IgY ‑ turning the page toward passive immunization in COVID-19 infection (Review)

Constantin,Carolina; Neagu,Monica; Supeanu,Teodora Diana; Chiurciu,Viorica; Spandidos,Demetrios A.

doi:10.3892/etm.2020.8704

July-2020 Volume 20 Issue 1

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July-2020 Volume 20 Issue 1

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Review Open Access

IgY ‑ turning the page toward passive immunization in COVID-19 infection (Review)

Authors:
- Carolina Constantin
- Monica Neagu
- Teodora Diana Supeanu
- Viorica Chiurciu
- Demetrios A. Spandidos
View Affiliations / Copyright

Affiliations: Immunology Laboratory, ‘Victor Babes’ National Institute of Pathology, 050096 Bucharest, Romania, Romvac Company S.A., 077190 Voluntari, Romania, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece

Copyright: © Constantin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 151-158
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Published online on: April 30, 2020

https://doi.org/10.3892/etm.2020.8704
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Abstract

The world is facing one of the major outbreaks of viral infection of the modern history, however, as vaccine development workflow is still tedious and can not control the infection spreading, researchers are turning to passive immunization as a good and quick alternative to treat and contain the spreading. Within passive immunization domain, raising specific immunoglobulin (Ig)Y against acute respiratory tract infection has been developing for more than 20 years. Far from being an obsolete chapter we will revise the IgY‑technology as a new frontier for research and clinic. A wide range of IgY applications has been effectively confirmed in both human and animal health. The molecular particularities of IgY give them functional advantages recommending them as good candidates in this endeavor. Obtaining specific IgY is sustained by reliable and nature friendly methodology as an alternative for mammalian antibodies. The aria of application is continuously enlarging from bacterial and viral infections to tumor biology. Specific anti‑viral IgY were previously tested in several designs, thus its worth pointing out that in the actual COVID-19 pandemic context, respiratory infections need an enlarged arsenal of therapeutic approaches and clearly the roles of IgY should be exploited in depth.

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