterations of gut microbiota in spontaneously hypertensive rats". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3484-3492. https://doi.org/10.3892/etm.2019.7934
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team