Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression

  • Authors:
    • Jianan Chen
    • Xingsheng Gu
    • Li Zhou
    • Shuguang Wang
    • Limei Zhu
    • Yangneng Huang
    • Feng Cao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Intensive Care Unit, Ningbo 6th Hospital, Ningbo, Zhejiang 315040, P.R. China, Department of Emergency, Ningbo 6th Hospital, Ningbo, Zhejiang 315040, P.R. China, Department of Trauma Orthopedics, Ningbo 6th Hospital, Ningbo, Zhejiang 315040, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3959-3967
    |
    Published online on: September 27, 2019
       https://doi.org/10.3892/etm.2019.8063
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sepsis remains the primary cause of death in intensive care units and multiple long non‑coding RNAs (lncRNAs) have been demonstrated to be dysregulated in samples of patients with sepsis. However, whether lncRNA‑HOTAIR is involved in the etiology of sepsis remains unclear. The aim of the present study was to investigate the role of HOTAIR in sepsis and to reveal the associated mechanisms. A bioinformatics analysis and dual‑luciferase reporter assay was performed to evaluate the interaction between HOTAIR and miR‑211, as well as miR‑211 and IL‑6R. An animal model of sepsis was established in mice via cecal ligation and puncture. Interferon (IFN)‑γ, interleukin (IL)‑6, IL‑17, tumor necrosis factor (TNF)‑α, IL‑1β, IL‑6 receptor (R), microRNA (miR)‑211 and HOTAIR expression was measured using reverse transcription‑quantitative PCR. Cellular proliferation and apoptosis of monocytes were assessed using cell counting kit‑8 assay and flow cytometry, respectively. miR‑211 was revealed to be targeted by HOTAIR and IL‑6R. The expression of IFN‑γ, IL‑6, IL‑17, TNF‑α, IL‑1β, IL‑6R and HOTAIR was significantly upregulated in the septic mice, whereas miR‑211 expression was downregulated. The overexpression of hox transcript antisense RNA (HOTAIR) and knockdown of miR‑211 were associated with an increased expression of IFN‑γ, IL‑6, IL‑17, TNF‑α, IL‑1β and IL‑6R in monocytes, while the overexpression of miR‑211 exhibited the opposite effect. HOTAIR overexpression and miR‑211 knockdown significantly inhibited cellular proliferation and promoted monocyte apoptosis, whereas the overexpression of miR‑211 exhibited the opposite effects in monocytes. Therefore, HOTAIR may promote the progression of sepsis by indirectly regulating the expression of IL‑6R via miR‑211.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Sagy M, Al-Qaqaa Y and Kim P: Definitions and pathophysiology of sepsis. Curr Probl Pediatr Adolesc Health Care. 43:260–263. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Mohamed AKS, Mehta AA and James P: Predictors of mortality of severe sepsis among adult patients in the medical Intensive Care Unit. Lung India. 34:330–335. 2017. View Article : Google Scholar : PubMed/NCBI

3 

van Vught LA, Wiewel MA, Hoogendijk AJ, Frencken JF, Scicluna BP, Klein Klouwenberg PMC, Zwinderman AH, Lutter R, Horn J, Schultz MJ, et al: The host response in sepsis patients developing intensive care unit-acquired secondary Infections. Am J Respir Crit Care Med. 196:458–470. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Sánchez B, Ferrer R, Suarez D, Romay E, Piacentini E, Gomà G, Martínez ML and Artigas A; Edusepsis Study Group, : Declining mortality due to severe sepsis and septic shock in Spanish intensive care units: A two-cohort study in 2005 and 2011. Med Intensiva. 41:28–37. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Hotchkiss RS, Coopersmith CM, McDunn JE and Ferguson TA: The sepsis seesaw: Tilting toward immunosuppression. Nat Med. 15:496–497. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Jiang W, Zhong W, Deng Y, Chen C, Wang Q, Zhou M, Li X, Sun C and Zeng H: Evaluation of a combination ‘lymphocyte apoptosis model’ to predict survival of sepsis patients in an intensive care unit. BMC Anesthesiol. 18:892018. View Article : Google Scholar : PubMed/NCBI

7 

Gill SE, Rohan M and Mehta S: Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo. Respir Res. 16:1092015. View Article : Google Scholar : PubMed/NCBI

