Roles of klotho and stem cells in mediating vascular calcification (Review)

  • Authors:
    • Liangzhu Yu
    • Mincai Li
  • View Affiliations

  • Published online on: September 24, 2020     https://doi.org/10.3892/etm.2020.9252
  • Article Number: 124
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Abstract

Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti‑aging protein klotho may act as an inhibitor of vascular calcification through direct effects on vascular stem/progenitor cells with osteogenic differentiation potential. A better understanding of the possible effects of klotho on vascular stem/progenitor cells may provide novel insight into the cellular and molecular mechanisms of klotho deficiency‑related vascular calcification and disease. The klotho protein may be considered as a promising therapeutic agent for treating vascular calcification and disease and calcification‑related vascular diseases.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yu L and Yu L: Roles of klotho and stem cells in mediating vascular calcification (Review). Exp Ther Med 20: 124, 2020
APA
Yu, L., & Yu, L. (2020). Roles of klotho and stem cells in mediating vascular calcification (Review). Experimental and Therapeutic Medicine, 20, 124. https://doi.org/10.3892/etm.2020.9252
MLA
Yu, L., Li, M."Roles of klotho and stem cells in mediating vascular calcification (Review)". Experimental and Therapeutic Medicine 20.6 (2020): 124.
Chicago
Yu, L., Li, M."Roles of klotho and stem cells in mediating vascular calcification (Review)". Experimental and Therapeutic Medicine 20, no. 6 (2020): 124. https://doi.org/10.3892/etm.2020.9252