Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure

  • Authors:
    • Jin‑Bo Zhang
    • Jin‑Qiang Zhu
    • Lie‑Xiang Cao
    • Xiao‑Hong Jin
    • Li‑Li Chen
    • Yu‑Kang Song
    • Shi‑Fang Zhou
    • Ji‑Hong Ma
    • Hui Fu
    • Jin‑Zhong Xu
    • Mei‑Ping Dong
    • Lai‑Chao Yan
    • Xian‑Dan Wu
    • Hui‑Ping Wang
    • Jun‑Yang Zhou
    • Yan‑Qiu Wang
  • View Affiliations / Copyright

    Affiliations: Emergency Intensive Care Unit, Wenling Hospital Affiliated to Wenzhou Medical University, The First People's Hospital of Wenling, Wenling, Zhejiang 317500, P.R. China, Department of Emergency Care, Changsha Central Hospital, Changsha, Hunan 410004, P.R. China, Intensive Care Unit, First Affiliated Hospital of Wenzhou Medical University, Wenling, Zhejiang 325000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1441-1446
    |
    Published online on: June 12, 2020
       https://doi.org/10.3892/etm.2020.8884
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sequential invasive-noninvasive ventilation (NIV) improves the outcomes of patients with respiratory failure caused by acute exacerbation of chronic obstructive pulmonary disease (AECOPD); however, there is no clear consensus on the optimal timing of the switch to sequential invasive‑NIV in these patients. In the present study, a potential role for the modified Glasgow Coma Scale (GCS) score to guide sequential weaning was investigated. Patients with AECOPD and respiratory failure were prospectively recruited from three study centers (Wenling Hospital Affiliated to Wenzhou Medical University, the First Affiliated Hospital of Wenzhou Medical University and Changsha Central Hospital) between January 1st 2016 and December 31st 2018. Patients were randomly assigned to group A and B, with the switching point for sequential weaning strategy in the two groups being a modified GCS score ≥13 and 10 points, respectively. Each group included 240 patients. Baseline demographic characteristics were comparable in the two groups. The duration of invasive mechanical ventilation (IMV) in group A was significantly shorter than that in group B. However, there were no significant between‑group differences with respect to the incidence of re‑intubation, ventilator‑associated pneumonia, in‑hospital mortality or the length of hospital stay. Use of a modified GCS score ≥13 as the switching point for sequential invasive‑NIV may help decrease the duration of IMV in patients with AECOPD and respiratory failure.
View Figures

Figure 1

View References

1 

Adeloye D, Chua S, Lee C, Basquill C, Papana A, Theodoratou E, Nair H, Gasevic D, Sridhar D, Campbell H, et al: Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J Glob Health. 5(020415)2015.PubMed/NCBI View Article : Google Scholar

2 

Rothberg MB, Pekow PS, Maureen L, Oren B, Skiest DJ and Lindenauer PK: Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease. JAMA. 303:2035–2042. 2010.PubMed/NCBI View Article : Google Scholar

3 

Afessa B, Morales I, Scanlon PD and Peters SG: Prognostic factors, clinical course, and hospital outcome of patients with chronic obstructive pulmonary disease admitted to an intensive care unit for acute respiratory failure. Crit Care Med. 30:1610–1615. 2002.PubMed/NCBI View Article : Google Scholar

4 

Plant PK, Owen JL and Elliott MW: Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: A multicentre randomised controlled trial. Lancet. 355:1931–1935. 2000.PubMed/NCBI View Article : Google Scholar

5 

Stefan MS, Shieh MS, Pekow PS, Hill N, Rothberg MB and Lindenauer PK: Trends in mechanical ventilation among patients hospitalized with acute exacerbations of COPD in the United States, 2001 to 2011. Chest. 147:959–968. 2015.PubMed/NCBI View Article : Google Scholar

6 

Ai-Ping C, Lee KH and Lim TK: In-hospital and 5-year mortality of patients treated in the ICU for acute exacerbation of COPD: A retrospective study. Chest. 128:518–524. 2005.PubMed/NCBI View Article : Google Scholar

