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Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF

  • Authors:
    • Wei Huang
    • Wei Gan
    • An Huang
    • Yulei Fu
    • Yuzhi Shang
    • Yue Chen
    • Zhao Tian
    • Yun Zhang
    • Gang Fang
  • View Affiliations / Copyright

    Affiliations: The First Clinical Faculty, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530023, P.R. China, College of Pharmacy, Minzu University of China, Beijing 100081, P.R. China, Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China, Graduate School of Hubei University for Nationalities, Enshi, Hubei 445000, P.R. China, Laboratory of Zhuang Medicine Prescriptions Basis and Application Research, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3470-3474
    |
    Published online on: September 6, 2019
       https://doi.org/10.3892/etm.2019.7977
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Abstract

Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients, and its effect on the levels of serum inflammatory cytokines, norepinephrine (NE) and brain‑derived neurotrophic factor (BDNF) were investigated. A total of 104 patients with depression and chronic diarrhea admitted to The First Clinical Faculty, Guangxi University of Traditional Chinese Medicine from July 2014 to June 2018 were randomly divided into the observation group (n=56) and the control group (n=48). The observation group was treated with electroacupuncture combined with probiotics, and the control group was given conventional drugs for depression and chronic diarrhea. The Hamilton Depression Rating Scale (HAM‑D) score and the abdominal symptom score were evaluated before treatment and at 3 weeks after treatment. Changes in the levels of serum inflammatory cytokines [interleukin (IL)‑6, IL‑2 and tumor necrosis factor (TNF)‑α] as well as the levels of NE and BDNF in the two groups of patients before and after treatment were determined using radioimmunoassay. Compared with those in the control group, the symptoms of depression and diarrhea in the observation group were remarkably alleviated (p<0.05). After treatment, the serum cytokine levels in the two groups of patients were decreased, and the decreased level of serum inflammatory cytokines in the observation group was not obviously different from that in the control group. Besides, the serum BDNF level in the observation group was also reduced (p<0.05). The overall efficacy of the observation group was superior to that of the control group, showing a statistical difference. Electroacupuncture combined with probiotics brings good efficacy to patients with depression and chronic diarrhea, which is worthy of clinical promotion and development.
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1 

Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y and Shibata S: Night eating model shows time-specific depression-like behavior in the forced swimming test. Sci Rep. 8:10812018. View Article : Google Scholar : PubMed/NCBI

2 

Barua CC, Haloi P, Saikia B, Sulakhiya K, Pathak DC, Tamuli S, Rizavi H and Ren X: Zanthoxylum alatum abrogates lipopolysaccharide-induced depression-like behaviours in mice by modulating neuroinflammation and monoamine neurotransmitters in the hippocampus. Pharm Biol. 56:245–252. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Veltman EM, Lamers F, Comijs HC, Stek ML, van der Mast RC and Rhebergen D: Inflammatory markers and cortisol parameters across depressive subtypes in an older cohort. J Affect Disord. 234:54–58. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Innes K, Hooper J, Bramley M and DahDah P: Creation of aclinical classification. International statistical classification of diseases and related health problems--10th revision, Australian modification (ICD-10-AM). Health Inf Manag. 27:31–38. 1997.PubMed/NCBI

5 

Liu S and Ren JA: Pathogenesis, diagnosis and treatment of anemia in inflammatory bowel disease. Zhonghua Wei Chang Wai Ke Za Zhi. 16:398–400. 2013.(In Chinese). PubMed/NCBI

6 

Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kühn M, Schuld A and Pollmächer T: Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: Effects of confounding factors and diagnosis. J Psychiatr Res. 33:407–418. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Levine J, Barak Y, Chengappa KN, Rapoport A, Rebey M and Barak V: Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology. 40:171–176. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Frommberger UH, Bauer J, Haselbauer P, Fräulin A, Riemann D and Berger M: Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: Comparison between the acute state and after remission. Eur Arch Psychiatry Clin Neurosci. 247:228–233. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Słuzewska A, Rybakowski JK, Laciak M, Mackiewicz A, Sobieska M and Wiktorowicz K: Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine. Ann N Y Acad Sci. 762:474–476. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Talati M and Hemnes A: Fatty acid metabolism in pulmonary arterial hypertension: Role in right ventricular dysfunction and hypertrophy. Pulm Circ. 5:269–278. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A and Wan Y: Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. Nat Commun. 3:10082012. View Article : Google Scholar : PubMed/NCBI