8 

Pool R, Gomez H and Kellum JA: Mechanisms of organ dysfunction in sepsis. Crit Care Clin. 34:63–80. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Halimulati M, Duman B, Nijiati J and Aizezi A: Long noncoding RNA TCONS_00024652 regulates vascular endothelial cell proliferation and angiogenesis via microRNA 21. Exp Ther Med. 16:3309–3316. 2018.PubMed/NCBI

10 

Li TT, He RQ, Ma J, Li ZY, Hu XH and Chen G: Long non-coding RNAs in small cell lung cancer: A potential opening to combat the disease (Review). Oncol Rep. 40:1831–1842. 2018.PubMed/NCBI

11 

Ling Z, Liu D, Zhang G, Liang Q, Xiang P, Xu Y, Han C and Tao T: miR-361-5p modulates metabolism and autophagy via the Sp1-mediated regulation of PKM2 in prostate cancer. Oncol Rep. 38:1621–1628. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Ni X, Liao Y, Li L, Zhang X and Wu Z: Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/β-catenin signaling pathway. J Integr Neurosci. 17:125–132. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Zhang TN, Li D, Xia J, Wu QJ, Wen R, Yang N and Liu CF: Non-coding RNA: A potential biomarker and therapeutic target for sepsis. Oncotarget. 8:91765–91778. 2017.PubMed/NCBI

14 

Diamantopoulos MA, Tsiakanikas P and Scorilas A: Non-coding RNAs: The riddle of the transcriptome and their perspectives in cancer. Ann Transl Med. 6:2412018. View Article : Google Scholar : PubMed/NCBI

15 

Gibbons A, Udawela M and Dean B: Non-coding RNA as novel players in the pathophysiology of schizophrenia. Noncoding RNA. 4(pii): E112018.PubMed/NCBI

16 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

17 

O'Connell RM, Rao DS and Baltimore D: microRNA regulation of inflammatory responses. Annu Rev Immunol. 30:295–312. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Schoof CR, Botelho EL, Izzotti A and Vasques Ldos R: MicroRNAs in cancer treatment and prognosis. Am J Cancer Res. 2:414–433. 2012.PubMed/NCBI

19 

Qiu L, Tan EK and Zeng L: microRNAs and neurodegenerative diseases. Adv Exp Med Biol. 888:85–105. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Kondo Y, Shinjo K and Katsushima K: Long non-coding RNAs as an epigenetic regulator in human cancers. Cancer Sci. 108:1927–1933. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Uchida S and Dimmeler S: Long noncoding RNAs in cardiovascular diseases. Circ Res. 116:737–750. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Tang Y, Zhou T, Yu X, Xue Z and Shen N: The role of long non-coding RNAs in rheumatic diseases. Nat Rev Rheumatol. 13:657–669. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Rong D, Sun H, Li Z, Liu S, Dong C, Fu K, Tang W and Cao H: An emerging function of circRNA-miRNAs-mRNA axis in human diseases. Oncotarget. 8:73271–73281. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Loewen G, Jayawickramarajah J, Zhuo Y and Shan B: Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol. 7:902014. View Article : Google Scholar : PubMed/NCBI

26 

Ling Z, Wang X, Tao T, Zhang L, Guan H, You Z, Lu K, Zhang G, Chen S, Wu J, et al: Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer. J Exp Clin Cancer Res. 36:1592017. View Article : Google Scholar : PubMed/NCBI

27 

Liu XH, Sun M, Nie FQ, Ge YB, Zhang EB, Yin DD, Kong R, Xia R, Lu KH, Li JH, et al: Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer. 13:922014. View Article : Google Scholar : PubMed/NCBI

28 

Lu X, Liu Z, Ning X, Huang L and Jiang B: The long noncoding RNA HOTAIR promotes colorectal cancer progression by sponging miR-197. Oncol Res. 26:473–481. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Wu H, Liu J, Li W, Liu G and Li Z: LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activating NF-κB pathway. Biochem Biophys Res Commun. 471:240–246. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Bosmann M and Ward PA: The inflammatory response in sepsis. Trends Immunol. 34:129–136. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Walborn A, Hoppensteadt D, Syed D, Mosier M and Fareed J: Biomarker profile of sepsis-associated coagulopathy using biochip assay for inflammatory cytokines. Clin Appl Thromb Hemost. 24:625–632. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Schulte W, Bernhagen J and Bucala R: Cytokines in sepsis: Potent immunoregulators and potential therapeutic targets-an updated view. Mediators Inflam. 2013:1659742013. View Article : Google Scholar

