Open Access

Gene expression profile analysis on different stages of hypertrophic scarring in a rabbit ear model

  • Authors:
    • Ji Zhu
    • Mengyan Sun
    • Yuchong Wang
    • Hongda Bi
    • Chunyu Xue
  • View Affiliations

  • Published online on: June 11, 2020     https://doi.org/10.3892/etm.2020.8879
  • Pages: 1505-1513
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypertrophic scarring (HS) is one of the most common skin disorders. The study aimed to investigate the gene expression profile at day 10 (Stage 1), 21 (Stage 2), and day 40 (Stage 3) post‑wounding of HS using RNA‑sequencing of a scar model from rabbit ears. A total of 17,386 unigenes were annotated using the eggNOG Functional Category database. The study identified significantly differentially expressed genes (DEGs) including 261, 141, and 247 upregulated ones as well as 253, 272, and 58 downregulated ones in three stages respectively. The DEGs varies among each stage measured by Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. DEGs were enriched in ‘immune system process’ and ‘proteinaceous extracellular matrix’ in Stage 1, ‘anatomical structure development’, ‘cell differentiation’, ‘cell adhesion’and some other terms in Stage 2, ‘cancers’, ‘proteinaceous extracellular matrix’ and ‘signal transduction’ in Stage 3. Furthermore, the Wnt signaling pathway was found to play a pivotal role in regression of HS. In conclusion, we revealed comprehensively the gene expression profiles during HS formation providing probable targets in HS treatment.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhu J, Sun M, Wang Y, Bi H and Xue C: Gene expression profile analysis on different stages of hypertrophic scarring in a rabbit ear model. Exp Ther Med 20: 1505-1513, 2020
APA
Zhu, J., Sun, M., Wang, Y., Bi, H., & Xue, C. (2020). Gene expression profile analysis on different stages of hypertrophic scarring in a rabbit ear model. Experimental and Therapeutic Medicine, 20, 1505-1513. https://doi.org/10.3892/etm.2020.8879
MLA
Zhu, J., Sun, M., Wang, Y., Bi, H., Xue, C."Gene expression profile analysis on different stages of hypertrophic scarring in a rabbit ear model". Experimental and Therapeutic Medicine 20.2 (2020): 1505-1513.
Chicago
Zhu, J., Sun, M., Wang, Y., Bi, H., Xue, C."Gene expression profile analysis on different stages of hypertrophic scarring in a rabbit ear model". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1505-1513. https://doi.org/10.3892/etm.2020.8879