7 

Michelle B, Kashiouris MG and Ognjen G: Ventilator-induced lung injury: Minimizing its impact in patients with or at risk for ARDS. Respir Care. 58:927–934. 2013.PubMed/NCBI View Article : Google Scholar

8 

Forel JM, Voillet F, Pulina D, Gacouin A, Perrin G, Barrau K, Jaber S, Arnal JM, Fathallah M and Auquier P: Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy. Crit Care. 16(R65)2012.PubMed/NCBI View Article : Google Scholar

9 

Lv Y, Lv Q, Lv Q and Lai T: Pulmonary infection control window as a switching point for sequential ventilation in the treatment of COPD patients: A meta-analysis. Int J Chron Obstruct Pulmon Dis. 12:1255–1267. 2017.PubMed/NCBI View Article : Google Scholar

10 

Frutos-Vivar F, Esteban A, Apezteguia C, González M, Arabi Y, Restrepo MI, Gordo F, Santos C, Alhashemi JA, Pérez FJ, et al: Outcome of reintubated patients after scheduled extubation. J Crit Care. 26:502–509. 2011.PubMed/NCBI View Article : Google Scholar

11 

Huang CT and Yu CJ: Conventional weaning parameters do not predict extubation outcome in intubated subjects requiring prolonged mechanical ventilation. Respir Care. 58:1307–1314. 2013.PubMed/NCBI View Article : Google Scholar

12 

Hendra KP, Bonis PA and Joyce-Brady M: Development and prospective validation of a model for predicting weaning in chronic ventilator dependent patients. BMC Pulm Med. 3(3)2003.PubMed/NCBI View Article : Google Scholar

13 

Wu YK, Kao KC, Hsu KH, Hsieh MJ and Tsai YH: Predictors of successful weaning from prolonged mechanical ventilation in Taiwan. Respir Med. 103:1189–1195. 2009.PubMed/NCBI View Article : Google Scholar

14 

Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Chen R, Decramer M, Fabbri LM, et al: Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD Executive Summary. Am J Respir Crit Care Med. 195:557–582. 2017.PubMed/NCBI View Article : Google Scholar

15 

Ornico SR, Lobo SM, Sanches HS, Deberaldini M, Tófoli LT, Vidal AM, Schettino GP, Amato MB, Carvalho CR and Barbas CS: Noninvasive ventilation immediately after extubation improves weaning outcome after acute respiratory failure: A randomized controlled trial. Crit Care. 17(R39-R39)2013.PubMed/NCBI View Article : Google Scholar

16 

Vasilevskis EE, Pandharipande PP, Graves AJ, Shintani A, Tsuruta R, Ely EW and Girard TD: Validity of a modified sequential organ failure assessment score using the richmond agitation-sedation scale. Crit Care Med. 44:138–146. 2016.PubMed/NCBI View Article : Google Scholar

17 

Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A and Welte T: Weaning from mechanical ventilation. Eur Respir J. 29:1033–1056. 2007.PubMed/NCBI View Article : Google Scholar

18 

Burns KEA, Karim HMR and Esquinas AM: Characteristic of Subjects Who Fail a 120-minute spontaneous breathing trial: When minutes are taken into account. Respir Care. 64(114)2019.PubMed/NCBI View Article : Google Scholar

19 

Kallet RH: Ventilator bundles in transition: From prevention of ventilator-associated pneumonia to prevention of ventilator-associated events. Respir Care. 64:994–1006. 2019.PubMed/NCBI View Article : Google Scholar

20 

Luo Z, Zhan Q and Wang C: Noninvasive positive pressure ventilation is required following extubation at the pulmonary infection control window: A prospective observational study. Clin Respir J. 8:338–349. 2014.PubMed/NCBI View Article : Google Scholar