33 

Shao WX, Yu DJ, Zhang WY and Wang XJ: Clinical significance of IL-6 in the diagnosis of sepsis and discriminating sepsis induced by gram-negative bacteria. Pediatr Infect Dis J. 37:801–805. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Zhang W and He J: Interleukin-6 is a key factor for immunoglobulin-like transcript-4-mediated immune injury in sepsis. J Intensive Care. 6:222018. View Article : Google Scholar : PubMed/NCBI

35 

Chen Y, Lin MC, Yao H, Wang H, Zhang AQ, Yu J, Hui CK, Lau GK, He ML, Sung J and Kung HF: Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. Hepatology. 46:200–208. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Jiang L, Lai YK, Zhang J, Wang H, Lin MC, He ML and Kung HF: Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis. Mol Med. 17:709–716. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Liu S, Li JH, Wu J, Zhou KR, Zhou H, Yang JH and Qu LH: StarScan: A web server for scanning small RNA targets from degradome sequencing data. Nucleic Acids Res. 43:W480–W486. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Yang JH, Li JH, Shao P, Zhou H, Chen YQ and Qu LH: starBase: A database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res 39 (Database Issue). D202–D209. 2011. View Article : Google Scholar

40 

Wong N and Wang X: miRDB: An online resource for microRNA target prediction and functional annotations. Nucleic Acids Res 43 (Database Issue). D146–D152. 2015. View Article : Google Scholar

41 

Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E and Chang HY: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1323. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Bhan A and Mandal SS: LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. Biochim Biophys Acta. 1856:151–164. 2015.PubMed/NCBI

43 

Hu ML, Wang XY and Chen WM: TGF-β1 upregulates the expression of lncRNA UCA1 and its downstream HXK2 to promote the growth of hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 22:4846–4854. 2018.PubMed/NCBI

44 

Perrot-Applanat M, Kolf-Clauw M, Michel C and Beausoleil C: Alteration of mammary gland development by bisphenol a and evidence of a mode of action mediated through endocrine disruption. Mol Cell Endocrinol. 475:29–53. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Han L, Zhang HC, Li L, Li CX, Di X and Qu X: Downregulation of long noncoding RNA HOTAIR and EZH2 induces apoptosis and inhibits proliferation, invasion, and migration of human breast cancer cells. Cancer Biother Radiopharm. 33:241–251. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Huang J, Ke P, Guo L, Wang W, Tan H, Liang Y and Yao S: Lentivirus-mediated RNA interference targeting the long noncoding RNA HOTAIR inhibits proliferation and invasion of endometrial carcinoma cells in vitro and in vivo. Int J Gynecol Cancer. 24:635–642. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Yuki K and Murakami N: Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets. 15:57–69. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Bone RC, Grodzin CJ and Balk RA: Sepsis: A new hypothesis for pathogenesis of the disease process. Chest. 112:235–243. 1997. View Article : Google Scholar : PubMed/NCBI

49 

Ge L, Hu Q, Chen J, Shi M, Yang H and Zhu G: Inhibition of TNF-α sepsis of lipopolysaccharide induction using nano cerium oxide system. Mater Sci Eng C Mater Biol Appl. 77:405–410. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Zhang Y, Cui X, Ning L and Wei D: The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk. Oncotarget. 8:111456–111469. 2017.PubMed/NCBI

51 

Gao H, Liu L, Zhao Y, Hara H, Chen P, Xu J, Tang J, Wei L, Li Z, Cooper DKC, et al: Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor and swine leukocyte antigen class I in porcine aortic endothelial cells. Xenotransplantation. 24:2017. View Article : Google Scholar

52 

Feng S, Yu H, Yu Y, Geng Y, Li D, Yang C, Lv Q, Lu L, Liu T, Li G and Yuan L: Levels of inflammatory cytokines IL-1β, IL-6, IL-8, IL-17A, and TNF-α in aqueous humour of patients with diabetic retinopathy. J Diabetes Res. 2018:85464232018. View Article : Google Scholar : PubMed/NCBI

53 

McGuire TR, Reardon NT, Bogard K, Plumb TJ, Bultsma CJ, Nissen SW, Fuller PD and Olsen KM: IL6 plasma concentrations in patients with sepsis receiving SLED and antibiotics: A predictor for survival. In Vivo. 28:1131–1134. 2014.PubMed/NCBI

