Clinicopathological features and prognostic analysis of 49 cases with crescentic glomerulonephritis

Wu,Ting; Peng,Jiajia; Meng,Ting; Liu,Qianqian; Ao,Xiang; Lin,Wei; Yin,Hongling; Chen,Jinbiao; Pu,Jiaxi; Peng,Zhangzhe; Peng,Weisheng; Li,Xiaozhao; Xiao,Xiangcheng; Zhou,Qiaoling; Zhong,Yong; Xiao,Ping

doi:10.3892/etm.2019.8023

Clinicopathological features and prognostic analysis of 49 cases with crescentic glomerulonephritis

Authors:
- Ting Wu
- Jiajia Peng
- Ting Meng
- Qianqian Liu
- Xiang Ao
- Wei Lin
- Hongling Yin
- Jinbiao Chen
- Jiaxi Pu
- Zhangzhe Peng
- Weisheng Peng
- Xiaozhao Li
- Xiangcheng Xiao
- Qiaoling Zhou
- Yong Zhong
- Ping Xiao
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Affiliations: Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Medical Records and Information, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Published online on: September 18, 2019 https://doi.org/10.3892/etm.2019.8023
Pages: 3984-3990
Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Rapidly progressive glomerulonephritis (RPGN), characterized by rapid kidney dysfunction caused by aggressive glomerulonephritis, is usually associated with crescentic glomerulonephritis (CrGN). In the present study, the data from patients with CrGN were retrospectively analyzed at a tertiary medical center in China with the aim of investigating the clinicopathological features and the association of the type of CrGN with the prognosis. The renal biopsies of 49 patients diagnosed with CrGN were obtained between December 2011 and July 2016. Of the 49 patients, 11 patients (22.45%) had type I CrGN, 19 (38.78%) had type II CrGN and 19 (38.78%) had type III CrGN. The majority of CrGN patients exhibited multiple‑system involvement and 28 patients (57.14%) had kidney enlargement. Proportions of patients with acute kidney injury (AKI), acute kidney diseases without AKI, and chronic kidney disease were 28.57, 46.94 and 24.49%, respectively. Among the 3 types of CrGN, patients with type I CrGN tended to have a higher proportion of AKI with more cellular crescent formation, and higher serum creatinine and retinol binding protein. Circulating anti‑GBM antibodies were present in all type I CrGN patients and anti‑neutrophilic cytoplasmic autoantibodies were detected in 84.21% of patients with type III CrGN. Type III CrGN patients had a superior kidney survival, whereas type I CrGN patients had the worst kidney prognosis (P<0.001). There was no significant difference in overall patient survival among the 3 types of CrGN. CrGN remains the primary cause of critical illness in RPGN patients. There was much heterogeneity between the different subtypes of CrGN. Patients with type I tended to have an acute onset and had the poorest kidney survival.

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