Open Access

SMYD3 promotes colon adenocarcinoma (COAD) progression by mediating cell proliferation and apoptosis

  • Authors:
    • Fu‑Ren Yue
    • Zhi‑Bin Wei
    • Rui‑Zhen Yan
    • Qiu‑Hong Guo
    • Bing Liu
    • Jing‑Hui Zhang
    • Zheng Li
  • View Affiliations

  • Published online on: August 25, 2020     https://doi.org/10.3892/etm.2020.9139
  • Article Number: 11
  • Copyright: © Yue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colon adenocarcinoma (COAD) is a type of common malignant tumor originating in the digestive tract. Recently, targeted therapy has had significant effects on the treatment of COAD. However, more effective molecular targets need to be developed. SET and MYND domain‑containing protein 3 (SMYD3) is a type of methyltransferase which methylates histone and non‑histone proteins. The effects of SMYD3 on cancer progression and metastasis have been widely revealed. However, its possible role in COAD remains unclear. The current study demonstrated that SMYD3 expression was upregulated in human COAD tissues via analyzing the The Cancer Genome Atlas (TCGA) database and the immunohistochemical assays. Furthermore, the expression of SMYD3 was correlated with prognosis and tumor stage (P=0.038) in patients with COAD. Colony formation, MTT, FCM assays and animal assays indicated SMYD3 affected the proliferation, apoptosis and the cell cycle of COAD cells in vitro and promoted tumor growth in mice in vivo. In summary, the results demonstrated the effects of SMYD3 on COAD progression and we hypothesized that SMYD3 is a novel molecular target for COAD treatment.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yue FR, Wei ZB, Yan RZ, Guo QH, Liu B, Zhang JH and Li Z: SMYD3 promotes colon adenocarcinoma (COAD) progression by mediating cell proliferation and apoptosis. Exp Ther Med 20: 11, 2020
APA
Yue, F., Wei, Z., Yan, R., Guo, Q., Liu, B., Zhang, J., & Li, Z. (2020). SMYD3 promotes colon adenocarcinoma (COAD) progression by mediating cell proliferation and apoptosis. Experimental and Therapeutic Medicine, 20, 11. https://doi.org/10.3892/etm.2020.9139
MLA
Yue, F., Wei, Z., Yan, R., Guo, Q., Liu, B., Zhang, J., Li, Z."SMYD3 promotes colon adenocarcinoma (COAD) progression by mediating cell proliferation and apoptosis". Experimental and Therapeutic Medicine 20.5 (2020): 11.
Chicago
Yue, F., Wei, Z., Yan, R., Guo, Q., Liu, B., Zhang, J., Li, Z."SMYD3 promotes colon adenocarcinoma (COAD) progression by mediating cell proliferation and apoptosis". Experimental and Therapeutic Medicine 20, no. 5 (2020): 11. https://doi.org/10.3892/etm.2020.9139