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Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity

  • Authors:
    • Bangqin Wang
    • Xinxiang Huang
    • Jinying Lin
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 910-916
    |
    Published online on: May 21, 2020
       https://doi.org/10.3892/etm.2020.8779
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Abstract

Expression levels of serum cyclooxygenase (COX)-2 and forkhead box O3a (FOXO3a) in patients with rheumatoid arthritis (RA) and the correlation with disease activity were investigated. Sixty patients with RA admitted to the People's Hospital of Guangxi Zhuang Autonomous Region (study group; 28 active patients and 32 remissive patients), and further 30 healthy subjects undergoing physical examinations during the same period (control group) were enrolled in this study. RT‑qPCR and enzyme‑linked immunosorbent assay (ELISA) were used to detect the expression levels of COX‑2 and FOXO3a in serum. According to DAS28 score, the patients were divided into active and remissive patients, between whom the expression levels were compared. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic values of COX‑2 and FOXO3a for disease activity. Pearson's correlation coefficient was used to analyze the correlation of the two markers with erythrocyte sedimentation rate (ESR), C‑reactive protein (CRP), and DAS28 score. The expression levels of COX‑2 and FOXO3a in active and remissive patients were significantly higher than those in the control group (both P<0.05), and those in active patients were significantly higher than those in remissive patients (both P<0.05). The areas under the ROC curves (AUCs) of COX‑2 and FOXO3a were 0.748 and 0.802, respectively, suggesting that the two markers have high diagnostic value. The expression levels of COX‑2 and FOXO3a were positively correlated with ESR, CRP, and DAS28 score of active and remissive patients (both P<0.05). In conclusion, the expression levels of COX‑2 and FOXO3a in patients with RA are upregulated, thus, the two markers may be involved in the development and progression of the disease. The expression levels of COX‑2 and FOXO3a are related to the disease activity of RA, and therefore can be used as diagnostic indicators for the disease activity.
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1 

Singh JA, Saag KG, Bridges SL Jr, Akl EA, Bannuru RR, Sullivan MC, Vaysbrot E, McNaughton C, Osani M, Shmerling RH, et al: 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Rheumatol. 68:1–26. 2016.PubMed/NCBI View Article : Google Scholar

2 

Jin S, Li M, Fang Y, Li Q, Liu J, Duan X, Liu Y, Wu R, Shi X, Wang Y, et al: CREDIT Co-authors: Chinese Registry of rheumatoid arthritis (CREDIT): II prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis. Arthritis Res Ther. 19(251)2017.PubMed/NCBI View Article : Google Scholar

3 

de Achaval S and Suarez-Almazor ME: Treatment adherence to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis and systemic lupus erythematosus. Int J Clin Rheumatol. 5:313–326. 2010.PubMed/NCBI View Article : Google Scholar

4 

Malmström V, Catrina AI and Klareskog L: The immunopathogenesis of seropositive rheumatoid arthritis: From triggering to targeting. Nat Rev Immunol. 17:60–75. 2017.PubMed/NCBI View Article : Google Scholar

5 

Catrina AI, Joshua V, Klareskog L and Malmström V: Mechanisms involved in triggering rheumatoid arthritis. Immunol Rev. 269:162–174. 2016.PubMed/NCBI View Article : Google Scholar

6 

Zelenay S, van der Veen AG, Böttcher JP, Snelgrove KJ, Rogers N, Acton SE, Chakravarty P, Girotti MR, Marais R, Quezada SA, et al: Cyclooxygenase-dependent tumor growth through evasion of immunity. Cell. 162:1257–1270. 2015.PubMed/NCBI View Article : Google Scholar

7 

Depboylu C, Weihe E and Eiden LE: COX1 and COX2 expression in non-neuronal cellular compartments of the rhesus macaque brain during lentiviral infection. Neurobiol Dis. 42:108–115. 2011.PubMed/NCBI View Article : Google Scholar

8 

Yang CM, Chen YW, Chi PL, Lin CC and Hsiao LD: Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts. Biochem Pharmacol. 132:77–91. 2017.PubMed/NCBI View Article : Google Scholar

9 

Walther U, Emmrich K, Ramer R, Mittag N and Hinz B: Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway. Oncotarget. 7:10345–10362. 2016.PubMed/NCBI View Article : Google Scholar

10 

Lowin T, Apitz M, Anders S and Straub RH: Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. Arthritis Res Ther. 17(321)2015.PubMed/NCBI View Article : Google Scholar

11 

Tang YL, Huang LB, Lin WH, Wang LN, Tian Y, Shi D, Wang J, Qin G, Li A, Liang YN, et al: Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. Oncotarget. 7:18651–18664. 2016.PubMed/NCBI View Article : Google Scholar

12 

Obexer P, Geiger K, Ambros PF, Meister B and Ausserlechner MJ: FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ. 14:534–547. 2007.PubMed/NCBI View Article : Google Scholar

13 

Jiang Y, Zou L, Lu WQ, Zhang Y and Shen AG: Foxo3a expression is a prognostic marker in breast cancer. PLoS One. 8(e70746)2013.PubMed/NCBI View Article : Google Scholar

