Open Access

TAF‑Iβ deficiency inhibits proliferation and promotes apoptosis by rescuing PP2A and inhibiting the AKT/GSK‑3β pathway in leukemic cells

  • Authors:
    • Yanfeng Liu
    • Yan Jia
    • Xiao Fu
    • Pengcheng He
  • View Affiliations

  • Published online on: September 17, 2019     https://doi.org/10.3892/etm.2019.8012
  • Pages: 3801-3808
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Template‑activating factor Iβ (TAF‑Iβ) has been associated with numerous pathophysiological processes and has been reported as an oncogene responsible for the regulation of important signaling pathways in various types of solid tumor; however, few studies have investigated the role of TAF‑Iβ in leukemia. The present study reported the upregulated expression of TAF‑Iβ in 36 patients with acute leukemia and six leukemic cell lines. In addition, TAF‑Iβ‑knockdown (KD) cells were generated via RNA interference. TAF‑Iβ KD not only inhibited the proliferation of leukemia cells but also induced apoptosis. Furthermore, it was revealed that the mechanism underlying these effects may be associated with the upregulation of protein phosphatase type 2A and inhibition of the protein kinase B/glycogen synthase kinase‑3β signaling pathway. Collectively, the findings demonstrated that TAF‑Iβ serves an important role in various types of leukemia and may be considered as a potential therapeutic target for the treatment of leukemia.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Y, Jia Y, Fu X and He P: TAF‑Iβ deficiency inhibits proliferation and promotes apoptosis by rescuing PP2A and inhibiting the AKT/GSK‑3β pathway in leukemic cells. Exp Ther Med 18: 3801-3808, 2019
APA
Liu, Y., Jia, Y., Fu, X., & He, P. (2019). TAF‑Iβ deficiency inhibits proliferation and promotes apoptosis by rescuing PP2A and inhibiting the AKT/GSK‑3β pathway in leukemic cells. Experimental and Therapeutic Medicine, 18, 3801-3808. https://doi.org/10.3892/etm.2019.8012
MLA
Liu, Y., Jia, Y., Fu, X., He, P."TAF‑Iβ deficiency inhibits proliferation and promotes apoptosis by rescuing PP2A and inhibiting the AKT/GSK‑3β pathway in leukemic cells". Experimental and Therapeutic Medicine 18.5 (2019): 3801-3808.
Chicago
Liu, Y., Jia, Y., Fu, X., He, P."TAF‑Iβ deficiency inhibits proliferation and promotes apoptosis by rescuing PP2A and inhibiting the AKT/GSK‑3β pathway in leukemic cells". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3801-3808. https://doi.org/10.3892/etm.2019.8012