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Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia

  • Authors:
    • Shuli Guo
    • Bo Li
    • Xiaoyan Xu
    • Wanli Wang
    • Songyun Wang
    • Tao Lv
    • Huirui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 471009, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1521-1531
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    Published online on: June 5, 2020
       https://doi.org/10.3892/etm.2020.8846
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Abstract

Acute myelocytic leukemia (AML) is a frequent type of acute leukemia. The present study was performed to build a risk score system for the prognostic prediction of AML. AML RNA‑sequencing data from samples from 111 children were downloaded from The Cancer Genome Atlas database. Using the DEseq and edgeR packages, the differentially expressed long non‑coding RNAs (DE‑lncRNAs) between bad and good prognosis groups were identified. A survival package was used to screen prognosis‑associated lncRNAs and clinical factors. The optimal lncRNA combination was selected using the penalized package, and the risk‑score system was built and evaluated. After the lncRNA‑mRNA expression correlation network was constructed, the potential pathways involving the key lncRNAs were enriched using Gene Set Enrichment Analysis. Among the 61 DE‑lncRNAs, 48 lncRNAs were significantly associated with prognosis. Relapse was an independent prognostic factor. The optimal 14‑lncRNA risk score system was constructed. After 730 differentially expressed mRNAs were identified between the good and bad prognosis groups divided using a prognostic index, the lncRNA‑mRNA expression correlation network was constructed. Enrichment analysis showed that semaphorin‑3C [SEMA3C; regulated by probable leucine‑tRNA ligase, mitochondrial (LARS2‑AS1)] and secreted frizzled‑related protein 5 [SFRP5; mediated by WASH complex subunit 5 (WASHC5)‑antisense RNA 1 (AS1)] were involved in axon guidance and the Wnt signaling pathway, respectively. A 14‑lncRNA (including paired box protein Pax8‑AS1 and MYB AS1) risk‑score system might be effective in predicting the prognosis of AML. Axon guidance (involving SEMA3C and LARS2‑AS1) and the Wnt signaling pathway (involving SFRP5 and WASHC5‑AS1) might be two important pathways affecting the prognosis of AML.
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1 

Clarkson BD: Acute myelocytic leukemia in adults. Cancer. 30:1572–1582. 2015.

2 

Döhner H, Weisdorf DJ and Bloomfield CD: Acute myeloid leukemia. N Engl J Med. 373:1136–1152. 2015.PubMed/NCBI View Article : Google Scholar

3 

Kootte AM, Thompson J and Bruijn JA: Acute myelocytic leukemia with acute aortic occlusion as presenting symptom. Acta Haematol. 75:120–121. 2009.

4 

Pyatt DW, Aylward LL and Hays SM: Is age an independent risk factor for chemically induced acute myelogenous leukemia in children? J Toxicol Environ Health B Crit Rev. 10:379–400. 2007.PubMed/NCBI View Article : Google Scholar

5 

Belson M, Kingsley B and Holmes A: Risk factors for acute leukemia in children: A review. Environ Health Perspect. 115:138–145. 2007.PubMed/NCBI View Article : Google Scholar

6 

Deschler B and Lübbert M: Acute myeloid leukemia: Epidemiology and etiology. Cancer. 107:2099–2107. 2010.

7 

GBD 2015 Mortality and Causes of Death Collaborators: Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet 388: 1459-1544, 2016.

8 

Angrand PO, Vennin C, Le Bourhis X and Adriaenssens E: The role of long non-coding RNAs in genome formatting and expression. Front Genet. 6(165)2015.PubMed/NCBI View Article : Google Scholar

9 

Garzon R, Volinia S, Papaioannou D, Nicolet D, Kohlschmidt J, Yan PS, Mrózek K, Bucci D, Carroll AJ, Baer MR, et al: Expression and prognostic impact of lncRNAs in acute myeloid leukemia. Proc Natl Acad Sci USA. 111:18679–18684. 2014.PubMed/NCBI View Article : Google Scholar

10 

Hao S and Shao Z: HOTAIR is upregulated in acute myeloid leukemia and that indicates a poor prognosis. Int J Clin Exp Pathol. 8:7223–7228. 2015.PubMed/NCBI

11 

Wu S, Zheng C, Chen S, Cai X, Shi Y, Lin B and Chen Y: Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. Oncol Lett. 10:2410–2414. 2015.PubMed/NCBI View Article : Google Scholar

