Open Access

Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis

  • Authors:
    • Hongling Zhu
    • Lianyong Liu
    • Li Ren
    • Junhua Ma
    • Shuanggang Hu
    • Zhaohui Zhu
    • Xuemei Zhao
    • Chao Shi
    • Xing Wang
    • Chaobao Zhang
    • Mingjun Gu
    • Xiangqi Li
  • View Affiliations

  • Published online on: December 31, 2019     https://doi.org/10.3892/etm.2019.8397
  • Pages: 1733-1738
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Type 2 taste receptor 10 (TAS2R10), belonging to the TAS2R family of bitter receptors, is widely expressed in extra‑oral tissues. However, its biological roles beyond bitterness sensing in the tongue have remained largely elusive. The present study aimed to perform a positive co‑expression analysis using 60,000 Affymetrix expression arrays and 5,000 The Cancer Genome Atlas datasets to uncover such roles. Based on the functional enrichment analysis, it was indicated that in the Gene Ontology (GO) category biological process, TAS2R10 was mostly involved in ‘cellular protein metabolic process’, ‘protein modification process’, ‘cellular protein modification process’ and ‘cellular component assembly’. In the GO category cellular component, the co‑expressed genes were accumulated in ‘Spt‑Ada‑Gcn5 acetyltransferase (SAGA)‑type complex’ and ‘SAGA complex’, and in the category molecular function, they were concentrated in ‘hexosaminidase activity’, ‘cytoskeletal adaptor activity’, ‘cyclin binding’ and ‘β‑N‑acetylhexosaminidase activity’. Of note, it was indicated that TAS2R10 may be involved in ‘ubiquitin‑mediated proteolysis’, which may provide a starting point to fully investigate the detailed functions of TAS2R10 in the future. TAS2R10 was also indicated to be associated with human diseases, i.e. ‘Salmonella infection’. Overall, the present study was the first to perform a comprehensive bioinformatics analysis of the functions of TAS2R10 and provide insight regarding the notion that this gene may have crucial roles beyond bitterness sensing.

Related Articles

Journal Cover

March 2020
Volume 19 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Zhu, H., Liu, L., Ren, L., Ma, J., Hu, S., Zhu, Z. ... Li, X. (2020). Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis. Experimental and Therapeutic Medicine, 19, 1733-1738. https://doi.org/10.3892/etm.2019.8397
MLA
Zhu, H., Liu, L., Ren, L., Ma, J., Hu, S., Zhu, Z., Zhao, X., Shi, C., Wang, X., Zhang, C., Gu, M., Li, X."Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis". Experimental and Therapeutic Medicine 19.3 (2020): 1733-1738.
Chicago
Zhu, H., Liu, L., Ren, L., Ma, J., Hu, S., Zhu, Z., Zhao, X., Shi, C., Wang, X., Zhang, C., Gu, M., Li, X."Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis". Experimental and Therapeutic Medicine 19, no. 3 (2020): 1733-1738. https://doi.org/10.3892/etm.2019.8397