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Article

Beneficial effect of black rice (Oryza sativa L. var. japonica) extract on amyloid β‑induced cognitive dysfunction in a mouse model

  • Authors:
    • Ah Young Lee
    • Ji Myung Choi
    • Young A. Lee
    • Seon Hwa Shin
    • Eun Ju Cho
  • View Affiliations / Copyright

    Affiliations: Department of Food Science, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea, Department of Food Science and Nutrition, Research Institute of Ecology, Pusan National University, Busan 46241, Republic of Korea, Department of Food Science and Nutrition, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea
  • Article Number: 64
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    Published online on: September 9, 2020
       https://doi.org/10.3892/etm.2020.9192
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Abstract

Alzheimer's disease (AD) is an age‑dependent progressive neurodegenerative disease, resulting in memory loss and cognitive dysfunction. The accumulation of amyloid β (Aβ) has been identified as the most important risk factor for AD. Black rice (BR; Oryza sativa L. var. japonica), which is widely consumed in Asia, is a good source of bioactive compounds including anthocyanins. Therefore, the aim of the present study was to evaluate the protective effect of BR extracts against Aβ25‑35‑induced memory impairment in an in vivo AD mouse model. After intracerebroventricular injection of Aβ25‑35, mice were treated with BR extract supplementation for 14 days. Memory and cognition function were evaluated over this period in both treated and untreated animals using T‑maze, novel object recognition and Morris water maze tests. After behavioral tests, malondialdehyde (MDA) and nitric oxide (NO) concentrations in brain, liver and kidney tissues were analyzed. Mice treated with Aβ25‑35 had impaired memory and cognitive function; however, mice administered BR extract (100 mg/kg/day) demonstrated an improvement in cognition and memory function compared with the Aβ25‑35‑injected control group. Furthermore, injection of Aβ25‑35 significantly increased MDA and NO generation in the brain, liver and kidney of mice. However, the group administered with BR extract had significantly inhibited lipid peroxidation and NO generation in the brain, liver and kidney. In addition, the protective effect of BR on lipid peroxidation and NO production by Aβ25‑35 was stronger in the brain compared with other tissues. Collectively, these findings suggested that BR supplementation may prevent memory and cognition deficits caused by Aβ25‑35‑induced oxidative stress.
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Spandidos Publications style
Lee A, Choi J, Lee Y, Shin S and Cho E: Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model. Exp Ther Med 20: 64, 2020.
APA
Lee, A., Choi, J., Lee, Y., Shin, S., & Cho, E. (2020). Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model. Experimental and Therapeutic Medicine, 20, 64. https://doi.org/10.3892/etm.2020.9192
MLA
Lee, A., Choi, J., Lee, Y., Shin, S., Cho, E."Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model". Experimental and Therapeutic Medicine 20.5 (2020): 64.
Chicago
Lee, A., Choi, J., Lee, Y., Shin, S., Cho, E."Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model". Experimental and Therapeutic Medicine 20, no. 5 (2020): 64. https://doi.org/10.3892/etm.2020.9192
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Spandidos Publications style
Lee A, Choi J, Lee Y, Shin S and Cho E: Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model. Exp Ther Med 20: 64, 2020.
APA
Lee, A., Choi, J., Lee, Y., Shin, S., & Cho, E. (2020). Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model. Experimental and Therapeutic Medicine, 20, 64. https://doi.org/10.3892/etm.2020.9192
MLA
Lee, A., Choi, J., Lee, Y., Shin, S., Cho, E."Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model". Experimental and Therapeutic Medicine 20.5 (2020): 64.
Chicago
Lee, A., Choi, J., Lee, Y., Shin, S., Cho, E."Beneficial effect of black rice (<em>Oryza</em>&nbsp;<em>sativa</em>&nbsp;<em>L</em>. var.&nbsp;<em>japonica</em>) extract on amyloid &beta;‑induced cognitive dysfunction in a mouse model". Experimental and Therapeutic Medicine 20, no. 5 (2020): 64. https://doi.org/10.3892/etm.2020.9192
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