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High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis

  • Authors:
    • Kang Chen
    • Xiaojun Shi
    • Ye Jin
    • Feng Wang
    • Qing Shen
    • Weiming Xu
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 201400, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3943-3947
    |
    Published online on: September 25, 2019
       https://doi.org/10.3892/etm.2019.8049
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Abstract

Long non‑coding RNA (lncRNA) maternally expressed 3 (MEG3) has been reported to be a key component in cancer biology. Preliminary microarray data from a previous study indicated that lncRNA MEG3 expression was altered in plasma of patients with sepsis. The present study found that the plasma levels of lncRNA MEG3 were significantly higher in sepsis patients compared with healthy controls. Patients were subsequently divided into high and low lncRNA MEG3 expression groups according to the Youden's index. Patients from the high lncRNA MEG3 expression group exhibited a significantly higher mortality rate compared with those from the low lncRNA MEG3 expression group. According to treatment outcomes, patients were divided into survival and mortality groups. It was observed that the pre‑therapy expression levels of lncRNA MEG3 were significantly higher in mortality group compared with the survival group. Cell experiments in vitro revealed that lncRNA MEG3 overexpression and silencing using siRNA promoted and inhibited renal epithelial cell and cardiomyocyte apoptosis induced by lipopolysaccharide, respectively. In conclusion, these data suggest that lncRNA MEG3 overexpression may be involved in sepsis, and the downregulation of lncRNA MEG3 may serve as a potential therapeutic target for sepsis.
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Copy and paste a formatted citation
Spandidos Publications style
Chen K, Shi X, Jin Y, Wang F, Shen Q and Xu W: High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis. Exp Ther Med 18: 3943-3947, 2019.
APA
Chen, K., Shi, X., Jin, Y., Wang, F., Shen, Q., & Xu, W. (2019). High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis. Experimental and Therapeutic Medicine, 18, 3943-3947. https://doi.org/10.3892/etm.2019.8049
MLA
Chen, K., Shi, X., Jin, Y., Wang, F., Shen, Q., Xu, W."High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis". Experimental and Therapeutic Medicine 18.5 (2019): 3943-3947.
Chicago
Chen, K., Shi, X., Jin, Y., Wang, F., Shen, Q., Xu, W."High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3943-3947. https://doi.org/10.3892/etm.2019.8049
Copy and paste a formatted citation
x
Spandidos Publications style
Chen K, Shi X, Jin Y, Wang F, Shen Q and Xu W: High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis. Exp Ther Med 18: 3943-3947, 2019.
APA
Chen, K., Shi, X., Jin, Y., Wang, F., Shen, Q., & Xu, W. (2019). High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis. Experimental and Therapeutic Medicine, 18, 3943-3947. https://doi.org/10.3892/etm.2019.8049
MLA
Chen, K., Shi, X., Jin, Y., Wang, F., Shen, Q., Xu, W."High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis". Experimental and Therapeutic Medicine 18.5 (2019): 3943-3947.
Chicago
Chen, K., Shi, X., Jin, Y., Wang, F., Shen, Q., Xu, W."High lncRNA MEG3 expression is associated with high mortality rates in patients with sepsis and increased lipopolysaccharide‑induced renal epithelial cell and cardiomyocyte apoptosis". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3943-3947. https://doi.org/10.3892/etm.2019.8049
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