Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis

Zhu,Hongling; Liu,Lianyong; Ren,Li; Ma,Junhua; Hu,Shuanggang; Zhu,Zhaohui; Zhao,Xuemei; Shi,Chao; Wang,Xing; Zhang,Chaobao; Gu,Mingjun; Li,Xiangqi

doi:10.3892/etm.2019.8397

March-2020 Volume 19 Issue 3

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March-2020 Volume 19 Issue 3

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Article Open Access

Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis

Authors:
- Hongling Zhu
- Lianyong Liu
- Li Ren
- Junhua Ma
- Shuanggang Hu
- Zhaohui Zhu
- Xuemei Zhao
- Chao Shi
- Xing Wang
- Chaobao Zhang
- Mingjun Gu
- Xiangqi Li
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Affiliations: Department of Endocrinology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai 200135, P.R. China, Department of Endocrinology, Punan Hospital of Pudong New District, Shanghai 200125, P.R. China, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, P.R. China, State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P.R. China

Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1733-1738
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Published online on: December 31, 2019

https://doi.org/10.3892/etm.2019.8397
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Abstract

Type 2 taste receptor 10 (TAS2R10), belonging to the TAS2R family of bitter receptors, is widely expressed in extra‑oral tissues. However, its biological roles beyond bitterness sensing in the tongue have remained largely elusive. The present study aimed to perform a positive co‑expression analysis using 60,000 Affymetrix expression arrays and 5,000 The Cancer Genome Atlas datasets to uncover such roles. Based on the functional enrichment analysis, it was indicated that in the Gene Ontology (GO) category biological process, TAS2R10 was mostly involved in ‘cellular protein metabolic process’, ‘protein modification process’, ‘cellular protein modification process’ and ‘cellular component assembly’. In the GO category cellular component, the co‑expressed genes were accumulated in ‘Spt‑Ada‑Gcn5 acetyltransferase (SAGA)‑type complex’ and ‘SAGA complex’, and in the category molecular function, they were concentrated in ‘hexosaminidase activity’, ‘cytoskeletal adaptor activity’, ‘cyclin binding’ and ‘β‑N‑acetylhexosaminidase activity’. Of note, it was indicated that TAS2R10 may be involved in ‘ubiquitin‑mediated proteolysis’, which may provide a starting point to fully investigate the detailed functions of TAS2R10 in the future. TAS2R10 was also indicated to be associated with human diseases, i.e. ‘Salmonella infection’. Overall, the present study was the first to perform a comprehensive bioinformatics analysis of the functions of TAS2R10 and provide insight regarding the notion that this gene may have crucial roles beyond bitterness sensing.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis

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