14 

Viatte S, Lee JC, Fu B, Espéli M, Lunt M, De Wolf JN, Wheeler L, Reynolds JA, Castelino M, Symmons DP, et al: Association between genetic variation in FOXO3 and reductions in inflammation and disease activity in inflammatory polyarthritis. Arthritis Rheumatol. 68:2629–2636. 2016.PubMed/NCBI View Article : Google Scholar

15 

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, et al: 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62:2569–2581. 2010.PubMed/NCBI View Article : Google Scholar

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

17 

Narayan N, Owen DR, Mandhair H, Smyth E, Carlucci F, Saleem A, Gunn RN, Rabiner EA, Wells L, Dakin SG, et al: Translocator protein as an imaging marker of macrophage and stromal activation in rheumatoid arthritis pannus. J Nucl Med. 59:1125–1132. 2018.PubMed/NCBI View Article : Google Scholar

18 

Gong G and Mao J: Health-related quality of life among Chinese patients with rheumatoid arthritis: The predictive roles of fatigue, functional disability, self-efficacy, and social support. Nurs Res. 65:55–67. 2016.PubMed/NCBI View Article : Google Scholar

19 

Smith SR, Deshpande BR, Collins JE, Katz JN and Losina E: Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: Systematic analytic review. Osteoarthritis Cartilage. 24:962–972. 2016.PubMed/NCBI View Article : Google Scholar

20 

Fan HW, Liu GY, Zhao CF, Li XF and Yang XY: Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis. Genet Mol Res. 14:12872–12879. 2015.PubMed/NCBI View Article : Google Scholar

21 

Peng A, Lu X, Huang J, He M, Xu J, Huang H and Chen Q: Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE 2 pathway. Arthritis Res Ther. 21(169)2019.PubMed/NCBI View Article : Google Scholar

22 

Roubille C, Richer V, Starnino T, McCourt C, McFarlane A, Fleming P, Siu S, Kraft J, Lynde C, Pope J, et al: The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: A systematic review and meta-analysis. Ann Rheum Dis. 74:480–489. 2015.PubMed/NCBI View Article : Google Scholar

23 

Nissen SE, Yeomans ND, Solomon DH, Lüscher TF, Libby P, Husni ME, Graham DY, Borer JS, Wisniewski LM, Wolski KE, et al: PRECISION Trial Investigators: Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 375:2519–2529. 2016.PubMed/NCBI View Article : Google Scholar

24 

Codogno P and Morel E: FOXO3a provides a quickstep from autophagy inhibition to apoptosis in cancer therapy. Dev Cell. 44:537–539. 2018.PubMed/NCBI View Article : Google Scholar

25 

Turrel-Davin F, Tournadre A, Pachot A, Arnaud B, Cazalis MA, Mougin B and Miossec P: FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and msynovial tissue. Ann Rheum Dis. 69:755–760. 2010.PubMed/NCBI View Article : Google Scholar

26 

Yoshida K, Matsui K, Nakano H, Oshikawa H, Utsunomiya M, Kobayashi T, Kimura M, Deshpande GA and Kishimoto M: Response to ‘Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: A longitudinal observational study’. Arthritis Res Ther. 13(405)2011.PubMed/NCBI View Article : Google Scholar

27 

Sheehy C, Evans V, Hasthorpe H and Mukhtyar C: Revising DAS28 scores for remission in rheumatoid arthritis. Clin Rheumatol. 33:269–272. 2014.PubMed/NCBI View Article : Google Scholar

28 

Shimada K, Komiya A, Yokogawa N, Nishino J, Sugii S and Tohma S: Impact of the size and number of swollen joints on serum C-reactive protein level and erythrocyte sedimentation rate in rheumatoid arthritis: A cross-sectional study in Japan. Clin Rheumatol. 36:427–431. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang B, Huang X and Lin J: Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity. Exp Ther Med 20: 910-916, 2020.
APA
Wang, B., Huang, X., & Lin, J. (2020). Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity. Experimental and Therapeutic Medicine, 20, 910-916. https://doi.org/10.3892/etm.2020.8779
MLA
Wang, B., Huang, X., Lin, J."Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity". Experimental and Therapeutic Medicine 20.2 (2020): 910-916.
Chicago
Wang, B., Huang, X., Lin, J."Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity". Experimental and Therapeutic Medicine 20, no. 2 (2020): 910-916. https://doi.org/10.3892/etm.2020.8779
Copy and paste a formatted citation
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Spandidos Publications style
Wang B, Huang X and Lin J: Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity. Exp Ther Med 20: 910-916, 2020.
APA
Wang, B., Huang, X., & Lin, J. (2020). Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity. Experimental and Therapeutic Medicine, 20, 910-916. https://doi.org/10.3892/etm.2020.8779
MLA
Wang, B., Huang, X., Lin, J."Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity". Experimental and Therapeutic Medicine 20.2 (2020): 910-916.
Chicago
Wang, B., Huang, X., Lin, J."Serum COX‑2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity". Experimental and Therapeutic Medicine 20, no. 2 (2020): 910-916. https://doi.org/10.3892/etm.2020.8779
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