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Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis

  • Authors:
    • Qianqian Zhou
    • Qian Yu
    • Yu Gong
    • Zhicui Liu
    • Hui Xu
    • Yao Wang
    • Yuling Shi
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4011-4021
    |
    Published online on: September 23, 2019
       https://doi.org/10.3892/etm.2019.8035
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Abstract

Psoriasis is a chronic inflammatory skin disorder that impairs the quality of life of affected patients. Emerging studies indicate that certain long non‑coding RNAs (lncRNAs) have important roles in psoriasis. However, the exact functions of lncRNAs and their regulatory mechanisms as competitive endogenous RNAs (ceRNAs) in psoriasis have remained to be fully elucidated. In the present study, differentially expressed lncRNAs, microRNAs (miRNAs) and mRNAs were identified by analyzing public datasets, and a psoriasis‑associated lncRNA‑miRNA‑mRNA network was constructed based on the ceRNA theory. Furthermore, previously validated abnormally expressed miRNAs in psoriasis were identified by a systematic literature search in the PubMed and Web of Science databases, and a specific miRNA‑associated lncRNA‑miRNA‑mRNA sub‑network was extracted. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using DAVID 6.8. A total of 253 lncRNAs, 106 miRNAs and 1,156 mRNAs were identified as being differentially expressed between psoriasis skin and healthy control skin. The present study identified two key lncRNAs that may potentially have a role in the pathogenesis of psoriasis: AL035425.3 and Prader Willi/Angelman region RNA 6. This integrative analysis enhances the understanding of the molecular mechanism of psoriasis and may provide novel therapeutic targets for the treatment of psoriasis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou Q, Yu Q, Gong Y, Liu Z, Xu H, Wang Y and Shi Y: Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis. Exp Ther Med 18: 4011-4021, 2019.
APA
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., & Shi, Y. (2019). Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis. Experimental and Therapeutic Medicine, 18, 4011-4021. https://doi.org/10.3892/etm.2019.8035
MLA
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., Shi, Y."Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis". Experimental and Therapeutic Medicine 18.5 (2019): 4011-4021.
Chicago
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., Shi, Y."Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4011-4021. https://doi.org/10.3892/etm.2019.8035
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Q, Yu Q, Gong Y, Liu Z, Xu H, Wang Y and Shi Y: Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis. Exp Ther Med 18: 4011-4021, 2019.
APA
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., & Shi, Y. (2019). Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis. Experimental and Therapeutic Medicine, 18, 4011-4021. https://doi.org/10.3892/etm.2019.8035
MLA
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., Shi, Y."Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis". Experimental and Therapeutic Medicine 18.5 (2019): 4011-4021.
Chicago
Zhou, Q., Yu, Q., Gong, Y., Liu, Z., Xu, H., Wang, Y., Shi, Y."Construction of a lncRNA‑miRNA‑mRNA network to determine the regulatory roles of lncRNAs in psoriasis". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4011-4021. https://doi.org/10.3892/etm.2019.8035
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