Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation

  • Authors:
    • Dawei Wang
    • Xuena Zheng
    • Min Li
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Hematology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Endocrinology and Rheumatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1575-1581
    |
    Published online on: June 5, 2020
       https://doi.org/10.3892/etm.2020.8845
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to assess the correlation between the contrast‑enhanced ultrasound (CEUS) parameters and biological characteristics of papillary thyroid carcinoma (PTC), and identify risk factors of recurrence for the prognosis after radiofrequency ablation. A total of 72 patients with PTC were included. Disease recurrence and metastasis were evaluated based on the imaging performance and laboratory tests. Perfusion parameters were recorded and compared. After biopsy, the tumor tissues were subjected to hematoxylin and eosin staining, and the expression levels of P53 and Ki67 were detected using immunohistochemistry. The association between the CEUS parameters and the expression of P53 and Ki67 was analyzed. Risk factors for disease recurrence were analyzed using logistic regression. Compared with normal tissues, PTC tissue was characterized by a slow perfusion pattern with no obvious enhancement. The peak time and intensity were lower, while the initial increasing time and mean transit time (MTT) were longer in the PTC tissue. The expression levels of P53 and Ki67 in PTC tissues were associated with age, local infiltration, lymph node metastasis and the number of lesions, but not with gender, tumor size, histological type or degree of differentiation. The initial increasing time, peak time and MTT were negatively correlated, while the peak intensity was positively correlated with the expression of P53 and Ki67 in PTC tissues. Multivariate logistic regression analysis suggested that lymph node metastasis, age, local infiltration, peak intensity and MTT were risk factors for disease recurrence. In conclusion, quantitative CEUS parameters are closely linked to the biological characteristics of PTC and may serve as indicators for the prognosis of patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

He C, Zhang J and Xing Y: Research progress in diagnosis and treatment of papillary thyroid carcinoma. Modern Diagnosis Treat. 17:290–292. 2006.(In Chinese).

2 

Fu D, Zhu Y, Shao W, et al: Clinical analysis of 124 cases of papillary microcarcinoma. Chin J Curr Adv Gen Surg. 16:157–158. 2013.(In Chinese).

3 

Sun P and Liang D: Effects of ultrasound-guided radiofrequency ablation and postoperative stress on thyroid micropapillary carcinoma. Chin J Curr Adv Gen Surg. 21:217–222. 2018.

4 

Zhou Q and Jiang Z: Value of Contrast-enhanced ultrasound in diagnosis of thyroid papillary carcinoma. Chin J Ultrasound Med. 27:595–597. 2011.

5 

Wang F, Chen M, Huang Y, Gao Y, Qiu Y, Wang B and Chang C: Ultrasonograpbic characteristics of thyroid carcinoma and analysis of the misdiagnosed cases. Chin J Ultrasonography. 19:134–137. 2010.(In Chinese).

6 

Gao X and Zhang Y, Sun Y and Zhang Y: Clinical efficacy and adverse reaction analysis of laparoscopic surgery for colon; cancer. Chin J Curr Adv Gen Surg. 18:738–740. 2015.(In Chinese).

7 

Liu F, Xia Q, Qiu J, et al: Expression and clinical significance of C-myb and P53 in papillary thyroid carcinoma. J Oncol. 21:320–324. 2015.

8 

Dong L, Peng T, Liu N, Shuang L and Xudong S: Expression and clinical significance of ER, PR and Her2/neu in papillary thyroid carcinoma. J Modern Oncol. 23:3576–3579. 2015.

9 

Jiang WF, Wang YX and Cheng M: Expression and relationship of XIAP, P53 and Ki67 in papillary thyroid carcinoma. Beijing Med J. 34:971–974. 2012.(In Chinese).

10 

Tang X, Cui D, Chi J, Wang Z, Wang T, Zhai B and Li P: Evaluation of the safety and efficacy of radiofrequency ablation for treating benign thyroid nodules. J Cancer. 8:754–760. 2017.PubMed/NCBI View Article : Google Scholar

11 

Zhang L, Dong Y, Hu S, et al: The impact of American Cancer Joint Committee Revised Thyroid Cancer Staging System (8th edition) on staging of papillary thyroid carcinoma. Chin Oncol. 7:491–496. 2018.(In Chinese). PubMed/NCBI View Article : Google Scholar

12 

Song J, Yang Z and Wang HM: Domestic progress in the diagnosis of differentiated thyroid carcinoma. World Latest Med Infor. 18:64–65. 2016.(In Chinese).

13 

Xhaard C, Rubino C, Cléro E, Maillard S, Ren Y, Borson-Chazot F, Sassolas G, Schvartz C, Colonna M, Lacour B, et al: Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in young women in France: A population-based case-control study. Am J Epidemiol. 180:1007–1017. 2014.PubMed/NCBI View Article : Google Scholar

14 

Tafani M, De Santis E, Coppola L, Perrone GA, Carnevale I, Russo A, Pucci B, Carpi A, Bizzarri M and Russo MA: Biodging hypoxin, inflammation and estrogen receptors in the thyroid cancer progression. Biomed Pharmacother. 68:1–5. 2014.PubMed/NCBI View Article : Google Scholar

15 

Chen X and Zhao B: Contrast-enhanced ultrasound in diagnosis and treatment of liver diseases. Chin J Med Imaging Technol. 21:484–487. 2005.

