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Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study

  • Authors:
    • Jianfeng Tu
    • Jingzhu Zhang
    • Yue Yang
    • Qiuran Xu
    • Lu  Ke
    • Zhihui Tong
    • Weiqin Li
    • Jieshou Li
  • View Affiliations / Copyright

    Affiliations: Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China, Institute of Innovation and Entrepreneurship, Hangzhou Medical College, Hangzhou, Zhejiang 310053, P.R. China, Department of Emergency Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China
    Copyright: © Tu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 75
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    Published online on: September 10, 2020
       https://doi.org/10.3892/etm.2020.9203
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Abstract

The present study aimed to determine whether a difference in pancreatic function and quality of life (QoL) is present between patients with infected pancreatitis necrosis (IPN) undergoing open necrosectomy (ON) and minimally invasive drainage (MID). The medical records of patients with IPN discharged from Jinling Hospital were retrospectively analyzed. Pancreatic function and QoL were compared between patients treated with ON and MID. Pancreatic endocrine and exocrine function were assessed using the oral glucose tolerance test and fecal elastase‑1 (FE‑1) test, respectively. The standard Short Form 36 health questionnaire was used to evaluate the QoL of patients. The analysis included 101 patients who underwent either ON (n=40, 39.6%) or MID (n=61, 60.4%). There were no significant differences in exocrine and endocrine pancreatic function between the two groups evaluated based on FE‑1, fasting blood glucose, glycated hemoglobin and 2‑h plasma glucose (P<0.05). The scores of the QoL questionnaire were significantly higher in patients treated with MID than in patients treated with ON, including the scores of general health perception (19.39±3.07 vs. 17.37±3.63, P=0.003), vitality (18.93±2.88 vs. 17.57±3.47, P=0.035), social role functioning (8.85±1.43 vs. 8.15±1.98, P=0.042), emotional role functioning (5.33±1.07 vs. 4.82±1.25, P=0.034), mental health (24.21±3.31 vs. 22.57±3.91, P=0.026) and the total QoL score (125.12±13.16 vs. 116.50±16.94, P=0.005). In conclusion, although the initial health of the patient may have influenced the treatment provided, patients with IPN who received MID achieved a better post‑treatment QoL than those treated with ON. No significant differences between the two groups were observed regarding the endocrine and exocrine functions of the pancreas.
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Copy and paste a formatted citation
Spandidos Publications style
Tu J, Zhang J, Yang Y, Xu Q, Ke L, Tong Z, Li W and Li J: Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study. Exp Ther Med 20: 75, 2020.
APA
Tu, J., Zhang, J., Yang, Y., Xu, Q., Ke, L., Tong, Z. ... Li, J. (2020). Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study. Experimental and Therapeutic Medicine, 20, 75. https://doi.org/10.3892/etm.2020.9203
MLA
Tu, J., Zhang, J., Yang, Y., Xu, Q., Ke, L., Tong, Z., Li, W., Li, J."Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study". Experimental and Therapeutic Medicine 20.5 (2020): 75.
Chicago
Tu, J., Zhang, J., Yang, Y., Xu, Q., Ke, L., Tong, Z., Li, W., Li, J."Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study". Experimental and Therapeutic Medicine 20, no. 5 (2020): 75. https://doi.org/10.3892/etm.2020.9203
Copy and paste a formatted citation
x
Spandidos Publications style
Tu J, Zhang J, Yang Y, Xu Q, Ke L, Tong Z, Li W and Li J: Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study. Exp Ther Med 20: 75, 2020.
APA
Tu, J., Zhang, J., Yang, Y., Xu, Q., Ke, L., Tong, Z. ... Li, J. (2020). Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study. Experimental and Therapeutic Medicine, 20, 75. https://doi.org/10.3892/etm.2020.9203
MLA
Tu, J., Zhang, J., Yang, Y., Xu, Q., Ke, L., Tong, Z., Li, W., Li, J."Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study". Experimental and Therapeutic Medicine 20.5 (2020): 75.
Chicago
Tu, J., Zhang, J., Yang, Y., Xu, Q., Ke, L., Tong, Z., Li, W., Li, J."Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study". Experimental and Therapeutic Medicine 20, no. 5 (2020): 75. https://doi.org/10.3892/etm.2020.9203
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