21 

Perkins GD, Mistry D, Gates S, Gao F, Snelson C, Hart N, Camporota L, Varley J, Carle C, Paramasivam E, et al: Effect of protocolized weaning with early extubation to noninvasive ventilation vs invasive weaning on time to liberation from mechanical ventilation among patients with respiratory failure: The breathe randomized clinical trial. JAMA. 320:1881–1888. 2018.PubMed/NCBI View Article : Google Scholar

22 

Briones Claudett KH, Briones Claudett M, Chung Sang Wong M, Nuques Martinez A, Soto Espinoza R, Montalvo M, Esquinas Rodriguez A, Gonzalez Diaz G and Grunauer Andrade M: Noninvasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease and hypercapnic encephalopathy. BMC Pulm Med. 13(12)2013. View Article : Google Scholar

23 

Ciftci F, Ciledag A, Erol S, Oz M, Acar D and Kaya A: Evaluation of the feasibility of average volume-assured pressure support ventilation in the treatment of acute hypercapnic respiratory failure associated with chronic obstructive pulmonary disease: A pilot study. J Crit Care. 39:232–237. 2017.PubMed/NCBI View Article : Google Scholar

24 

Moskopp D, Stahle C and Wassmann H: Problems of the Glasgow Coma Scale with early intubated patients. Neurosurg Rev. 18:253–257. 1995.PubMed/NCBI View Article : Google Scholar

25 

Zhang J, Zhu J, Zhou S, Ma J, Fu H, Song Y, Xu J, Cao L, Dong M, Yan L, et al: Noninvasive mechanical ventilation in the weaning of AECOPD patients with respiratory failure: Modified glasgow coma scale score ≥13 as the switching point. Int J Clinical Exp Med. 12:7808–7813. 2019.

26 

Chen XLaW: Clincial investigation of modified GCS ≥10 points as the switching point of sequantial sequential invasive-noninvasive mechanical ventilation weaning in AECOPD patients with respiratory failure. Chong Qing Yi Xue. 45:1381–1383. 2016.(In Chinese).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang JB, Zhu JQ, Cao LX, Jin XH, Chen LL, Song YK, Zhou SF, Ma JH, Fu H, Xu JZ, Xu JZ, et al: Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure. Exp Ther Med 20: 1441-1446, 2020.
APA
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y. ... Wang, Y. (2020). Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure. Experimental and Therapeutic Medicine, 20, 1441-1446. https://doi.org/10.3892/etm.2020.8884
MLA
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y., Zhou, S., Ma, J., Fu, H., Xu, J., Dong, M., Yan, L., Wu, X., Wang, H., Zhou, J., Wang, Y."Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure". Experimental and Therapeutic Medicine 20.2 (2020): 1441-1446.
Chicago
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y., Zhou, S., Ma, J., Fu, H., Xu, J., Dong, M., Yan, L., Wu, X., Wang, H., Zhou, J., Wang, Y."Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1441-1446. https://doi.org/10.3892/etm.2020.8884
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang JB, Zhu JQ, Cao LX, Jin XH, Chen LL, Song YK, Zhou SF, Ma JH, Fu H, Xu JZ, Xu JZ, et al: Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure. Exp Ther Med 20: 1441-1446, 2020.
APA
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y. ... Wang, Y. (2020). Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure. Experimental and Therapeutic Medicine, 20, 1441-1446. https://doi.org/10.3892/etm.2020.8884
MLA
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y., Zhou, S., Ma, J., Fu, H., Xu, J., Dong, M., Yan, L., Wu, X., Wang, H., Zhou, J., Wang, Y."Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure". Experimental and Therapeutic Medicine 20.2 (2020): 1441-1446.
Chicago
Zhang, J., Zhu, J., Cao, L., Jin, X., Chen, L., Song, Y., Zhou, S., Ma, J., Fu, H., Xu, J., Dong, M., Yan, L., Wu, X., Wang, H., Zhou, J., Wang, Y."Use of the modified Glasgow Coma Scale score to guide sequential invasive‑noninvasive mechanical ventilation weaning in patients with AECOPD and respiratory failure". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1441-1446. https://doi.org/10.3892/etm.2020.8884
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team