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Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin

  • Authors:
    • Xu Bai
    • Qun Luo
    • Kuibi Tan
    • Liming Guo
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315000, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 86
    |
    Published online on: September 11, 2020
       https://doi.org/10.3892/etm.2020.9214
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Abstract

This study explored the diagnostic and therapeutic significance of vitamin D binding protein (VDBP) and miR‑155‑5p for diabetic nephropathy and the correlation with urinary microalbumin. A total of 145 patients with type 2 diabetes who attended the Hwamei hospital were selected as research objects and assigned to diabetic nephropathy group (DN group) and diabetes group according to whether they suffered from diabetic nephropathy (DN). The expression levels of urine VDBP and serum miR‑155‑5p in the two groups were detected, and the correlation between urinary microalbumin (mAlb), serum cystatin C (Cys C) and 24‑h urinary protein was analyzed. The predictive value of single and joint detection of urinary VDBP and serum miR‑155‑5p for DN onset and poor prognosis was analyzed. In DN patients, urine VDBP and serum miR‑155‑5p were highly expressed, and urine VDBP, serum miR‑155‑5p and mAlb, Cys C and 24‑h urine protein were positively correlated (P<0.05). Moreover, the joint detection of urine VDBP and serum miR‑155‑5p was more valuable in diagnosis and poor prognosis prediction of DN patients than its single detection. Urine VDBP and serum miR‑155‑5p have good diagnostic value for DN, but their joint diagnostic value is higher, and their expression levels are all related to mAlb of DN patients, which may be used as new biological indicators for diagnosis and disease assessment.
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1 

Zhuang L, Jin G, Hu X, Yang Q and Shi Z: The inhibition of SGK1 suppresses epithelial-mesenchymal transition and promotes renal tubular epithelial cell autophagy in diabetic nephropathy. Am J Transl Res. 11:4946–4956. 2019.PubMed/NCBI

2 

Coskun ZM, Ersoz M, Adas M, Hancer VS, Boysan SN, Gonen MS and Acar A: Kruppel-like transcription factor-4 gene expression and DNA methylation status in type 2 diabetes and diabetic nephropathy patients. Arch Med Res. 50:91–97. 2019.PubMed/NCBI View Article : Google Scholar

3 

Jiang S, Yu T, Zhang Z, Fang J, Wang Y, Yang Y, Liu L, Zou G, Gao H, Zhuo L, et al: Prognostic nomogram and score to predict renal survival of patients with biopsy-proven diabetic nephropathy. Diabetes Res Clin Pract. 155(107809)2019.PubMed/NCBI View Article : Google Scholar

4 

Grujicic M, Salapura A, Basta-Jovanovic G, Figurek A, Micic-Zrnic D and Grbic A: Non-diabetic kidney disease in patients with type 2 diabetes mellitus - 11-year experience from a single center. Med Arh. 73:87–91. 2019.PubMed/NCBI View Article : Google Scholar

5 

Fawzy MS and Beladi FI: Association of circulating vitamin D, VDBP, and vitamin D receptor expression with severity of diabetic nephropathy in a group of Saudi type 2 diabetes mellitus patients. Clin Lab. 64:1623–1633. 2018.PubMed/NCBI View Article : Google Scholar

6 

Mirković K, Doorenbos CR, Dam WA, Lambers Heerspink HJ, Slagman MC, Nauta FL, Kramer AB, Gansevoort RT, van den Born J, Navis G, et al: Urinary vitamin D binding protein: A potential novel marker of renal interstitial inflammation and fibrosis. PLoS One. 8(e55887)2013.PubMed/NCBI View Article : Google Scholar

7 

Gu J, Huang W, Zhang W, Zhao T, Gao C, Gan W, Rao M, Chen Q, Guo M, Xu Y, et al: Sodium butyrate alleviates high-glucose -induced renal glomerular endothelial cells damage via inhibiting pyroptosis. Int Immunopharmacol. 75(105832)2019.PubMed/NCBI View Article : Google Scholar

8 

Ebadi Z, Moradi N, Kazemi Fard T, Balochnejadmojarrad T, Chamani E, Fadaei R and Fallah S: Captopril and spironolactone can attenuate diabetic nephropathy in Wistar rats by targeting microRNA-192 and microRNA-29a/b/c. DNA Cell Biol. 38:1134–1142. 2019.PubMed/NCBI View Article : Google Scholar

9 

Shi Q, Zhang Y, Liu W, Xiao H, Qi Y, Li J and Luo B: Latent membrane protein 2A inhibits expression level of Smad2 through regulating miR-155-5p in EBV-associated gastric cancer cell lines. J Med Virol. 92:96–106. 2020.PubMed/NCBI View Article : Google Scholar

10 

Wang J, Wang G, Liang Y and Zhou X: Expression profiling and clinical significance of plasma microRNAs in diabetic nephropathy. J Diabetes Res. 2019(5204394)2019.PubMed/NCBI View Article : Google Scholar

11 

Xie J, Wang X, Zhang Y, Li H, Xu Y and Zheng D: The longitudinal effect of subclinical hypothyroidism on urine microalbumin-to-urine creatinine ratio in patients with type 2 diabetes mellitus. BMC Endocr Disord. 19(84)2019.PubMed/NCBI View Article : Google Scholar

