Open Access

Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury

  • Authors:
    • Jiajun Zhu
    • Yu Fu
    • Guanjun Tu
  • View Affiliations

  • Published online on: June 3, 2020     https://doi.org/10.3892/etm.2020.8832
  • Pages: 1675-1681
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the role of Smad3 inhibitors and the pyroptosis pathway in spinal cord injury, and to determine the underlying mechanism. The pyroptosis signaling pathway may be involved in spinal cord injury during the recovery period. Smad3 inhibitor may serve a role in alleviating spinal cord injury by reducing the pyroptosis of neurons, which is induced by caspase‑1, absent in melanoma‑2 or NOD‑like receptors protein‑1 during the recovery period of spinal cord injury. In the present study, spinal cord injury was alleviated by caspase‑1 and Smad3 inhibitors. Therefore, a Smad3 inhibitor could relieve spinal cord injury in mice by directly downregulating caspase‑1 and reducing neuron pyroptosis following spinal cord injury during the recovery period.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Zhu, J., Fu, Y., & Tu, G. (2020). Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury. Experimental and Therapeutic Medicine, 20, 1675-1681. https://doi.org/10.3892/etm.2020.8832
MLA
Zhu, J., Fu, Y., Tu, G."Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury". Experimental and Therapeutic Medicine 20.2 (2020): 1675-1681.
Chicago
Zhu, J., Fu, Y., Tu, G."Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1675-1681. https://doi.org/10.3892/etm.2020.8832