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Article

Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment

  • Authors:
    • Luisa Di Costanzo
    • Emanuele Scala
    • Giuseppina Caiazzo
    • Serena Lembo
    • Rita Marino
    • Matteo Megna
    • Angela Patrì
    • Roberta Di Caprio
    • Anna Balato
  • View Affiliations / Copyright

    Affiliations: Dermatology Unit, Azienda Ospedaliera Rilievo Nazionale ‘G. Rummo’, Benevento I-82100, Italy, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples I-80131, Italy, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples I-80131, Italy, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’ University of Salerno, Salerno I-84041, Italy, Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples I-80122, Italy
  • Pages: 4120-4124
    |
    Published online on: September 17, 2019
       https://doi.org/10.3892/etm.2019.8015
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Abstract

Psoriasis over‑expresses several inflammatory mediators, which impacts the activity of melanocytes. Tyrosinase (Tyr) and microphthalmia‑associated transcription factor (MITF) are the primary regulators of melanogenesis. Furthermore, bone morphogenetic proteins (BMPs) modulate various pathobiologic processes including inflammation, melanogenesis and melanomagenesis. To determine the association between psoriasis and melanogenesis, psoriatic lesional skin was screened through gene expression, immunohistochemistry, immunogold staining and melanin content assays. The present study detected a decreased expression of Tyr, MITF and BMP‑4 in psoriatic lesional skin compared with healthy skin. Tyr, BMP‑4 and melanin content were also evaluated in the psoriatic lesional skin of patients receiving adalimumab therapy, before and after 16 weeks of treatment. TNF‑α blockade modulated the Tyr, BMP‑4 and melanin content of the patient skin lesions, which supported the hypothesis that hyper‑pigmentation may occur in areas of psoriatic plaque after biological treatment. The present study confirmed the influence of the psoriatic pro‑inflammatory network on melanogenesis, exerting an inhibitory effect mediated by TNF‑α. Furthermore, the results regarding BMP‑4 in the present study add another important element to the mechanism of psoriasis.
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Copy and paste a formatted citation
Spandidos Publications style
Di Costanzo L, Scala E, Caiazzo G, Lembo S, Marino R, Megna M, Patrì A, Di Caprio R and Balato A: Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment. Exp Ther Med 18: 4120-4124, 2019.
APA
Di Costanzo, L., Scala, E., Caiazzo, G., Lembo, S., Marino, R., Megna, M. ... Balato, A. (2019). Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment. Experimental and Therapeutic Medicine, 18, 4120-4124. https://doi.org/10.3892/etm.2019.8015
MLA
Di Costanzo, L., Scala, E., Caiazzo, G., Lembo, S., Marino, R., Megna, M., Patrì, A., Di Caprio, R., Balato, A."Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment". Experimental and Therapeutic Medicine 18.5 (2019): 4120-4124.
Chicago
Di Costanzo, L., Scala, E., Caiazzo, G., Lembo, S., Marino, R., Megna, M., Patrì, A., Di Caprio, R., Balato, A."Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4120-4124. https://doi.org/10.3892/etm.2019.8015
Copy and paste a formatted citation
x
Spandidos Publications style
Di Costanzo L, Scala E, Caiazzo G, Lembo S, Marino R, Megna M, Patrì A, Di Caprio R and Balato A: Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment. Exp Ther Med 18: 4120-4124, 2019.
APA
Di Costanzo, L., Scala, E., Caiazzo, G., Lembo, S., Marino, R., Megna, M. ... Balato, A. (2019). Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment. Experimental and Therapeutic Medicine, 18, 4120-4124. https://doi.org/10.3892/etm.2019.8015
MLA
Di Costanzo, L., Scala, E., Caiazzo, G., Lembo, S., Marino, R., Megna, M., Patrì, A., Di Caprio, R., Balato, A."Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment". Experimental and Therapeutic Medicine 18.5 (2019): 4120-4124.
Chicago
Di Costanzo, L., Scala, E., Caiazzo, G., Lembo, S., Marino, R., Megna, M., Patrì, A., Di Caprio, R., Balato, A."Possible role of BMP‑4 in the hyper‑pigmentation of psoriatic plaques after anti‑TNF‑α treatment". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4120-4124. https://doi.org/10.3892/etm.2019.8015
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