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Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study

  • Authors:
    • Cheng-Yun Zhang
    • Dong‑Jie Liu
    • Shao-Dong Hua
    • Shan  Guo
    • Xiao-Yan Li
    • Bing Zhang
    • Li-Hua An
  • View Affiliations / Copyright

    Affiliations: Department of Neonatology, The First People's Hospital of Zhengzhou City, Zhengzhou, Henan 450000, P.R. China, Newborn Intensive Care Unit, The Seventh Medical Center of The Chinese People's Liberation Army, Affiliated Bayi Children's Hospital, Beijing 100700, P.R. China, Department of Obstetrics, The First People's Hospital of Zhengzhou City, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 46
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    Published online on: September 3, 2020
       https://doi.org/10.3892/etm.2020.9175
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Abstract

The present study was conducted to investigate the clinical significance of caffeine and aminophylline in the treatment of premature infants with apnea under varying conditions of oxygen (O2) delivery. The clinical data of 120 premature infants with apnea treated with oxygen therapy and either caffeine citrate (20 mg/kg/day; n=77) or aminophylline (10 mg/kg/day; n=43) were retrospectively examined. The therapeutic performance of the drugs after the completion of the treatment was evaluated primarily according to the risk of recurrent episodes of apnea, the changes in the duration and concentration of inhaled O2 and the incidence of complications. In contrast to aminophylline, caffeine treatment significantly reduced the duration of O2 inhalation and the inhaled O2 concentration in the infants treated with mechanical ventilation or O2 delivery devices (P<0.05). Treatment with caffeine also decreased the incidence of recurrent apnea events and complications in the investigated population (P<0.05 or P<0.01). Caffeine performs better than aminophylline in the treatment of premature infants with apnea under different conditions of O2 delivery. The therapeutic performance of caffeine is achieved primarily via improving the efficacy of supplemental O2 and reducing the incidence of complications.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Liu DJ, Hua S, Guo S, Li X, Zhang B and An L: Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study. Exp Ther Med 20: 46, 2020.
APA
Zhang, C., Liu, D., Hua, S., Guo, S., Li, X., Zhang, B., & An, L. (2020). Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study. Experimental and Therapeutic Medicine, 20, 46. https://doi.org/10.3892/etm.2020.9175
MLA
Zhang, C., Liu, D., Hua, S., Guo, S., Li, X., Zhang, B., An, L."Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study". Experimental and Therapeutic Medicine 20.5 (2020): 46.
Chicago
Zhang, C., Liu, D., Hua, S., Guo, S., Li, X., Zhang, B., An, L."Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study". Experimental and Therapeutic Medicine 20, no. 5 (2020): 46. https://doi.org/10.3892/etm.2020.9175
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Liu DJ, Hua S, Guo S, Li X, Zhang B and An L: Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study. Exp Ther Med 20: 46, 2020.
APA
Zhang, C., Liu, D., Hua, S., Guo, S., Li, X., Zhang, B., & An, L. (2020). Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study. Experimental and Therapeutic Medicine, 20, 46. https://doi.org/10.3892/etm.2020.9175
MLA
Zhang, C., Liu, D., Hua, S., Guo, S., Li, X., Zhang, B., An, L."Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study". Experimental and Therapeutic Medicine 20.5 (2020): 46.
Chicago
Zhang, C., Liu, D., Hua, S., Guo, S., Li, X., Zhang, B., An, L."Caffeine versus aminophylline in combination with oxygen therapy for apnea of prematurity: A retrospective cohort study". Experimental and Therapeutic Medicine 20, no. 5 (2020): 46. https://doi.org/10.3892/etm.2020.9175
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