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Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients

  • Authors:
    • Haifeng Zhang
    • Yajun Lian
    • Nanchang Xie
    • Xuan Cheng
    • Chen Chen
    • Hongliang Xu
    • Yake Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3375-3382
    |
    Published online on: September 9, 2019
       https://doi.org/10.3892/etm.2019.7988
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Abstract

Botulinum toxin A (BTX‑A) is a promising therapeutic modality against trigeminal neuralgia (TN) with certain controversies pertaining to its application. To provide further information on factors influencing the treatment outcomes of BTX‑A, a retrospective study with 152 patients with TN treated with BTX‑A was performed. The starting time and duration of the therapeutic effect, as well as side effects, of BTX‑A in the treatment of TN were analyzed by sex, age, course of disease, number of branches and injected dose. A total of 136 patients exhibited symptom improvement within 2 weeks following BTX‑A treatment as evaluated using a visual analog scale (VAS). The effect of BTX‑A was sustained throughout the initial 6 months of the follow‑up and was demonstrated to persist for as long as 28 months. Female sex, short disease course and high injection dose (>70 units) were associated with lower long‑term VAS scores. Patients receiving short‑term medium‑(50‑70 units) or high‑dose injections were more likely to be completely cured. Patients with a median disease course (1‑10 years) or multiple branches were more likely to exhibit facial asymmetry. Based on the stratified analysis, female patients with a median disease course (1‑10 years) exhibited a higher incidence of side effects and male patients achieved better treatment outcomes with high BTX‑A doses. BTX‑A effectively alleviated patients with TN in both short or long term, although the treatment efficacy may depend on patient characteristics.
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1 

Olesen J and Steiner TJ: The International classification of headache disorders, 2nd edn (ICDH-II). J Neurol Neurosurg Psychiatry. 75:808–811. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Katusic S, Beard CM, Bergstralth E and Kurland LT: Incidence and clinical features of trigeminal neuralgia, Rochester, Minnesota, 1945–1984. Ann Neurol. 27:89–95. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Ngeow WC and Nair R: Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109:e47–e50. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Devor M, Amir R and Rappaport ZH: Pathophysiology of trigeminal neuralgia: The ignition hypothesis. Clin J Pain. 18:4–13. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Cheshire WP: Trigeminal neuralgia: For one nerve a multitude of treatments. Expert Rev Neurother. 7:1565–1579. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Merrison AF and Fuller G: Treatment options for trigeminal neuralgia. BMJ. 327:1360–1361. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Castillo-Alvarez F, Hernando de la Barcena I and Marzo-Sola ME: Botulinum toxin in trigeminal neuralgia. Med Clin (Barc). 148:28–32. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Humeau Y, Doussau F, Grant NJ and Poulain B: How botulinum and tetanus neurotoxins block neurotransmitter release. Biochimie. 82:427–446. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Pearce LB, First ER, Maccallum RD and Gupta A: Pharmacologic characterization of botulinum toxin for basic science and medicine. Toxicon. 35:1373–1412. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Lian YJ, Wei HL, Zhang BA, et al: Treatment of 795 facial spasm and local dystonia with Botulinum toxin A. J Zhengzhou Univ (Med Sci). 44:32009.

11 

Aurora SK, Winner P, Freeman MC, Spierings EL, Heiring JO, DeGryse RE, VanDenburgh AM, Nolan ME and Turkel CC: OnabotulinumtoxinA for treatment of chronic migraine: Pooled analyses of the 56-week PREEMPT clinical program. Headache. 51:1358–1373. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Diener HC, Dodick DW, Aurora SK, Turkel CC, DeGryse RE, Lipton RB, Silberstein SD and Brin MF; PREEMPT 2 Chronic Migraine Study Group, : OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia. 30:804–814. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Micheli F, Scorticati MC and Raina G: Beneficial effects of botulinum toxin type a for patients with painful tic convulsif. Clin Neuropharmacol. 25:260–262. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Wu CJ, Lian YJ, Zheng YK, Zhang HF, Chen Y, Xie NC and Wang LJ: Botulinum toxin type A for the treatment of trigeminal neuralgia: Results from a randomized, double-blind, placebo-controlled trial. Cephalalgia. 32:443–450. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Hu Y, Guan X, Fan L, Li M, Liao Y, Nie Z and Jin L: Therapeutic efficacy and safety of botulinum toxin type A in trigeminal neuralgia: A systematic review. J Headache Pain. 14:722013. View Article : Google Scholar : PubMed/NCBI

