Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin
- Xu Bai
- Qun Luo
- Kuibi Tan
- Liming Guo
Affiliations: Department of Nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315000, P.R. China
- Published online on: September 11, 2020 https://doi.org/10.3892/etm.2020.9214
Copyright: © Bai
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
This study explored the diagnostic and therapeutic significance of vitamin D binding protein (VDBP) and miR‑155‑5p for diabetic nephropathy and the correlation with urinary microalbumin. A total of 145 patients with type 2 diabetes who attended the Hwamei hospital were selected as research objects and assigned to diabetic nephropathy group (DN group) and diabetes group according to whether they suffered from diabetic nephropathy (DN). The expression levels of urine VDBP and serum miR‑155‑5p in the two groups were detected, and the correlation between urinary microalbumin (mAlb), serum cystatin C (Cys C) and 24‑h urinary protein was analyzed. The predictive value of single and joint detection of urinary VDBP and serum miR‑155‑5p for DN onset and poor prognosis was analyzed. In DN patients, urine VDBP and serum miR‑155‑5p were highly expressed, and urine VDBP, serum miR‑155‑5p and mAlb, Cys C and 24‑h urine protein were positively correlated (P<0.05). Moreover, the joint detection of urine VDBP and serum miR‑155‑5p was more valuable in diagnosis and poor prognosis prediction of DN patients than its single detection. Urine VDBP and serum miR‑155‑5p have good diagnostic value for DN, but their joint diagnostic value is higher, and their expression levels are all related to mAlb of DN patients, which may be used as new biological indicators for diagnosis and disease assessment.