Adjunctive vitamin D for the treatment of active juvenile idiopathic arthritis: An open‑label, prospective, randomized controlled trial

Tang,Tao; Zhang,Yu; Luo,Chong; Liu,Mingyue; Xu,Li; Tang,Xuemei

doi:10.3892/etm.2019.8133

Adjunctive vitamin D for the treatment of active juvenile idiopathic arthritis: An open‑label, prospective, randomized controlled trial

Authors:
- Tao Tang
- Yu Zhang
- Chong Luo
- Mingyue Liu
- Li Xu
- Xuemei Tang
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Affiliations: Rheumatology and Immunology Department, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China
Published online on: October 25, 2019 https://doi.org/10.3892/etm.2019.8133
Pages: 4921-4926

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Abstract

Vitamin D has an important immunomodulatory effect, but no trial has examined the effect of boosting serum levels of 25‑hydroxyvitamin D (25OHD) in individuals with juvenile idiopathic arthritis (JIA). The aim of the present study was to assess whether vitamin D supplementation reduced disease activity and adjusted/maintained bone mass in patients with active JIA. A 24‑week randomized trial was undertaken at Children's Hospital of Chongqing Medical University. Treatment‑naive patients with JIA were randomly assigned (1:1) to one of two groups: Standard treatment with high dose oral cholecalciferol [2,000 IU per day; experimental group (EG)] or without supplementation [control group (CG)]. The primary outcomes were the 27‑joint Juvenile Arthritis Disease Activity Score (JADAS‑27 score), the Z‑score for bone mineral density (BMD), and serum levels of 25OHD. A per‑protocol analysis set approach was used. The Mann‑Whitney U test was the main tool used for data analysis. A total of 42 participants were assigned randomly to the EG (n=20) or the CG (n=22); of these, 36 (n=18 and n=18, respectively) were included in per‑protocol analysis. After 24 weeks, the mean level of 25OHD in the EG was higher than that in the CG (P<0.05). At the end of the intervention, there were no clear differences between the two groups in terms of BMD or JADAS‑27 score (both P>0.05). Cholecalciferol supplementation (2000 IU/day) for 24 weeks raised serum levels of 25OHD in JIA patients but did not reduce disease activity or improve BMD (registration no. ChiCTR‑INR‑16009235; Date of Registration: 2016‑10‑12).

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