12 

Krueger DA, Northrup H, Northrup H, Krueger DA, Roberds S, Smith K, Sampson J, Korf B, Kwiatkowski DJ, Mowat D, et al: International Tuberous Sclerosis Complex Consensus Group: Tuberous sclerosis complex surveillance and management: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol. 49:255–265. 2013.PubMed/NCBI View Article : Google Scholar

13 

Kocak MZ, Aktas G, Erkus E, Duman TT, Atak BM and Savli H: Mean platelet volume to lymphocyte ratio as a novel marker for diabetic nephropathy. J Coll Physicians Surg Pak. 28:844–847. 2018.PubMed/NCBI View Article : Google Scholar

14 

Prabu P, Rome S, Sathishkumar C, Gastebois C, Meugnier E, Mohan V and Balasubramanyam M: MicroRNAs from urinary extracellular vesicles are non-invasive early biomarkers of diabetic nephropathy in type 2 diabetes patients with the ‘Asian Indian phenotype’. Diabetes Metab. 45:276–285. 2019.PubMed/NCBI View Article : Google Scholar

15 

Fawzy MS and Abu AlSel BT: Assessment of vitamin D-binding protein and early prediction of nephropathy in type 2 Saudi diabetic patients. J Diabetes Res. 2018(8517929)2018.PubMed/NCBI View Article : Google Scholar

16 

Shoukry A, Bdeer S-A and El-Sokkary RH: Urinary monocyte chemoattractant protein-1 and vitamin D-binding protein as biomarkers for early detection of diabetic nephropathy in type 2 diabetes mellitus. Mol Cell Biochem. 408:25–35. 2015.PubMed/NCBI View Article : Google Scholar

17 

Tian XQ, Zhao LM, Ge JP, Zhang Y and Xu YC: Elevated urinary level of vitamin D-binding protein as a novel biomarker for diabetic nephropathy. Exp Ther Med. 7:411–416. 2014.PubMed/NCBI View Article : Google Scholar

18 

Akhbari M, Khalili M, Shahrabi-Farahani M, Biglari A and Bandarian F: Expression level of circulating cell free miR-155 gene in serum of patients with diabetic nephropathy. Clin Lab. 65(65)2019.PubMed/NCBI View Article : Google Scholar

19 

Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J and Yu Z: Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies. Exp Clin Endocrinol Diabetes. 123:360–367. 2015.PubMed/NCBI View Article : Google Scholar

20 

Siddiqi Z, Karoli R, Kaul A, Fatima J, Varshney S and Beg MS: Evaluation of neutrophil gelatinase-associated lipocalin and cystatin C as early markers of diabetic nephropathy. Ann Afr Med. 16:101–106. 2017.PubMed/NCBI View Article : Google Scholar

21 

Liu R, Zhu H, Yang JH, Gao ZA, Yuan XX, Li XC, Wang JY and Chang BC: Can urine albumin/creatinine ratio replace 24 hs urinary albumin? Zhonghua Nei Ke Za Zhi. 58:377–381. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).

22 

Huang Y, Liu Y, Li L, Su B, Yang L, Fan W, Yin Q, Chen L, Cui T, Zhang J, et al: Involvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: Implications for glomerular endothelial injury. BMC Nephrol. 15(142)2014.PubMed/NCBI View Article : Google Scholar

23 

Wang G, Ouyang J, Li S, Wang H, Lian B, Liu Z and Xie L: The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases. J Transl Med. 17(264)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Bai X, Luo Q, Tan K and Guo L: Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin. Exp Ther Med 20: 86, 2020.
APA
Bai, X., Luo, Q., Tan, K., & Guo, L. (2020). Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin. Experimental and Therapeutic Medicine, 20, 86. https://doi.org/10.3892/etm.2020.9214
MLA
Bai, X., Luo, Q., Tan, K., Guo, L."Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin". Experimental and Therapeutic Medicine 20.5 (2020): 86.
Chicago
Bai, X., Luo, Q., Tan, K., Guo, L."Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin". Experimental and Therapeutic Medicine 20, no. 5 (2020): 86. https://doi.org/10.3892/etm.2020.9214
Copy and paste a formatted citation
x
Spandidos Publications style
Bai X, Luo Q, Tan K and Guo L: Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin. Exp Ther Med 20: 86, 2020.
APA
Bai, X., Luo, Q., Tan, K., & Guo, L. (2020). Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin. Experimental and Therapeutic Medicine, 20, 86. https://doi.org/10.3892/etm.2020.9214
MLA
Bai, X., Luo, Q., Tan, K., Guo, L."Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin". Experimental and Therapeutic Medicine 20.5 (2020): 86.
Chicago
Bai, X., Luo, Q., Tan, K., Guo, L."Diagnostic value of VDBP and miR‑155‑5p in diabetic nephropathy and the correlation with urinary microalbumin". Experimental and Therapeutic Medicine 20, no. 5 (2020): 86. https://doi.org/10.3892/etm.2020.9214
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