Open Access

Helicobacter pylori is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

  • Authors:
    • Meng He
    • Yuanyuan Zheng
    • A'huo Ma
    • Chunyi Zhang
    • Yuefang Yu
    • Hua Wang
    • Yefeng Chen
    • Min Xiang
    • Kelong Tao
    • Juxin Shen
  • View Affiliations

  • Published online on: September 3, 2020     https://doi.org/10.3892/etm.2020.9176
  • Article Number: 47
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the potential association between Helicobacter pylori (a H. pylori) positive state and chronic cough. A clinical observational study with systematic analysis was performed, including 278 patients with complaints of chronic cough and 148 healthy controls. a H. pylori positive state was present in 61.2% of the patients in the chronic cough group and 68.9% in the chronic refractory cough group, as opposed to 43.9% in the control group. There was a significant improvement in 65.5% of the patients with chronic refractory cough following successful a H. pylori eradication therapy. In addition, patients with chronic cough exposed to a H. pylori exhibited decreased pulmonary function with a decrease in forced expiratory volume in 1 sec by 84 ml, a decrease in the forced vital capacity by 53 ml and a decrease in maximal vital capacity by 46 ml. The difference was even more obvious in the chronic refractory cough group. The allergy status differed significantly according to age between a H. pylori‑positive and ‑negative cases in the cough variant asthma and allergic cough groups. Among patients aged <40 years, a H. pylori‑positive cases had a lower prevalence of atopy and lower total serum immunoglobin E levels compared with a H. pylori‑negative cases. However, there was no significant association between a H. pylori status and C‑reactive protein levels, erythrocyte sedimentation rate or eosinophil count in the peripheral blood. In conclusion, the present study demonstrated that a H. pylori infection may be a factor associated with chronic cough and it may be associated with a decline in pulmonary function and reduced incidence of allergic conditions. Thus, a H. pylori may represent a target for the treatment of chronic cough.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
He M, Zheng Y, Ma A, Zhang C, Yu Y, Wang H, Chen Y, Xiang M, Tao K, Shen J, Shen J, et al: <em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. Exp Ther Med 20: 47, 2020
APA
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H. ... Shen, J. (2020). <em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. Experimental and Therapeutic Medicine, 20, 47. https://doi.org/10.3892/etm.2020.9176
MLA
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H., Chen, Y., Xiang, M., Tao, K., Shen, J."<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough". Experimental and Therapeutic Medicine 20.5 (2020): 47.
Chicago
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H., Chen, Y., Xiang, M., Tao, K., Shen, J."<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough". Experimental and Therapeutic Medicine 20, no. 5 (2020): 47. https://doi.org/10.3892/etm.2020.9176