12 

Luther J, Gala M, Patel SJ, Dave M, Borren N, Xavier RJ and Ananthakrishnan AN: Loss of response to anti-tumor necrosis factor alpha therapy in Crohn's Disease is not associated with emergence of novel inflammatory pathways. Dig Dis Sci. 63:738–745. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Lozovoy MA, Simão AN, Morimoto HK, Iryioda TM, Panis C, Reiche EM, Borelli SD, Oliveira SR, Cecchini R and Dichi I: Hypertension is associated with serologically active disease in patients with systemic lupus erythematosus: Role of increased Th1/Th2 ratio and oxidative stress. Scand J Rheumatol. 43:59–62. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Bai Y, Song L, Dai G, Xu M, Zhu L, Zhang W, Jing W and Ju W: Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection. Steroids. 135:73–78. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Karmakar I, Haldar S, Chakraborty M, Chaudhury K, Dewanjee S and Haldar PK: Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage by Zanthoxylum alatum. Pharm Biol. 54:503–508. 2016. View Article : Google Scholar : PubMed/NCBI

16 

He SC, Wu S, Wang C, Du XD, Yin G, Jia Q, Zhang Y, Wang L, Soares JC and Zhang XY: Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers. J Affect Disord. 236:157–163. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G and Aubry JM: Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 109:143–148. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S and Iyo M: Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry. 54:70–75. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Dong JP, Sun WY, Wang S, Wu ZQ and Liu F: Clinical observation on head point-through-point electroacupuncture for treatment of poststroke depression. Zhongguo Zhen Jiu. 27:241–244. 2007.(In Chinese). PubMed/NCBI

20 

Liu Q, Li B, Zhu HY, Wang YQ, Yu J and Wu GC: Glia atrophy in the hippocampus of chronic unpredictable stress-induced depression model rats is reversed by electroacupuncture treatment. J Affect Disord. 128:309–313. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang W, Gan W, Huang A, Fu Y, Shang Y, Chen Y, Tian Z, Zhang Y and Fang G: Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF. Exp Ther Med 18: 3470-3474, 2019.
APA
Huang, W., Gan, W., Huang, A., Fu, Y., Shang, Y., Chen, Y. ... Fang, G. (2019). Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF. Experimental and Therapeutic Medicine, 18, 3470-3474. https://doi.org/10.3892/etm.2019.7977
MLA
Huang, W., Gan, W., Huang, A., Fu, Y., Shang, Y., Chen, Y., Tian, Z., Zhang, Y., Fang, G."Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF". Experimental and Therapeutic Medicine 18.5 (2019): 3470-3474.
Chicago
Huang, W., Gan, W., Huang, A., Fu, Y., Shang, Y., Chen, Y., Tian, Z., Zhang, Y., Fang, G."Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3470-3474. https://doi.org/10.3892/etm.2019.7977
Copy and paste a formatted citation
x
Spandidos Publications style
Huang W, Gan W, Huang A, Fu Y, Shang Y, Chen Y, Tian Z, Zhang Y and Fang G: Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF. Exp Ther Med 18: 3470-3474, 2019.
APA
Huang, W., Gan, W., Huang, A., Fu, Y., Shang, Y., Chen, Y. ... Fang, G. (2019). Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF. Experimental and Therapeutic Medicine, 18, 3470-3474. https://doi.org/10.3892/etm.2019.7977
MLA
Huang, W., Gan, W., Huang, A., Fu, Y., Shang, Y., Chen, Y., Tian, Z., Zhang, Y., Fang, G."Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF". Experimental and Therapeutic Medicine 18.5 (2019): 3470-3474.
Chicago
Huang, W., Gan, W., Huang, A., Fu, Y., Shang, Y., Chen, Y., Tian, Z., Zhang, Y., Fang, G."Efficacy of electroacupuncture combined with probiotics for depression and chronic diarrhea in patients and effect on serum inflammatory cytokines, NE and BDNF". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3470-3474. https://doi.org/10.3892/etm.2019.7977
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