12 

Sun J, Hu J, Li W and Sun Y: A novel suppressive long noncoding RNA within the IGF1R Gene locus is imprinted in acute myelocytic leukemia. Blood. 124(3592)2014.PubMed/NCBI View Article : Google Scholar

13 

Zhao TF, Jia HZ, Zhang ZZ, Zhao XS, Zou YF, Zhang W, Wan J and Chen XF: LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia. Mol Med Rep. 16:3687–3693. 2017.PubMed/NCBI View Article : Google Scholar

14 

Nie Y, Zhou L, Wang H, Chen N, Jia L, Wang C, Wang Y, Chen J, Wen X, Niu C, et al: Profiling the epigenetic interplay of lncRNA RUNXOR and oncogenic RUNX1 in breast cancer cells by gene in situ cis-activation. Am J Cancer Res. 9:1635–1649. 2019.PubMed/NCBI

15 

Wang H, Guo R, Hoffman AR, Hu J and Li W: Effect of long noncoding RNA RUNXOR on the epigenetic regulation of RUNX1 in acute myelocytic leukemia. J Brazilian Soc Mechanical Sci Engineering. 25:341–346. 2015.

16 

Wang F, Tian X, Zhou J, Wang G, Yu W, Li Z, Fan Z, Zhang W and Liang A: A three-lncRNA signature for prognosis prediction of acute myeloid leukemia in patients. Mol Med Rep. 18:1473–1484. 2018.PubMed/NCBI View Article : Google Scholar

17 

Lee SH, Chiu YC, Li YH, Lin CC, Hou HA, Chou WC and Tien HF: High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia. Oncotarget. 8:72250–72259. 2017.PubMed/NCBI View Article : Google Scholar

18 

Anders S and Huber W: Differential expression analysis for sequence count data. Genome Biol. 11(R106)2010.PubMed/NCBI View Article : Google Scholar

19 

Robinson M, Mccarthy D and Smyth GK: edgeR: Differential expression analysis of digital gene expression data. J Hospice Palliative Nurs. 4:206–207. 2010.

20 

Chen LP, Wang H, Zhang Y, Chen QX, Lin TS, Liu ZQ and Zhou YY: Robust analysis of novel mRNA-lncRNA cross talk based on ceRNA hypothesis uncovers carcinogenic mechanism and promotes diagnostic accuracy in esophageal cancer. Cancer Manag Res. 11:347–358. 2018.PubMed/NCBI View Article : Google Scholar

21 

Perron AM, Girolimetti G, Procaccini M, Marchio L, Livi A, Borghese G, Porcelli AM, De Iaco P and Gasparre G: Potential for mitochondrial DNA sequencing in the differential diagnosis of gynaecological malignancies. Int J Mol Sci. 19(pii: E2048)2018.PubMed/NCBI View Article : Google Scholar

22 

He JH, Han ZP, Zou MX, Wang L, Lv YB, Zhou JB, Cao MR and Li YG: Analyzing the LncRNA, miRNA, and mRNA regulatory Network in prostate cancer with Bioinformatics Software. J Comput Biol. 25:146–157. 2018.PubMed/NCBI View Article : Google Scholar

23 

Wang L, Cao C, Ma Q, Zeng Q, Wang H, Cheng Z, Zhu G, Qi J, Ma H, Nian H and Wang Y: RNA-seq analyses of multiple meristems of soybean: Novel and alternative transcripts, evolutionary and functional implications. BMC Plant Biol. 14(169)2014.PubMed/NCBI View Article : Google Scholar

24 

Wang P, Wang Y, Hang B, Zou X and Mao JH: A novel gene expression-based prognostic scoring system to predict survival in gastric cancer. Oncotarget. 7:55343–55351. 2016.PubMed/NCBI View Article : Google Scholar

25 

Goeman JJ: L1 penalized estimation in the Cox proportional hazards model. Biom J. 52:70–84. 2010.PubMed/NCBI View Article : Google Scholar

26 

Ranstam J and Cook JA: Kaplan-meier curve. Br J Surg. 104(442)2017.PubMed/NCBI View Article : Google Scholar

27 

Kaushal B, Jain K and Sharma SK: Estimation of area under receiver operating characteristic curve for Bi-Pareto and Bi-Two parameter exponential models. Open J Statistics. 4:1–10. 2014.

