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Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury

  • Authors:
    • Jiajun Zhu
    • Yu Fu
    • Guanjun Tu
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    Affiliations: Department of Orthopedics, The First Affiliated Hospital of China Medical University, Heping, Shenyang, Liaoning 110000, P.R. China, Department of Clinical Nutrition, Shengjing Hospital of China Medical University, Heping, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1675-1681
    |
    Published online on: June 3, 2020
       https://doi.org/10.3892/etm.2020.8832
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Abstract

The aim of the present study was to investigate the role of Smad3 inhibitors and the pyroptosis pathway in spinal cord injury, and to determine the underlying mechanism. The pyroptosis signaling pathway may be involved in spinal cord injury during the recovery period. Smad3 inhibitor may serve a role in alleviating spinal cord injury by reducing the pyroptosis of neurons, which is induced by caspase‑1, absent in melanoma‑2 or NOD‑like receptors protein‑1 during the recovery period of spinal cord injury. In the present study, spinal cord injury was alleviated by caspase‑1 and Smad3 inhibitors. Therefore, a Smad3 inhibitor could relieve spinal cord injury in mice by directly downregulating caspase‑1 and reducing neuron pyroptosis following spinal cord injury during the recovery period.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Fu Y and Tu G: Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury. Exp Ther Med 20: 1675-1681, 2020.
APA
Zhu, J., Fu, Y., & Tu, G. (2020). Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury. Experimental and Therapeutic Medicine, 20, 1675-1681. https://doi.org/10.3892/etm.2020.8832
MLA
Zhu, J., Fu, Y., Tu, G."Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury". Experimental and Therapeutic Medicine 20.2 (2020): 1675-1681.
Chicago
Zhu, J., Fu, Y., Tu, G."Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1675-1681. https://doi.org/10.3892/etm.2020.8832
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Fu Y and Tu G: Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury. Exp Ther Med 20: 1675-1681, 2020.
APA
Zhu, J., Fu, Y., & Tu, G. (2020). Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury. Experimental and Therapeutic Medicine, 20, 1675-1681. https://doi.org/10.3892/etm.2020.8832
MLA
Zhu, J., Fu, Y., Tu, G."Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury". Experimental and Therapeutic Medicine 20.2 (2020): 1675-1681.
Chicago
Zhu, J., Fu, Y., Tu, G."Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1675-1681. https://doi.org/10.3892/etm.2020.8832
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