Associations between the concentrations of CD68, TGF‑&beta;1, renal injury index and prognosis in glomerular diseases

Sun,Jingshu; Hao,Lihai; Shi,Hongbo

doi:10.3892/etm.2020.9184

Associations between the concentrations of CD68, TGF‑β1, renal injury index and prognosis in glomerular diseases

Authors:
- Jingshu Sun
- Lihai Hao
- Hongbo Shi
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Affiliations: Department of Nephrology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
Published online on: September 4, 2020 https://doi.org/10.3892/etm.2020.9184
Article Number: 56
Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the association between the concentrations of CD68, TGF‑β1, renal injury index and prognosis in glomerular diseases. Altogether 218 patients with glomerular diseases admitted to Weifang People's Hospital from January, 2014 to March, 2017 were used as the study group. A total of 100 healthy individuals who visited Weifang People's Hospital for a physical examination during the same time period were used as the control group. The levels of CD68 in peripheral blood obtained from the 2 groups of subjects were detected by flow cytometry, and the expression of TGF‑β1 in serum was detected by enzyme‑linked immunosorbent assay (ELISA). The concentrations of CD68 and TGF‑β1 between the 2 groups were compared. The correlation between the concentrations of CD68, TGF‑β1 and renal injury indexes in the study group was analyzed, as well as prognostic significance. The diagnostic value of CD68 and TGF‑β1 in patients with glomerular disease was analyzed using a ROC curve, and the recovery of the patients was observed. The serum concentrations of CD68 and TGF‑β1 in the study group were higher than those in the control group (P<0.05). The concentrations of CD68 and TGF‑β1 in the study group positively correlated with the renal injury indexes, such as blood urea nitrogen (BUN), serum creatinine (SCR), uric acid (UA) and the 24‑h urinary protein quantity (P<0.05). ROC curve analysis revealed that the area under the curve of CD68 and TGF‑β1 as regards the diagnostic value in patients with glomerular disease was 0.808 and 0.738, respectively, while the area under the combined detection curve was 0.866. Multivariate unconditional logistic regression analysis revealed that the clinical classification and the concentrations of CD68 and TGF‑β1 were independent prognostic factors in the study group. On the whole, the findings of the present study demonstrate that clinical classification, and the CD68 and TGF‑β1 concentrations are independent prognostic factors for patients with glomerular disease. CD68 and TGF‑β1 have certain value in the diagnosis of glomerular diseases, and may thus be used as predictors of the diagnosis and recovery of glomerular disease.

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