28 

Hauke J and Kossowski T: Comparison of values of Pearson's and Spearman's correlation coefficients on the same sets of data. Quaestiones Geographicae. 30:87–93. 2011.

29 

Tilford CA and Siemers NO: Gene set enrichment analysis. Methods Mol Biol. 563:99–121. 2009.PubMed/NCBI View Article : Google Scholar

30 

Servant N, Roméjon J, Gestraud P, La Rosa P, Lucotte G, Lair S, Bernard V, Zeitouni B, Coffin F, Jules-Clément G, et al: Bioinformatics for precision medicine in oncology: Principles and application to the SHIVA clinical trial. Front Genet. 5(152)2014.PubMed/NCBI View Article : Google Scholar

31 

Zhao X, Li Y and Wu H: A novel scoring system for acute myeloid leukemia risk assessment based on the expression levels of six genes. Int J Mol Med. 42:1495–1507. 2018.PubMed/NCBI View Article : Google Scholar

32 

Li S, Bian H, Cao Y, Juan C, Cao Q, Zhou G and Fang Y: Identification of novel lncRNAs involved in the pathogenesis of childhood acute lymphoblastic leukemia. Oncol Lett. 17:2081–2090. 2019.PubMed/NCBI View Article : Google Scholar

33 

Yin X, Huang S, Zhu R, Fan F, Sun C and Hu Y: Identification of long non-coding RNA competing interactions and biological pathways associated with prognosis in pediatric and adolescent cytogenetically normal acute myeloid leukemia. Cancer Cell Int. 18(122)2018.PubMed/NCBI View Article : Google Scholar

34 

Rossi G, Minervini MM, Carella AM, Melillo L and Cascavilla N: Wilms' tumor gene (WT1) expression and minimal residual disease in acute myeloid leukemia. In: van den Heuvel-Eibrink MM (ed), Wilms Tumor, Brisbane (AU), Codon Publications, 2016.

35 

Siehl JM, Thiel E, Heufelder K, Snarski E, Schwartz S, Mailänder V and Keilholz U: Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias. Br J Haematol. 123:235–242. 2003.PubMed/NCBI View Article : Google Scholar

36 

Han J, Zhou W, Jia M, Wen J, Jiang J, Shi J, Zhang K, Ma H, Liu J, Ren J, et al: Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with decreased risk of cervical cancer. Mol Genet Genomics. 291:1743–1748. 2016.PubMed/NCBI View Article : Google Scholar

37 

Bahari G, Hashemi M, Naderi M, Sadeghi-Bojd S and Taheri M: Long non-coding RNA PAX8-AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia. Biomed Rep. 8:184–190. 2018.PubMed/NCBI View Article : Google Scholar

38 

Ramaswamy K, Forbes L, Minuesa G, Gindin T, Brown F, Kharas MG, Krivtsov AV, Armstrong SA, Still E, de Stanchina E, et al: Peptidomimetic blockade of MYB in acute myeloid leukemia. Nat Commun. 9(110)2018.PubMed/NCBI View Article : Google Scholar

39 

Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F, Mentens N, Beverloo HB, Pieters R, Speleman F, et al: Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat Genet. 39:593–595. 2007.PubMed/NCBI View Article : Google Scholar

40 

Mets E, Van der Meulen J, Van Peer G, Boice M, Mestdagh P, Van de Walle I, Lammens T, Goossens S, De Moerloose B, Benoit Y, et al: MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. Leukemia. 29:798–806. 2015.PubMed/NCBI View Article : Google Scholar

41 

Shuang Y, Ning Q, Zhang G, Hong S, Zhen W and Li Y: Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma. Oncotarget. 7:85728–85740. 2016.PubMed/NCBI View Article : Google Scholar

42 

Li K, Gao B, Li J, Chen H, Li Y, Wei Y, Gong D, Gao J, Zhang J, Tan W, et al: ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription. Oncotarget. 6:38107–38126. 2015.PubMed/NCBI View Article : Google Scholar

43 

Kai L, Bo G, Jun L, Chen H, Li Y, Wei Y, Gong D, Gao J, Zhang J, Tan W, et al: ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription. Oncotarget. 6:38107–38126. 2015.PubMed/NCBI View Article : Google Scholar

