Open Access

Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis

  • Authors:
    • Qianqian Zhou
    • Qian Yu
    • Yu Gong
    • Zhicui Liu
    • Hui Xu
    • Yao Wang
    • Yuling Shi
  • View Affiliations

  • Published online on: September 23, 2019     https://doi.org/10.3892/etm.2019.8035
  • Pages: 4011-4021
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Psoriasis is a chronic inflammatory skin disorder that impairs the quality of life of affected patients. Emerging studies indicate that certain long non‑coding RNAs (lncRNAs) have important roles in psoriasis. However, the exact functions of lncRNAs and their regulatory mechanisms as competitive endogenous RNAs (ceRNAs) in psoriasis have remained to be fully elucidated. In the present study, differentially expressed lncRNAs, microRNAs (miRNAs) and mRNAs were identified by analyzing public datasets, and a psoriasis‑associated lncRNA‑miRNA‑mRNA network was constructed based on the ceRNA theory. Furthermore, previously validated abnormally expressed miRNAs in psoriasis were identified by a systematic literature search in the PubMed and Web of Science databases, and a specific miRNA‑associated lncRNA‑miRNA‑mRNA sub‑network was extracted. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using DAVID 6.8. A total of 253 lncRNAs, 106 miRNAs and 1,156 mRNAs were identified as being differentially expressed between psoriasis skin and healthy control skin. The present study identified two key lncRNAs that may potentially have a role in the pathogenesis of psoriasis: AL035425.3 and Prader Willi/Angelman region RNA 6. This integrative analysis enhances the understanding of the molecular mechanism of psoriasis and may provide novel therapeutic targets for the treatment of psoriasis.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou Q, Yu Q, Gong Y, Liu Z, Xu H, Wang Y and Shi Y: Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis. Exp Ther Med 18: 4011-4021, 2019
APA
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., & Shi, Y. (2019). Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis. Experimental and Therapeutic Medicine, 18, 4011-4021. https://doi.org/10.3892/etm.2019.8035
MLA
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., Shi, Y."Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis". Experimental and Therapeutic Medicine 18.5 (2019): 4011-4021.
Chicago
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., Shi, Y."Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4011-4021. https://doi.org/10.3892/etm.2019.8035