16 

Du L and Li F: Application of contrast-enhanced ultrasound in the diagnosis of renal occupied lesions. Chin J Ultrasonography. 15:813–815. 2006.

17 

Wang L and Yang W: Expression and clinical significance of p53, C-myc and CerbB-2 in papillary thyroid carcinoma. Chongqing Med. 45:77–80. 2016.

18 

Wang YQ and Qiu XG: Expressions of p53, RUNX3 and Ki67 proteins in papillary thyroid carcinoma and clinical significance. Clin Med. 33:3–4. 2013.

19 

de Azambuja E and Cardoso F: Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12, 155 patients. Br J Cancer. 96:1504–1513. 2007.PubMed/NCBI View Article : Google Scholar

20 

Viale G, Regan MM, Mastropasqua MG, Maffini F, Maiorano E, Colleoni M, Price KN, Golouh R, Perin T, Brown RW, et al: Predictive value of tumor Ki-67 expression in two randomized trials of adjuvant chemoendocrine therapy for Node-negative breast cancer. J Natl Cancer Inst. 100:207–212. 2008.PubMed/NCBI View Article : Google Scholar

21 

Yeh CC, Lin JT, Jeng LB, Charalampos I, Chen TT, Lee TY, Wu MS, Kuo KN, Liu YY and Wu CY: Hepatic resection for hepatocellular carcinoma patients on hemodialysis for Uremia: A nationwide cohort study. World J Surg. 37:2402–2409. 2013.PubMed/NCBI View Article : Google Scholar

22 

Argalia G, De Bernardis S, Mariani D, Abbattista T, Taccaliti A, Ricciardelli L, Faragona S, Gusella PM and Giuseppetti GM: Ultrasonographic contrast agent: Evaluation of time-intensity curves in the characterisation of solitary thyroid nodules. Radiol Med. 103:407–13. 2002.(In English, Italian). PubMed/NCBI

23 

Shi X, Zheng X, Guo H, Li C, Peng M, Zhou G, Jiang Y, Yan S and Yu Y: Contrast analysis on contrast-enhanced ultrasonography and pathology of thyroid lumps. Zhejiang Practical Med. 12:87–88. 2007.(In Chinese).

24 

Bartolotta TV, Midiri M, Galia M, Runza G, Attard M, Savoia G, Lagalla R and Cardinale AE: Qualitative and quantitative evaluation of solitary thyroid nodules with contrast-enhanced ultrasound: Initial results. Eur Radiol. 16:2234–2241. 2006.PubMed/NCBI View Article : Google Scholar

25 

Chen Q: Diagnostic value of high frequency ultrasound in benign and malignant thyroid nodules. Chin Imaging J Integrated Traditional Western Med. 10:545–546. 2012.

26 

Zhao L, Lin J, Shi B, et al: Expression of P53, Ki67, galectin-3, HBME-1, 34βE12 and CK19 in papillary thyroid carcinoma and its clinicopathological significance. Basic Clin Med. 32:1202–1206. 2012.

27 

Huang H: Expression of CK19, Ki67 and VEGF and their clinical significances in papillary thyroid carcinoma. J Nanchang Univ (Med Sci). 50:24–27. 2010.

28 

Jia W and Yin C: Expressions of p53, Her-2 and Ki67 in thyroid papillary carcinoma and their clinical significance. China J Modern Med. 28:33–37. 2018.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang D, Zheng X and Li M: Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation. Exp Ther Med 20: 1575-1581, 2020.
APA
Wang, D., Zheng, X., & Li, M. (2020). Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation. Experimental and Therapeutic Medicine, 20, 1575-1581. https://doi.org/10.3892/etm.2020.8845
MLA
Wang, D., Zheng, X., Li, M."Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation". Experimental and Therapeutic Medicine 20.2 (2020): 1575-1581.
Chicago
Wang, D., Zheng, X., Li, M."Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1575-1581. https://doi.org/10.3892/etm.2020.8845
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Zheng X and Li M: Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation. Exp Ther Med 20: 1575-1581, 2020.
APA
Wang, D., Zheng, X., & Li, M. (2020). Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation. Experimental and Therapeutic Medicine, 20, 1575-1581. https://doi.org/10.3892/etm.2020.8845
MLA
Wang, D., Zheng, X., Li, M."Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation". Experimental and Therapeutic Medicine 20.2 (2020): 1575-1581.
Chicago
Wang, D., Zheng, X., Li, M."Correlation analysis between the pre‑operative contrast‑enhanced ultrasound parameters and biological characteristics of papillary thyroid carcinoma and associated risk factors for prognosis after radiofrequency ablation". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1575-1581. https://doi.org/10.3892/etm.2020.8845
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team