44 

Zhang L, Wang JH, Liang RX, Huang ST, Xu J, Yuan LJ, Huang L, Zhou Y, Yu XJ, Wu SY, et al: RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma. Oncotarget. 6:34510–34524. 2015.PubMed/NCBI View Article : Google Scholar

45 

Yeung TL, Leung CS, Wong KK, Gutierrez-Hartmann A, Kwong J, Gershenson DM and Mok SC: ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells. Oncotarget. 8:16951–16963. 2017.PubMed/NCBI View Article : Google Scholar

46 

Harburg GC and Hinck L: Navigating breast cancer: Axon guidance molecules as breast cancer tumor suppressors and oncogenes. J Mammary Gland Biol Neoplasia. 16:257–270. 2011.PubMed/NCBI View Article : Google Scholar

47 

Kerjan G and Moreaufauvarque C: The brain within the tumor: New roles for axon guidance molecules in cancers. Cell Death Differ. 12:1044–1056. 2005.PubMed/NCBI View Article : Google Scholar

48 

Neufeld G, Mumblat Y, Smolkin T, Toledano S, Nir-Zvi I, Ziv K and Kessler O: The role of the semaphorins in cancer. Cell Adh Migr. 10:652–674. 2016.PubMed/NCBI View Article : Google Scholar

49 

Rolny C, Capparuccia L, Casazza A, Mazzone M, Vallario A, Cignetti A, Medico E, Carmeliet P, Comoglio PM and Tamagnone L: The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment. J Exp Med. 205:1155–1171. 2008.PubMed/NCBI View Article : Google Scholar

50 

Minke KS, Staib P, Puetter A, Gehrke I, Gandhirajan RK, Schlösser A, Schmitt EK, Hallek M and Kreuzer KA: Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. Eur J Haematol. 82:165–175. 2010.PubMed/NCBI View Article : Google Scholar

51 

Mikesch JH, Steffen B, Berdel WE, Serve H and Müller-Tidow C: The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. Leukemia. 21:1638–1647. 2007.PubMed/NCBI View Article : Google Scholar

52 

Pehlivan M, Çalışkan C, Yüce Z and Sercan HO: Secreted Wnt antagonists in leukemia: A road yet to be paved. Leuk Res. 69:24–30. 2018.PubMed/NCBI View Article : Google Scholar

53 

Valencia A, Romángómez J, Cervera J, Such E, Barragán E, Bolufer P, Moscardó F, Sanz GF and Sanz MA: Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia. 23:1658–1666. 2009.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Guo S, Li B, Xu X, Wang W, Wang S, Lv T and Wang H: Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia. Exp Ther Med 20: 1521-1531, 2020.
APA
Guo, S., Li, B., Xu, X., Wang, W., Wang, S., Lv, T., & Wang, H. (2020). Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia. Experimental and Therapeutic Medicine, 20, 1521-1531. https://doi.org/10.3892/etm.2020.8846
MLA
Guo, S., Li, B., Xu, X., Wang, W., Wang, S., Lv, T., Wang, H."Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia". Experimental and Therapeutic Medicine 20.2 (2020): 1521-1531.
Chicago
Guo, S., Li, B., Xu, X., Wang, W., Wang, S., Lv, T., Wang, H."Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1521-1531. https://doi.org/10.3892/etm.2020.8846
Copy and paste a formatted citation
x
Spandidos Publications style
Guo S, Li B, Xu X, Wang W, Wang S, Lv T and Wang H: Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia. Exp Ther Med 20: 1521-1531, 2020.
APA
Guo, S., Li, B., Xu, X., Wang, W., Wang, S., Lv, T., & Wang, H. (2020). Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia. Experimental and Therapeutic Medicine, 20, 1521-1531. https://doi.org/10.3892/etm.2020.8846
MLA
Guo, S., Li, B., Xu, X., Wang, W., Wang, S., Lv, T., Wang, H."Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia". Experimental and Therapeutic Medicine 20.2 (2020): 1521-1531.
Chicago
Guo, S., Li, B., Xu, X., Wang, W., Wang, S., Lv, T., Wang, H."Construction of a 14‑lncRNA risk score system predicting survival of children with acute myelocytic leukemia". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1521-1531. https://doi.org/10.3892/etm.2020.8846
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