16 

Morra ME, Elgebaly A, Elmaraezy A, Khalil AM, Altibi AM, Vu TL, Mostafa MR, Huy NT and Hirayama K: Therapeutic efficacy and safety of botulinum toxin a therapy in trigeminal neuralgia: A systematic review and meta-analysis of randomized controlled trials. J Headache Pain. 17:632016. View Article : Google Scholar : PubMed/NCBI

17 

Headache Classification Subcommittee of the International Headache Society, . The International Classification of Headache Disorders: 2nd edition. Cephalalgia. 24 (Suppl 1):S9–S160. 2004.

18 

Lee JS: Pain measurement: Understanding existing tools and their application in the emergency department. Emerg Med (Fremantle). 13:279–287. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Ross I and Robert G: R: A language for data analysis and graphics. J Computational Graphical Statistics. 5:299–314. 1996. View Article : Google Scholar

20 

Zakrzewska JM: Botulinum toxin type A for trigeminal neuralgia-we have the prima facie evidence. Cephalalgia. 32:1156–1157. 2012. View Article : Google Scholar

21 

Zhang H, Lian Y, Ma Y, Chen Y, He C, Xie N and Wu C: Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: Observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial. J Headache Pain. 15:652014. View Article : Google Scholar : PubMed/NCBI

22 

Li S, Lian YJ, Chen Y, Zhang HF, Ma YQ, He CH, Wu CJ, Xie NC, Zheng YK and Zhang Y: Therapeutic effect of botulinum toxin-a in 88 patients with trigeminal neuralgia with 14-month follow-up. J Headache Pain. 15:432014. View Article : Google Scholar : PubMed/NCBI

23 

Shen JH, Lian YJ and Zheng YK: Effect of botulinum toxin type a on clssic trigeminal neuralgia. Chin J Rehab Med. 26:22011.

24 

Fabregat G, De Andrés J, Villanueva-Pérez VL and Asensio-Samper JM: Subcutaneous and perineural botulinum toxin type A for neuropathic pain: A descriptive review. Clin J Pain. 29:1006–1012. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Klein AW: The therapeutic potential of botulinum toxin. Dermatologic Surgery. 30:452–455. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Aoki KR: Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A. Neurotoxicology. 26:785–793. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Gazerani P, Pedersen NS, Staahl C, Drewes AM and Arendt-Nielsen L: Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin. Pain. 141:60–69. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Lian Y, Xie N, Cheng X, Chen C, Xu H and Zheng Y: Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients. Exp Ther Med 18: 3375-3382, 2019.
APA
Zhang, H., Lian, Y., Xie, N., Cheng, X., Chen, C., Xu, H., & Zheng, Y. (2019). Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients. Experimental and Therapeutic Medicine, 18, 3375-3382. https://doi.org/10.3892/etm.2019.7988
MLA
Zhang, H., Lian, Y., Xie, N., Cheng, X., Chen, C., Xu, H., Zheng, Y."Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients". Experimental and Therapeutic Medicine 18.5 (2019): 3375-3382.
Chicago
Zhang, H., Lian, Y., Xie, N., Cheng, X., Chen, C., Xu, H., Zheng, Y."Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3375-3382. https://doi.org/10.3892/etm.2019.7988
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Lian Y, Xie N, Cheng X, Chen C, Xu H and Zheng Y: Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients. Exp Ther Med 18: 3375-3382, 2019.
APA
Zhang, H., Lian, Y., Xie, N., Cheng, X., Chen, C., Xu, H., & Zheng, Y. (2019). Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients. Experimental and Therapeutic Medicine, 18, 3375-3382. https://doi.org/10.3892/etm.2019.7988
MLA
Zhang, H., Lian, Y., Xie, N., Cheng, X., Chen, C., Xu, H., Zheng, Y."Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients". Experimental and Therapeutic Medicine 18.5 (2019): 3375-3382.
Chicago
Zhang, H., Lian, Y., Xie, N., Cheng, X., Chen, C., Xu, H., Zheng, Y."Factors affecting the therapeutic effect of botulinum toxin A on trigeminal neuralgia: A follow‑up retrospective study of 152 patients". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3375-3382. https://doi.org/10.3892/etm.2019.7988
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