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Helicobacter pylori is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

  • Authors:
    • Meng He
    • Yuanyuan Zheng
    • A'huo Ma
    • Chunyi Zhang
    • Yuefang Yu
    • Hua Wang
    • Yefeng Chen
    • Min Xiang
    • Kelong Tao
    • Juxin Shen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China, Department of Gastroenterology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China, Department of Gastrointestinal Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 47
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    Published online on: September 3, 2020
       https://doi.org/10.3892/etm.2020.9176
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Abstract

The present study aimed to investigate the potential association between Helicobacter pylori (a H. pylori) positive state and chronic cough. A clinical observational study with systematic analysis was performed, including 278 patients with complaints of chronic cough and 148 healthy controls. a H. pylori positive state was present in 61.2% of the patients in the chronic cough group and 68.9% in the chronic refractory cough group, as opposed to 43.9% in the control group. There was a significant improvement in 65.5% of the patients with chronic refractory cough following successful a H. pylori eradication therapy. In addition, patients with chronic cough exposed to a H. pylori exhibited decreased pulmonary function with a decrease in forced expiratory volume in 1 sec by 84 ml, a decrease in the forced vital capacity by 53 ml and a decrease in maximal vital capacity by 46 ml. The difference was even more obvious in the chronic refractory cough group. The allergy status differed significantly according to age between a H. pylori‑positive and ‑negative cases in the cough variant asthma and allergic cough groups. Among patients aged <40 years, a H. pylori‑positive cases had a lower prevalence of atopy and lower total serum immunoglobin E levels compared with a H. pylori‑negative cases. However, there was no significant association between a H. pylori status and C‑reactive protein levels, erythrocyte sedimentation rate or eosinophil count in the peripheral blood. In conclusion, the present study demonstrated that a H. pylori infection may be a factor associated with chronic cough and it may be associated with a decline in pulmonary function and reduced incidence of allergic conditions. Thus, a H. pylori may represent a target for the treatment of chronic cough.
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Copy and paste a formatted citation
Spandidos Publications style
He M, Zheng Y, Ma A, Zhang C, Yu Y, Wang H, Chen Y, Xiang M, Tao K, Shen J, Shen J, et al: <em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. Exp Ther Med 20: 47, 2020.
APA
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H. ... Shen, J. (2020). <em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. Experimental and Therapeutic Medicine, 20, 47. https://doi.org/10.3892/etm.2020.9176
MLA
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H., Chen, Y., Xiang, M., Tao, K., Shen, J."<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough". Experimental and Therapeutic Medicine 20.5 (2020): 47.
Chicago
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H., Chen, Y., Xiang, M., Tao, K., Shen, J."<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough". Experimental and Therapeutic Medicine 20, no. 5 (2020): 47. https://doi.org/10.3892/etm.2020.9176
Copy and paste a formatted citation
x
Spandidos Publications style
He M, Zheng Y, Ma A, Zhang C, Yu Y, Wang H, Chen Y, Xiang M, Tao K, Shen J, Shen J, et al: <em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. Exp Ther Med 20: 47, 2020.
APA
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H. ... Shen, J. (2020). <em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough. Experimental and Therapeutic Medicine, 20, 47. https://doi.org/10.3892/etm.2020.9176
MLA
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H., Chen, Y., Xiang, M., Tao, K., Shen, J."<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough". Experimental and Therapeutic Medicine 20.5 (2020): 47.
Chicago
He, M., Zheng, Y., Ma, A., Zhang, C., Yu, Y., Wang, H., Chen, Y., Xiang, M., Tao, K., Shen, J."<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough". Experimental and Therapeutic Medicine 20, no. 5 (2020): 47. https://doi.org/10.3892/etm.2020.9176
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