Open Access

Effect of neuromedin U on allergic airway inflammation in an asthma model (Review)

  • Authors:
    • Xiaojie Ren
    • Fang Dong
    • Yuerong Zhuang
    • Yong Wang
    • Wuhua Ma
  • View Affiliations

  • Published online on: December 4, 2019     https://doi.org/10.3892/etm.2019.8283
  • Pages: 809-816
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called ‘The Global Burden of Asthma’ in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU) plays a pleiotropic role in the pathogenesis of asthma. NMU is a highly structurally conserved neuropeptide that was first purified from porcine spinal cord and named for its contractile effect on the rat uterus. NMU amplifies type 2 innate lymphoid cell (ILC2)‑driven allergic lung inflammation. The NMU receptors (NMURs), designated as NMUR1 and NMUR2, belong to the G protein‑coupled receptor family. NMUR1 has also been found in immune cells, including ILC2s, mast cells and eosinophils. In view of the important roles of NMU in the pathogenesis of asthma, the present review evaluates the potential mechanisms underlying the impact of NMU on asthma and its association with asthma therapy.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Ren X, Dong F, Zhuang Y, Wang Y and Ma W: Effect of neuromedin U on allergic airway inflammation in an asthma model (Review). Exp Ther Med 19: 809-816, 2020
APA
Ren, X., Dong, F., Zhuang, Y., Wang, Y., & Ma, W. (2020). Effect of neuromedin U on allergic airway inflammation in an asthma model (Review). Experimental and Therapeutic Medicine, 19, 809-816. https://doi.org/10.3892/etm.2019.8283
MLA
Ren, X., Dong, F., Zhuang, Y., Wang, Y., Ma, W."Effect of neuromedin U on allergic airway inflammation in an asthma model (Review)". Experimental and Therapeutic Medicine 19.2 (2020): 809-816.
Chicago
Ren, X., Dong, F., Zhuang, Y., Wang, Y., Ma, W."Effect of neuromedin U on allergic airway inflammation in an asthma model (Review)". Experimental and Therapeutic Medicine 19, no. 2 (2020): 809-816. https://doi.org/10.3892/etm.2019.8283