54 

Philip AM, Wang Y, Mauro A, El-Rass S, Marshall JC, Lee WL, Slutsky AS, dosSantos CC and Wen XY: Development of a zebrafish sepsis model for high-throughput drug discovery. Mol Med. 23:134–148. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Shen L, Sun Z, Zhao F, Wang W, Zhang W and Zhu H: Expression of c-FLIP in a rat model of sepsis and its effects on endothelial apoptosis. Mol Med Rep. 16:231–237. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Buras JA, Holzmann B and Sitkovsky M: Animal models of sepsis: Setting the stage. 4:854–865. 2005.PubMed/NCBI

57 

Rittirsch D, Hoesel LM and Ward PA: The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol. 81:137–143. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Chang R, Holcomb JB, Johansson PI, Pati S, Schreiber MA and Wade CE: Plasma resuscitation improved survival in a cecal ligation and puncture rat model of sepsis. Shock. 49:53–61. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Oberbaum M, Spira RM, Lukasiewicz E, Armon Y, Samuels N, Singer SR, Barak V, Izbicki G, Einav S and Hersch M: Effect of Traumeel S on cytokine profile in a cecal ligation and puncture (CLP) sepsis model in rats. J Altern Complement Med. 17:909–913. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Zhang J, Bi J, Liu S, Pang Q, Zhang R, Wang S and Liu C: 5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice. Mediators Inflamm. 2017:63742832017. View Article : Google Scholar : PubMed/NCBI

61 

Sakai M, Suzuki T, Tomita K, Yamashita S, Palikhe S, Hattori K, Yoshimura N, Matsuda N and Hattori Y: Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: Attribution to phosphodiesterase 4 upregulation. Am J Physiol Heart Circ Physiol. 312:H1224–H1237. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Iskander KN, Craciun FL, Stepien DM, Duffy ER, Kim J, Moitra R, Vaickus LJ, Osuchowski MF and Remick DG: Cecal ligation and puncture-induced murine sepsis does not cause lung injury. Crit Care Med. 41:159–170. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Jiang ZJ, Zhang MY, Fan ZW, Sun WL and Tang Y: Influence of lncRNA HOTAIR on acute kidney injury in sepsis rats through regulating miR-34a/Bcl-2 pathway. Eur Rev Med Pharmacol Sci. 23:3512–3519. 2019.PubMed/NCBI

64 

Chen H, Wang X, Yan X, Cheng X, He X and Zheng W: LncRNA MALAT1 regulates sepsis-induced cardiac inflammation and dysfunction via interaction with miR-125b and p38 MAPK/NFκB. Int Immunopharmacol. 55:69–76. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Huang W, Lan X, Li X, Wang D, Sun Y, Wang Q, Gao H and Yu K: Long non-coding RNA PVT1 promote LPS-induced septic acute kidney injury by regulating TNFα and JNK/NF-κB pathways in HK-2 cells. Int Immunopharmacol. 47:134–140. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen J, Gu X, Zhou L, Wang S, Zhu L, Huang Y and Cao F: Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression. Exp Ther Med 18: 3959-3967, 2019.
APA
Chen, J., Gu, X., Zhou, L., Wang, S., Zhu, L., Huang, Y., & Cao, F. (2019). Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression. Experimental and Therapeutic Medicine, 18, 3959-3967. https://doi.org/10.3892/etm.2019.8063
MLA
Chen, J., Gu, X., Zhou, L., Wang, S., Zhu, L., Huang, Y., Cao, F."Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression". Experimental and Therapeutic Medicine 18.5 (2019): 3959-3967.
Chicago
Chen, J., Gu, X., Zhou, L., Wang, S., Zhu, L., Huang, Y., Cao, F."Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3959-3967. https://doi.org/10.3892/etm.2019.8063
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Gu X, Zhou L, Wang S, Zhu L, Huang Y and Cao F: Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression. Exp Ther Med 18: 3959-3967, 2019.
APA
Chen, J., Gu, X., Zhou, L., Wang, S., Zhu, L., Huang, Y., & Cao, F. (2019). Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression. Experimental and Therapeutic Medicine, 18, 3959-3967. https://doi.org/10.3892/etm.2019.8063
MLA
Chen, J., Gu, X., Zhou, L., Wang, S., Zhu, L., Huang, Y., Cao, F."Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression". Experimental and Therapeutic Medicine 18.5 (2019): 3959-3967.
Chicago
Chen, J., Gu, X., Zhou, L., Wang, S., Zhu, L., Huang, Y., Cao, F."Long non‑coding RNA‑HOTAIR promotes the progression of sepsis by acting as a sponge of miR‑211 to induce IL‑6R expression". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3959-3967. https://doi.org/10.3892/etm.2019.8063
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team